Results 21 to 30 of about 2,385,812 (262)

Alterations of the human gut microbiome in multiple sclerosis

Nature Communications, 2016
The gut microbiome has been implicated in several autoimmune disorders. Here, the authors study the gut microbiome of patients with multiple sclerosis, and find correlations between altered abundance of certain gut microorganisms and changes in ...
Sushrut Jangi, Roopali Gandhi, Laura M. Cox, Ning Li, Felipe von Glehn, Raymond Yan, Bonny Patel, Maria Antonietta Mazzola, Shirong Liu, Bonnie L. Glanz, Sandra Cook, Stephanie Tankou, Fiona Stuart, Kirsy Melo, Parham Nejad, Kathleen Smith, Begüm D. Topçuolu, James Holden, Pia Kivisäkk, Tanuja Chitnis, Philip L. De Jager, Francisco J. Quintana, Georg K. Gerber, Lynn Bry, Howard L. Weiner   +24 more
doaj   +1 more source

Immunologic Basis of Vaccine Vectors [PDF]

, 2010
Efforts to make vaccines against infectious diseases as well as immunotherapies for cancer, autoimmune diseases and allergy have utilized a variety of heterologous expression systems, including viral and bacterial vectors, as well as DNA and RNA ...
Liu, Margaret A., Margaret A. Liu
core   +1 more source

Peripheral B-Cell Immunophenotyping Identifies Heterogeneity in IgG4-Related Disease

Frontiers in Immunology, 2021
ObjectivesTo elucidate heterogeneity of IgG4-related disease (IgG4-RD) based on B cell immunophenotyping.MethodsImmunophenotyping of 4 B-cell subsets in peripheral blood from patients with active IgG4-RD (aIgG4-RD, n=105) was performed using flow ...
Jieqiong Li, Zheng Liu, Panpan Zhang, Wei Lin, Hui Lu, Yu Peng, Linyi Peng, Jiaxin Zhou, Mu Wang, Hua Chen, Lidan Zhao, Li Wang, Chenman Qin, Chaojun Hu, Xiaofeng Zeng, Yan Zhao, Yunyun Fei, Wen Zhang   +17 more
doaj   +1 more source

Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis

Nature Communications, 2017
CD4+ T cells secreting interleukin-17 (TH17) have diverse functions in modulating autoimmune diseases. Here the authors show via transcriptome analyses that a subset of human TH 17 co-expressing interferon-γ (TH1/17) has a molecular signature similar to “
Dan Hu, Samuele Notarbartolo, Tom Croonenborghs, Bonny Patel, Ron Cialic, Tun-Hsiang Yang, Dominik Aschenbrenner, Karin M. Andersson, Marco Gattorno, Minh Pham, Pia Kivisakk, Isabelle V. Pierre, Youjin Lee, Karun Kiani, Maria Bokarewa, Emily Tjon, Nathalie Pochet, Federica Sallusto, Vijay K. Kuchroo, Howard L. Weiner   +19 more
doaj   +1 more source

Rare diseases and orphan drugs: Latvian story [PDF]

, 2014
Publisher Copyright: © 2014 Logviss et al.; licensee BioMed Central Ltd.Background: Ten years have passed since Latvia became a Member State of the EU in 2004.
Logviss, Konstantins, Krievins, Dainis, Purvina, Santa   +2 more
core   +1 more source

Utilization of Flow Cytometry in Immunologic and Allergic Diseases

, 2016
Flow cytometry is a device that analyzes the physical and/or chemical characteristics of cells or particles as they pass through a fluid system one by one.
Özdemir, Öner, Cagla Karavalzoglu, Karavaizoğlu, Çağla   +2 more
core   +1 more source

Cell therapy in Sjögren's syndrome: opportunities and challenges

Expert Reviews in Molecular Medicine
Sjögren's syndrome (SS) is a chronic autoimmune disease caused by immune system disorders. The main clinical manifestations of SS are dry mouth and eyes caused by the destruction of exocrine glands, such as the salivary and lacrimal glands, and systemic ...
Yangyang Lu, Rongjing Shi, Wenqin He, Qi An, Jingwen Zhao, Xinnan Gao, Baiyan Zhang, Liyun Zhang, Ke Xu, Dan Ma   +9 more
doaj   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MK2 Inhibitor ATI-450 in Healthy Subjects: A Placebo-Controlled, Randomized Phase 1 Study

Clinical Pharmacology: Advances and Applications, 2021
David Gordon,1 Edward T Hellriegel,1 Heidi Rath Hope,2 David Burt,1 Joseph B Monahan2 1Research and Development, Aclaris Therapeutics, Inc., Wayne, PA, USA; 2Research and Development, Aclaris Therapeutics, Inc., and Confluence Discovery Technologies, Inc.
Gordon D, Hellriegel ET, Hope HR, Burt D, Monahan JB   +4 more
doaj  

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Immunologic Mechanisms Involved in Viral Ocular Diseases

, 1980
Immunologic responses of the host play a key role in the intensity, duration, and subsequent damage associated with viral ocular diseases. Broadly speaking, the host responds to a particular viral infection by producing antibodies (humoral immunity) and ...
Chandler, John W.
core   +1 more source