Results 61 to 70 of about 9,537,711 (374)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Regulation of splenic monocyte homeostasis and function by gut microbial products

iScience, 2021
Summary: Splenic Ly6Chigh monocytes are innate immune cells involved in the regulation of central nervous system-related diseases. Recent studies have reported the shaping of peripheral immune responses by the gut microbiome via mostly unexplored ...
Panayota Kolypetri, Shirong Liu, Laura M. Cox, Mai Fujiwara, Radhika Raheja, Dvora Ghitza, Anya Song, Dominique Daatselaar, Valerie Willocq, Howard L. Weiner   +9 more
doaj  

11. Allergic and immunologic diseases of the skin.

Journal of Allergy and Clinical Immunology, 2003
Many skin diseases have an inflammatory or immune component, and anti-inflammatory drugs comprise a major portion of a dermatologist's therapeutic armamentarium. Although causes of most of these diseases remain obscure, mechanisms of lesion formation and
A. Blauvelt, S. Hwang, M. Udey
semanticscholar   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation

Cell Reports, 2020
Summary: Tim-1, a phosphatidylserine receptor expressed on B cells, induces interleukin 10 (IL-10) production by sensing apoptotic cells. Here we show that mice with B cell-specific Tim-1 deletion develop tissue inflammation in multiple organs including ...
Sheng Xiao, Lloyd Bod, Nathalie Pochet, Savithri Balasubramanian Kota, Dan Hu, Asaf Madi, Jessica Kilpatrick, Jingwen Shi, Allen Ho, Huiyuan Zhang, Raymond Sobel, Howard L. Weiner, Terry B. Strom, Francisco J. Quintana, Nicole Joller, Vijay K. Kuchroo   +15 more
doaj  

Immunological benefits by ginseng through reciprocal regulation of Th17 and Treg cells during cyclosporine-induced immunosuppression

Journal of Ginseng Research, 2016
Background: It is not clear whether ginseng affects cyclosporine A (CsA)-induced desirable immunosuppressive action. In this study, we evaluated the immunological influence of combined treatment of ginseng with CsA. Methods: Using CD4+ T cells from mouse
Seong Beom Heo, Sun Woo Lim, Joo Yeon Jhun, Mi La Cho, Byung Ha Chung, Chul Woo Yang   +5 more
doaj   +1 more source

THE EFFECT OF INDUCED CHRONIC VIRAL INFECTIONS ON THE IMMUNOLOGIC DISEASES OF NEW ZEALAND MICE

Journal of Experimental Medicine, 1970
Chronic infections induced at birth with either LCM, an RNA virus, or polyoma, a DNA virus, in NZB, NZW, and NZB x W mice enhance ANA formation, aggravate the immune complex glomerulonephritis, and increase the associated mortality.
G. Tonietti, M. Oldstone, F. Dixon
semanticscholar   +1 more source

Celiac Disease: An Immunological Jigsaw [PDF]

Immunity, 2012
Celiac disease (CD) is a chronic enteropathy induced by dietary gluten in genetically predisposed people. The keystone of CD pathogenesis is an adaptive immune response orchestrated by the interplay between gluten and MHC class II HLA-DQ2 and DQ8 molecules.
Nadine Cerf-Bensussan, Nadine Cerf-Bensussan, Georgia Malamut, Georgia Malamut, Bertrand Meresse, Bertrand Meresse   +5 more
openaire   +3 more sources

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Protein profiling in systemic sclerosis patients with different pulmonary complications using proteomic antibody microarray

Arthritis Research & Therapy
Background Pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) are leading causes of systemic sclerosis (SSc)-related death. In this study, we aimed to identify biomarkers for detecting SSc pulmonary complications that are mild and ...
Jing Huang, Honglin Zhu, Sijia Liu, Mengtao Li, Yisha Li, Hui Luo, Xiaoxia Zuo   +6 more
doaj   +1 more source