Results 71 to 80 of about 304,177 (292)

Benefit of viral load testing for confirmation of immunological failure in HIV patients treated in rural Malawi. [PDF]

, 2011
Objective  Viral load testing is used in the HIV programme of Chiradzulu, Malawi, to confirm the diagnosis of immunological failure to prevent unnecessary switching to second-line therapy.
Badri, Bisson, Calmy, Ekouevi, Ferradini, Kantor, Keiser, Lebon, Mee, Moore, Murri, Reynolds, van Oosterhout, World Health Organization, World Health Organization   +14 more
core   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Nod2 Deficiency in mice is Associated with Microbiota Variation Favouring the Expansion of mucosal CD4+ LAP+ Regulatory Cells [PDF]

, 2018
Nucleotide-binding Oligomerization Domain-2 (NOD2) mutations are associated with an increased risk to develop Crohn's Disease. In previous studies, we have shown that Nod2-/- mice manifest increased proportion of Lamina Propria (LP) CD4+ LAP+ Foxp3 ...
Boirivant, M., Boirivant, M., Butera, A., Cavalieri, D., De Filippo, C., Di Paola, M., Pavarini, L., Pindo, M., Sanchez, M., Strati, F.   +9 more
core   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Vitamin D supplementation in the pediatric rheumatology clinic. [PDF]

, 2011
Vitamin D is capturing the attention of healthy and chronically ill populations for its potential skeletal and nonskeletal benefits. New information suggesting a role in immune modulation has led to a surge of interest among rheumatologists. Although the
Burnham, Jon M, von Scheven, Emily
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Immunovirological outcomes and resistance patterns at 4 years of antiretroviral therapy use in HIV-infected patients in Cambodia [PDF]

, 2011
Objectives  To report immunovirological outcomes and resistance patterns in adults treated with triple combination antiretroviral therapy (cART) for 4 years in an HIV programme of Phnom Penh, Cambodia.
Balkan, Suna, Chanchhaya, Ngeth, Ferradini, Laurent, Narom, Prak, Nerrienet, Eric, Pujades-Rodríguez, Mar, Schramm, Birgit, Som, Leakena   +7 more
core   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Assessment of the effect of a protein calorie supplement on change in CD4 count among art-naïve female TB patients co-infected with HIV in Dar Es Salaam, Tanzania [PDF]

, 2017
RATIONALE: Tuberculosis and HIV infection together form a highly mortal combination. Even after the advent of highly active antiretroviral therapy (HAART) medications, management for Tuberculosis and HIV/AIDS still remains a challenge. Poor outcomes (in
Magohe, Albert Katana
core   +1 more source

Distinguishing Asthma Phenotypes Using Machine Learning Approaches. [PDF]

, 2015
Asthma is not a single disease, but an umbrella term for a number of distinct diseases, each of which are caused by a distinct underlying pathophysiological mechanism. These discrete disease entities are often labelled as asthma endotypes.
A Custovic, A Custovic, A Fraser, A Høst, A Pickles, A Simpson, A Wijga, Adnan Custovic, AJ Lowe, AV Berg, B Clarisse, BD Spycher, BD Spycher, BD Spycher, BG Toelle, BL Jones, BL Jones, C-M Chen, CA Figueiredo, CE Kuehni, CJ Lodge, CL Storr, D Barber, D Belgrave, D Caudri, D Nagin, DA Linzer, DC Belgrave, DC Belgrave, DCM Belgrave, DCM Belgrave, F Kauffmann, F Kauffmann, FD Martinez, FL Garden, FP Perera, G Bochenek, G Weinmayr, GB Marks, GP Anderson, J Hagenaars, J Henderson, J Lotvall, J Magidson, J Sunyer, J Winn, JA Smith, JK Vermunt, K Burnham, KE Wonderen Van, KL Nylund, L García-Marcos Álvarez, L Hunt, L Lowe, L Panico, LA Lowe, M Depner, M Herr, M Scott, Magnus Rattray, Mattia Prosperi, MJ Ege, ML Barreto, MM Hagendorens, MW Pijnenburg, N Lazic, NC Nicolaou, NG Papadopoulos, OE Savenije, P Burney, P Haldar, P Rzehak, P Rzehak, PD Sly, Q Chen, Q Vuong, Rebecca Howard, RJP Valk van der, RL Bergmann, RL Miller, RO Crapo, RT Stein, S American Thoracic, S Havstad, S Mihrshahi, S Rabe-Hesketh, S Stanojevic, SE Wenzel, SK Weiland, ST Lanza, ST Lanza, T Jung, T Minka, The European Community Respiratory Health Survey, V Siroux, WC Moore, X Robin, Y Lo   +97 more
core   +2 more sources