Results 41 to 50 of about 1,924,532 (299)

Memory Tracks [PDF]

, 2018
Memory Tracks is a care platform that uses music as reminiscence songs to support those living with cognitive impairment or with issues of well-being.
Brill, Mark
core   +6 more sources

Tuberculosis preventive therapy in postpartum women with HIV modifies M. tuberculosis-specific and nonspecific immune responses

Frontiers in Immunology
BackgroundTuberculosis (TB) has significant morbidity in pregnant and postpartum women with HIV (pregnant and PPWWHIV). TB preventive therapy (TPT) is recommended in pregnant and PPWWHIV with documented or presumed latent TB infection (LTBI).
Damayanti Yengkhom, Grace Montepiedra, Gaerolwe Masheto, Deo Wabwire, Lynda Stranix-Chibanda, Allen Matubu, Avy Violari, Gerhard Theron, Amita Gupta, Adriana Weinberg, Adriana Weinberg   +10 more
doaj   +1 more source

A delayed fractionated dose RTS,S AS01 vaccine regimen mediates protection via improved T follicular helper and B cell responses

eLife, 2020
Malaria-071, a controlled human malaria infection trial, demonstrated that administration of three doses of RTS,S/AS01 malaria vaccine given at one-month intervals was inferior to a delayed fractional dose (DFD) schedule (62.5% vs 86.7% protection ...
Suresh Pallikkuth, Sidhartha Chaudhury, Pinyi Lu, Li Pan, Erik Jongert, Ulrike Wille-Reece, Savita Pahwa   +6 more
doaj   +1 more source

Cellular size as a means of tracking mTOR activity and cell fate of CD4+ T cells upon antigen recognition. [PDF]

PLoS ONE, 2015
mTOR is a central integrator of metabolic and immunological stimuli, dictating immune cell activation, proliferation and differentiation. In this study, we demonstrate that within a clonal population of activated T cells, there exist both mTORhi and ...
Kristen N Pollizzi, Adam T Waickman, Chirag H Patel, Im Hong Sun, Jonathan D Powell   +4 more
doaj   +1 more source

On immunological memory

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2000
Immunological memory may not represent a special characteristic of lymphocytes but simply reflect lowlevel responses driven by antigen that is re–encountered or persists within the host. T–cell memory is important to control persistent infections within the individual host and cannot be transmitted to offspring because of MHC polymorphism and MHC ...
openaire   +4 more sources

STING agonism enhances anti-tumor immune responses and therapeutic efficacy of PARP inhibition in BRCA-associated breast cancer

npj Breast Cancer, 2022
Poly (ADP-ribose) polymerase (PARP) inhibitors exert their efficacy via synthetic lethal effects and by inducing cGAS/STING-mediated immune responses. We demonstrate that compared to monotherapies, combined PARP inhibition and STING agonism results in ...
Constantia Pantelidou, Heta Jadhav, Aditi Kothari, Renyan Liu, Gerburg M. Wulf, Jennifer L. Guerriero, Geoffrey I. Shapiro   +6 more
doaj   +1 more source

Persistence of anti-HBs and immunologic memory in children immunized with hepatitis B vaccine

Bangabandhu Sheikh Mujib Medical University Journal, 2023
Background:  We aimed to examine the persistence of anti-HBs in Bangladeshi children aged 5 and 10 years after primary vaccination, and this response to a booster dose. Methods: A total of 100 children were enrolled who were divided into two groups (A
Sharif Md Habibur Rahman, Md Rukunuzzaman, Rubaiyat Alam, Khan Lamia Nahid   +3 more
doaj   +1 more source

Demonstration of immunologic memory using serogroup C meningococcal glycoconjugate vaccine.

, 2009
BACKGROUND: Studies of glycoconjugate vaccines have traditionally used an immune challenge with a plain polysaccharide vaccine to demonstrate immunologic memory.
Maclennan, JM, Lockhart, S, Yu, LM, Snape, MD, English, M, English, Mike, Pollard, AJ, Pollard, Andrew, Moxon, RE   +8 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source