Results 31 to 40 of about 43,875 (259)

The presence of anti-nuclear antibodies alone is associated with changes in B cell activation and T follicular helper cells similar to those in systemic autoimmune rheumatic disease

Arthritis Research & Therapy, 2018
Background Diagnosis of systemic autoimmune rheumatic diseases (SARD) relies on the presence of hallmark anti-nuclear antibodies (ANA), many of which can be detected years before clinical manifestations. However, ANAs are also seen in healthy individuals,
Yuriy Baglaenko, Nan-Hua Chang, Sindhu R. Johnson, Waleed Hafiz, Kieran Manion, Dario Ferri, Babak Noamani, Dennisse Bonilla, Sina Rusta-Sellehy, Larissa Lisnevskaia, Earl Silverman, Arthur Bookman, Carolina Landolt-Marticorena, Joan Wither   +13 more
doaj   +1 more source

Cellular size as a means of tracking mTOR activity and cell fate of CD4+ T cells upon antigen recognition. [PDF]

PLoS ONE, 2015
mTOR is a central integrator of metabolic and immunological stimuli, dictating immune cell activation, proliferation and differentiation. In this study, we demonstrate that within a clonal population of activated T cells, there exist both mTORhi and ...
Kristen N Pollizzi, Adam T Waickman, Chirag H Patel, Im Hong Sun, Jonathan D Powell   +4 more
doaj   +1 more source

Immunological Memory of Psoriatic Lesions [PDF]

International Journal of Molecular Sciences, 2020
The natural course of psoriasis is the appearance of new lesions in the place of previous ones, which disappeared after a successful therapy. Recent studies of psoriasis etiopathogenesis showed that after psoriatic plaques have disappeared, in healthy skin we can still find a trace of inflammation in the form of tissue resident memory cells (TRM). They
Agnieszka Owczarczyk-Saczonek, Magdalena Krajewska-Włodarczyk, Marta Kasprowicz-Furmańczyk, Waldemar Placek   +3 more
openaire   +2 more sources

A delayed fractionated dose RTS,S AS01 vaccine regimen mediates protection via improved T follicular helper and B cell responses

eLife, 2020
Malaria-071, a controlled human malaria infection trial, demonstrated that administration of three doses of RTS,S/AS01 malaria vaccine given at one-month intervals was inferior to a delayed fractional dose (DFD) schedule (62.5% vs 86.7% protection ...
Suresh Pallikkuth, Sidhartha Chaudhury, Pinyi Lu, Li Pan, Erik Jongert, Ulrike Wille-Reece, Savita Pahwa   +6 more
doaj   +1 more source

Persistence of anti-HBs and immunologic memory in children immunized with hepatitis B vaccine

Bangabandhu Sheikh Mujib Medical University Journal, 2023
Background:  We aimed to examine the persistence of anti-HBs in Bangladeshi children aged 5 and 10 years after primary vaccination, and this response to a booster dose. Methods: A total of 100 children were enrolled who were divided into two groups (A
Sharif Md Habibur Rahman, Md Rukunuzzaman, Rubaiyat Alam, Khan Lamia Nahid   +3 more
doaj   +1 more source

STING agonism enhances anti-tumor immune responses and therapeutic efficacy of PARP inhibition in BRCA-associated breast cancer

npj Breast Cancer, 2022
Poly (ADP-ribose) polymerase (PARP) inhibitors exert their efficacy via synthetic lethal effects and by inducing cGAS/STING-mediated immune responses. We demonstrate that compared to monotherapies, combined PARP inhibition and STING agonism results in ...
Constantia Pantelidou, Heta Jadhav, Aditi Kothari, Renyan Liu, Gerburg M. Wulf, Jennifer L. Guerriero, Geoffrey I. Shapiro   +6 more
doaj   +1 more source

High MMP-11 expression associated with low CD8+ T cells decreases the survival rate in patients with breast cancer.

PLoS ONE, 2021
Matrix metalloproteinase-11 (MMP-11) promote cancer invasion and metastasis through degrading the extracellular matrix. Protein degradation by MMP-11 in tumor cells may progressively suppress cancer surveillance activities with blocking immune response ...
Hyung Suk Kim, Min Gyu Kim, Kyueng-Whan Min, Un Suk Jung, Dong-Hoon Kim   +4 more
doaj   +1 more source

On immunological memory

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2000
Immunological memory may not represent a special characteristic of lymphocytes but simply reflect lowlevel responses driven by antigen that is re–encountered or persists within the host. T–cell memory is important to control persistent infections within the individual host and cannot be transmitted to offspring because of MHC polymorphism and MHC ...
openaire   +4 more sources

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Immune microenvironment modulation unmasks therapeutic benefit of radiotherapy and checkpoint inhibition

Journal for ImmunoTherapy of Cancer, 2019
Background Immune checkpoint inhibitors (ICIs) for solid tumors, including those targeting programmed cell death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), have shown impressive clinical efficacy, however, most patients do not ...
Jared M. Newton, Aurelie Hanoteau, Hsuan-Chen Liu, Angelina Gaspero, Falguni Parikh, Robyn D. Gartrell-Corrado, Thomas D. Hart, Damya Laoui, Jo A. Van Ginderachter, Neeraja Dharmaraj, William C. Spanos, Yvonne Saenger, Simon Young, Andrew G. Sikora   +13 more
doaj   +1 more source