Results 51 to 60 of about 75,193 (298)
Allergy, Asthma & Clinical Immunology, 2022 Background Prolidase deficiency (PD) is an autosomal recessive inborn multisystemic disease caused by mutations in the PEPD gene encoding the enzyme prolidase D, leading to defects in turnover of proline-containing proteins, such as collagen.
Nora Alrumayyan +7 more
doaj +1 more source
216 Jewish Hospital of St. Louis [PDF]
, 1965 https://digitalcommons.wustl.edu/bjc_216/1066/thumbnail ...
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2000 Immunological memory may not represent a special characteristic of lymphocytes but simply reflect lowlevel responses driven by antigen that is re–encountered or persists within the host. T–cell memory is important to control persistent infections within the individual host and cannot be transmitted to offspring because of MHC polymorphism and MHC ...
openaire +3 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Frontiers in Neurology, 2021 Purpose: Previous studies have shown that HIV affects striato-cortical regions, leading to persisting cognitive impairment in 30–70% of the infected individuals despite combination antiretroviral therapy.
Benedictor Alexander Nguchu +10 more
doaj +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
PROBLEMS OF VACCINAL PREVENTION OF DEEP MYCOSES
Эпидемиология и вакцинопрофилактика, 2016 A literature review presents date obtained during the last years about the strategy of production and protective characteristics of different experimental vaccines against opportunistic and particularly dangerous deep mycoses.
A. V. Lipnitsky +2 more
doaj +1 more source
IMMUNOLOGICAL MEMORY IN VITRO [PDF]
The Journal of Experimental Medicine, 1971 The immune responses to sheep erythrocytes of mouse spleen cell suspensions from immune and nonimmune donors were compared in vitro. In vivo immunity was only transiently reflected in vitro, and 8 wk after in vivo immunization the responses of cultures from immunized and nonimmunized mice were virtually identical.
Radcliffe, G N, Axelrad, M A
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T-cell subpopulations αβ and γδ in cord blood of very preterm infants : The influence of intrauterine infection [PDF]
, 2013 Open Access: This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are creditedPreterm infants are very ...
A Kotiranta-Ainamo +36 more
core +1 more source