Altered actin centripetal retrograde flow in physically restricted immunological synapses. [PDF]
PLoS ONE, 2010 Antigen recognition by T cells involves large scale spatial reorganization of numerous receptor, adhesion, and costimulatory proteins within the T cell-antigen presenting cell (APC) junction.
Cheng-han Yu +4 more
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Comparative anatomy of phagocytic and immunological synapses [PDF]
Frontiers in Immunology, 2016 The generation of phagocytic cups and immunological synapses are crucial events of the innate and adaptive immune responses, respectively. They are triggered by distinct immune receptors and performed by different cell types.
Florence eNiedergang +2 more
doaj +6 more sources
Deep-learning-based three-dimensional label-free tracking and analysis of immunological synapses of CAR-T cells [PDF]
eLife, 2020 The immunological synapse (IS) is a cell-cell junction between a T cell and a professional antigen-presenting cell. Since the IS formation is a critical step for the initiation of an antigen-specific immune response, various live-cell imaging techniques,
Moosung Lee +7 more
doaj +2 more sources
Bispecific Antibody Format and the Organization of Immunological Synapses in T Cell-Redirecting Strategies for Cancer Immunotherapy [PDF]
Pharmaceutics, 2022 T cell-redirecting strategies have emerged as effective cancer immunotherapy approaches. Bispecific antibodies (bsAbs) are designed to specifically recruit T cells to the tumor microenvironment and induce the assembly of the immunological synapse (IS ...
Carlos Carrasco-Padilla +4 more
doaj +2 more sources
Immune mobilising T cell receptors redirect polyclonal CD8+ T cells in chronic HIV infection to form immunological synapses [PDF]
Scientific Reports, 2022 T cell exhaustion develops in human immunodeficiency virus (HIV) infection due to chronic viral antigenic stimulation. This adaptive response primarily affects virus-specific CD8+ T cells, which may remain dysfunctional despite viral load-reducing ...
Zoë Wallace +6 more
doaj +2 more sources
Transcriptional regulation of Tfh dynamics and the formation of immunological synapses [PDF]
Experimental and Molecular MedicineInside germinal centers (GCs), antigen-specific B cells rely on precise interactions with immune cells and strategic localization between the dark and light zones to clonally expand, undergo affinity maturation, and differentiate into long-lived plasma ...
Ye-Ji Kim, Jinyong Choi, Youn Soo Choi
doaj +2 more sources
Self-reactive human CD4 T cell clones form unusual immunological synapses. [PDF]
J Exp Med, 2012 Recognition of self–peptide-MHC (pMHC) complexes by CD4 T cells plays an important role in the pathogenesis of many autoimmune diseases. We analyzed formation of immunological synapses (IS) in self-reactive T cell clones from patients with multiple ...
Schubert DA +12 more
europepmc +3 more sources
Understanding the Spatial Topology of Artificial Immunological Synapses Assembled in T Cell-Redirecting Strategies: A Major Issue in Cancer Immunotherapy [PDF]
Frontiers in Cell and Developmental Biology, 2020 Pedro Roda-Navarro +3 more
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Geometrically repatterned immunological synapses uncover formation mechanisms. [PDF]
PLoS Computational Biology, 2006 The interaction of T cells and antigen-presenting cells is central to adaptive immunity and involves the formation of immunological synapses in many cases.
Marc Thilo Figge, Michael Meyer-Hermann
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The Nanoscopic Organization of Synapse Structures: A Common Basis for Cell Communication
Membranes, 2021 Synapse structures, including neuronal and immunological synapses, can be seen as the plasma membrane contact sites between two individual cells where information is transmitted from one cell to the other. The distance between the two plasma membranes is
Xiaojuan Yang, Wim Annaert
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