Comparative anatomy of phagocytic and immunological synapses [PDF]
Frontiers in Immunology, 2016 The generation of phagocytic cups and immunological synapses are crucial events of the innate and adaptive immune responses, respectively. They are triggered by distinct immune receptors and performed by different cell types.
Florence eNiedergang +2 more
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Bispecific Antibody Format and the Organization of Immunological Synapses in T Cell-Redirecting Strategies for Cancer Immunotherapy [PDF]
Pharmaceutics, 2022 T cell-redirecting strategies have emerged as effective cancer immunotherapy approaches. Bispecific antibodies (bsAbs) are designed to specifically recruit T cells to the tumor microenvironment and induce the assembly of the immunological synapse (IS ...
Carlos Carrasco-Padilla +4 more
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Deep-learning-based three-dimensional label-free tracking and analysis of immunological synapses of CAR-T cells [PDF]
eLife, 2020 The immunological synapse (IS) is a cell-cell junction between a T cell and a professional antigen-presenting cell. Since the IS formation is a critical step for the initiation of an antigen-specific immune response, various live-cell imaging techniques,
Moosung Lee +7 more
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Immune mobilising T cell receptors redirect polyclonal CD8+ T cells in chronic HIV infection to form immunological synapses [PDF]
Scientific Reports, 2022 T cell exhaustion develops in human immunodeficiency virus (HIV) infection due to chronic viral antigenic stimulation. This adaptive response primarily affects virus-specific CD8+ T cells, which may remain dysfunctional despite viral load-reducing ...
Zoë Wallace +6 more
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Transcriptional regulation of Tfh dynamics and the formation of immunological synapses [PDF]
Experimental and Molecular MedicineInside germinal centers (GCs), antigen-specific B cells rely on precise interactions with immune cells and strategic localization between the dark and light zones to clonally expand, undergo affinity maturation, and differentiate into long-lived plasma ...
Ye-Ji Kim, Jinyong Choi, Youn Soo Choi
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Altered actin centripetal retrograde flow in physically restricted immunological synapses. [PDF]
PLoS ONE, 2010 Antigen recognition by T cells involves large scale spatial reorganization of numerous receptor, adhesion, and costimulatory proteins within the T cell-antigen presenting cell (APC) junction.
Cheng-han Yu +4 more
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Understanding the Spatial Topology of Artificial Immunological Synapses Assembled in T Cell-Redirecting Strategies: A Major Issue in Cancer Immunotherapy [PDF]
Frontiers in Cell and Developmental Biology, 2020 Pedro Roda-Navarro +3 more
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Editorial: Structure and function of the immunological and redirecting artificial synapses and their clinical implications [PDF]
Frontiers in ImmunologyManuel Izquierdo +6 more
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T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: a novel astrocyte response mechanism to cellular injury. [PDF]
PLoS ONE, 2008 Astrocytes usually respond to trauma, stroke, or neurodegeneration by undergoing cellular hypertrophy, yet, their response to a specific immune attack by T cells is poorly understood.
Carlos Barcia +8 more
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Geometrically repatterned immunological synapses uncover formation mechanisms. [PDF]
PLoS Computational Biology, 2006 The interaction of T cells and antigen-presenting cells is central to adaptive immunity and involves the formation of immunological synapses in many cases.
Marc Thilo Figge, Michael Meyer-Hermann
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