Results 91 to 100 of about 462,461 (237)

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Testing the organization of the immunological synapse [PDF]

Current Opinion in Immunology, 2007
Upon encounter with antigen-bearing presenting cells, T cells initiate the formation of a unique junction termed the immunological synapse (IS). The morphology of this junction, characterized in EM as a series of discrete contacts into which are interspersed synaptic spaces [1], has multiple similarities to neuronal synapses.
openaire   +2 more sources

Imaging the microanatomy of astrocyte-T-cell interactions in immune-mediated inflammation

Frontiers in Cellular Neuroscience, 2013
The role of astrocytes in the immune-mediated inflammatory response in the brain is more prominent than previously thought. Astrocytes become reactive in response to neuro-inflammatory stimuli through multiple pathways, contributing significantly to the ...
Carlos eBarcia, Izaskun eMitxitorena, María Angeles Carrillo-de Sauvage, José María Gallego, Carlos eBarcia, Ana ePerez-Valles, Carlos eBarcia   +6 more
doaj   +1 more source

Spinophilin participates in information transfer at immunological synapses

Journal of Cell Biology, 2008
The adaptive immune response is initiated by the presentation of peptides bound to major histocompatibility complex molecules on dendritic cells (DCs) to antigen-specific T lymphocytes at a junction termed the immunological synapse.
O. Bloom, J. Unternaehrer, Aimin Jiang, Jeong-Sook Shin, L. Delamarre, P. Allen, I. Mellman   +6 more
semanticscholar   +1 more source

The use of deidentified organ donor testes for research

Andrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source

Supported Planar Bilayers for the Formation of Study of Immunological Synapses and Kinapse

Journal of Visualized Experiments, 2008
Supported planar bilayers are powerful tools that can be used to model the molecular interactions in an immunological synapse. To mimic the interactions between lymphocytes and antigen presenting cells, we use Ni2+-chelating lipids to anchor recombinant ...

semanticscholar   +1 more source

Herpes simplex virus‐1 infection alters microtubule‐associated protein Tau splicing and promotes Tau pathology in neural models of Alzheimer's disease

Brain Pathology, EarlyView.
HSV‐1 infection alters MAPT splicing and promotes Tau pathology in neural models of Alzheimer's disease. HSV‐1 infection in brain organoids and neuronal models increase 4R‐MAPT splicing and Tau hyperphosphorylation. HSV‐1 ICP27 is both necessary and sufficient for inducing these changes highlighting the potential role of HSV‐1 in Alzheimer's disease ...
Emmanuel C. Ijezie, Michael J. Miller, Celine Hardy, Ava R. Jarvis, Timothy F. Czajka, Lianna D'Brant, Natasha Rugenstein, Adam Waickman, Eain Murphy, David C. Butler   +9 more
wiley   +1 more source

The Immunological Synapse--a Multitasking System

Science, 2002
The immunological synapse, the interface between the T cell and antigen-presenting cell (APC), is thought to be important for enhancing and sustaining signaling by the T cell receptor after it has engaged antigenic peptide on the APC surface. In a Perspective, van der Merwe and Davis discuss new findings ( Lee et al.) demonstrating ...
Van Der Merwe, P, Davis, S
openaire   +3 more sources

A Biomimetic Approach for the Creation of Two-Dimensional Microscale Surface Patterns: Creation of Isolated Immunological Synapses

International Journal of Biomaterials, 2009
Current efforts in surface functionalization have not produced a robust technique capable of creating specific two-dimensional microscale geometrical arrays composed of multiple proteins.
Eric Stern, David J. Mooney, Tarek M. Fahmy   +2 more
doaj   +1 more source

Immunity and neuroinflammation in early stages of life and epilepsy

Epilepsia, EarlyView.
Abstract The immune system is crucial for the correct brain development, and recent findings also point toward central control of immune response. As the immune system is not fully developed at birth, the early years become an important window for infections and for the development of epilepsy.
Angelica Vega García, María Leonor López‐Meraz, Marco I. González, Luisa Rocha, Jose Eduardo Peixoto‐Santos, Esper Abrão Cavalheiro   +5 more
wiley   +1 more source