Results 91 to 100 of about 13,144 (238)
Imaging the microanatomy of astrocyte-T-cell interactions in immune-mediated inflammation
Frontiers in Cellular Neuroscience, 2013 The role of astrocytes in the immune-mediated inflammatory response in the brain is more prominent than previously thought. Astrocytes become reactive in response to neuro-inflammatory stimuli through multiple pathways, contributing significantly to the ...
Carlos eBarcia +6 more
doaj +1 more source
A statistical mechanics approach to autopoietic immune networks [PDF]
, 2010 The aim of this work is to try to bridge over theoretical immunology and disordered statistical mechanics. Our long term hope is to contribute to the development of a quantitative theoretical immunology from which practical applications may stem. In order to make theoretical immunology appealing to the statistical physicist audience we are going to ...
arxiv +1 more source
Opportunities to Modulate Tumor Ecosystem Toward Successful Glioblastoma Immunotherapy
Cancer Science, EarlyView.There remain outstanding gaps between the negative results from clinical trials and the actual potential of the immune system for glioblastoma. To bridge this crucial gap, we collaborated with Dr. Mariko Takahashi, an expert in immunobiology and drug development, and Dr. James J.
Mariko Takahashi +5 more
wiley +1 more source
Lipid switches in the immunological synapse
Journal of Biological ChemistryAdaptive immune responses comprise the activation of T cells by peptide antigens that are presented by proteins of the Major Histocompatibility Complex (MHC) on the surface of an antigen-presenting cell. As a consequence of the T cell receptor interacting productively with a certain peptide-MHC complex, a specialized cell-cell junction known as the ...
Griffiths, Gillian +2 more
openaire +2 more sources
Testing the organization of the immunological synapse [PDF]
Current Opinion in Immunology, 2007 Upon encounter with antigen-bearing presenting cells, T cells initiate the formation of a unique junction termed the immunological synapse (IS). The morphology of this junction, characterized in EM as a series of discrete contacts into which are interspersed synaptic spaces [1], has multiple similarities to neuronal synapses.
openaire +2 more sources
Understanding the Structure and Function of the Immunological Synapse [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 The immunological synapse has been an area of very active scientific interest over the last decade. Surprisingly, much about the synapse remains unknown or is controversial. Here we review some of these current issues in the field: how the synapse is defined, its potential role in T-cell function, and our current understanding about how the synapse is ...
Dustin, M, Chakraborty, A, Shaw, A
openaire +4 more sources
Interplay between membrane elasticity and active cytoskeleton forces regulates the aggregation dynamics of the immunological synapse [PDF]
Soft Matter 13, 6938 (2017), 2017 Adhesion between a T cell and an antigen presenting cell is achieved by TCR-pMHC and LFA1-ICAM1 protein complexes. These segregate to form a special pattern, known as the immunological synapse (IS), consisting of a central quasi-circular domain of TCR-pMHC bonds surrounded by a peripheral domain of LFA1-ICAM1 complexes.
arxiv
d‐amino acids: new functional insights
The FEBS Journal, EarlyView.This review explores recent advances in understanding d‐amino acids (d‐AAs) and their pivotal roles across organisms, from plants to humans. d‐AAs have been implicated in key physiological processes, including cancer, inflammation, immune regulation, kidney disease, diabetes, and nervous system function.
Loredano Pollegioni +5 more
wiley +1 more source
International Journal of Biomaterials, 2009 Current efforts in surface functionalization have not produced a robust technique capable of creating specific two-dimensional microscale geometrical arrays composed of multiple proteins.
Eric Stern +2 more
doaj +1 more source
Immunological recognition by artificial neural networks [PDF]
, 2018 The binding affinity between the T-cell receptors (TCRs) and antigenic peptides mainly determines immunological recognition. It is not a trivial task that T cells identify the digital sequences of peptide amino acids by simply relying on the integrated binding affinity between TCRs and antigenic peptides. To address this problem, we examine whether the
arxiv +1 more source