Results 101 to 110 of about 462,461 (237)

A dynamic view of the immunological synapse

Seminars in Immunology, 2005
T cell activation requires interactions of T cell antigen receptors (TCR) and peptides presented by major histocompatibility complex molecules (MHCp) in an adhesive junction between the T cell and antigen-presenting cell. Stable junctions with bull's eye supramolecular activation clusters (SMACs) have been defined as immunological synapses (IS).
openaire   +3 more sources

d‐amino acids: new functional insights

The FEBS Journal, EarlyView.
This review explores recent advances in understanding d‐amino acids (d‐AAs) and their pivotal roles across organisms, from plants to humans. d‐AAs have been implicated in key physiological processes, including cancer, inflammation, immune regulation, kidney disease, diabetes, and nervous system function.
Loredano Pollegioni, Natasa Kustrimovic, Luciano Piubelli, Elena Rosini, Valentina Rabattoni, Silvia Sacchi   +5 more
wiley   +1 more source

Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells

eLife, 2019
Planar supported lipid bilayers (PSLB) presenting T cell receptor (TCR) ligands and ICAM-1 induce budding of extracellular microvesicles enriched in functional TCR, defined here as synaptic ectosomes (SE), from helper T cells.
David G Saliba, Pablo F Céspedes-Donoso, Štefan Bálint, Ewoud B Compeer, Kseniya Korobchevskaya, Salvatore Valvo, Viveka Mayya, Audun Kvalvaag, Yanchun Peng, Tao Dong, Maria-Laura Tognoli, Eric O'Neill, Sarah Bonham, Roman Fischer, Benedikt M Kessler, Michael L Dustin   +15 more
doaj   +1 more source

The Landscape of SPP1+ Macrophages Across Tissues and Diseases: A Comprehensive Review

Immunology, EarlyView.
SPP1+ macrophages represent a conserved, disease‐associated population present across cancerous and non‐cancerous conditions, involved in immunosuppression, fibrosis, lipid metabolism, phagocytosis, and other cellular processes. This review highlights their shared molecular programmes across tissues, their interactions with stromal and immune cells ...
Alessandro Palma
wiley   +1 more source

Format and geometries matter: Structure-based design defines the functionality of bispecific antibodies

Computational and Structural Biotechnology Journal, 2020
Multispecific antibodies can be generated in different formats. More than two decades of R&D in the field of bispecific antibody engineering revealed that the design and choice of format can have a profound impact on the antibody functionality.
Steffen Dickopf, Guy J. Georges, Ulrich Brinkmann   +2 more
doaj  

Microclusters of inhibitory killer immunoglobulin–like receptor signaling at natural killer cell immunological synapses

Journal of Cell Biology, 2006
We report the supramolecular organization of killer Ig–like receptor (KIR) phosphorylation using a technique applicable to imaging phosphorylation of any green fluorescent protein–tagged receptor at an intercellular contact or immune synapse ...
B. Treanor, P. Lanigan, Sunil Kumar, C. Dunsby, I. Munro, E. Auksorius, F. Culley, M. Purbhoo, David Phillips, M. Neil, D. Burshtyn, P. French, D. Davis   +12 more
semanticscholar   +1 more source

The role of the oral microbiome, host response, and periodontal disease treatment in Alzheimer's disease: A primer

Periodontology 2000, EarlyView.
Abstract Background Alzheimer‘s disease (AD) is the leading cause of cognitive impairment and dementia in elderly patients worldwide. There is increasing evidence that periodontal disease may have an important role in the complex, multifactorial pathogenesis of AD. Aim This narrative review aims to (1) highlight the current understanding of the role of
Jaclyn C. Chalmers, Yvonne L. Hernandez‐Kapila   +1 more
wiley   +1 more source

Updated insights into the molecular pathogenesis of canine atopic dermatitis

Veterinary Dermatology, EarlyView.
Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley   +1 more source

Bridging metabolic syndrome and cognitive dysfunction: role of astrocytes

Frontiers in Endocrinology
Metabolic syndrome (MetS) and cognitive dysfunction pose significant challenges to global health and the economy. Systemic inflammation, endocrine disruption, and autoregulatory impairment drive neurodegeneration and microcirculatory damage in MetS.
Zihan Li, Zihan Li, Ya-yi Jiang, Ya-yi Jiang, Caiyi Long, Caiyi Long, Xi Peng, Xi Peng, Jiajing Tao, Jiajing Tao, Yueheng Pu, Yueheng Pu, Rensong Yue, Rensong Yue   +13 more
doaj   +1 more source

Presynaptic quantal size enhancement counteracts post‐tetanic release depression

The Journal of Physiology, EarlyView.
Abstract figure legend Sustained high‐frequency stimulation decreases the number of synaptic vesicles that fuse per action potential at the Drosophila neuromuscular junction. However, the postsynaptic response remains largely unchanged. An increased postsynaptic response to individual vesicles, likely driven by an increase in vesicle size resulting ...
Anu G. Nair, Nasrin Bollmohr, Levin Schökle, Jennifer Keim, José María Mateos Melero, Martin Müller   +5 more
wiley   +1 more source