Results 111 to 120 of about 13,144 (238)

Bridging metabolic syndrome and cognitive dysfunction: role of astrocytes

Frontiers in Endocrinology
Metabolic syndrome (MetS) and cognitive dysfunction pose significant challenges to global health and the economy. Systemic inflammation, endocrine disruption, and autoregulatory impairment drive neurodegeneration and microcirculatory damage in MetS.
Zihan Li, Zihan Li, Ya-yi Jiang, Ya-yi Jiang, Caiyi Long, Caiyi Long, Xi Peng, Xi Peng, Jiajing Tao, Jiajing Tao, Yueheng Pu, Yueheng Pu, Rensong Yue, Rensong Yue   +13 more
doaj   +1 more source

Identification and Exploration of Immunity‐Related Genes and Natural Products for Alzheimer's Disease Based on Bioinformatics, Molecular Docking, and Molecular Dynamics

Immunity, Inflammation and Disease, Volume 13, Issue 4, April 2025.
We used a variety of methods to identify biomarkers and compounds of Alzheimer's disease, providing new insights into the clinical research transformation of Alzheimer's disease. ABSTRACT Background Recent research highlights the immune system's role in AD pathogenesis and promising prospects of natural compounds in treatment.
Pengpeng Liang, Yale Wang, Jiamin Liu, Hai Huang, Yue Li, Jinhua Kang, Guiyun Li, Hongyan Wu   +7 more
wiley   +1 more source

From Profiles to Structure in Cochlear Nerve: A Clinical Study of Auditory Neuropathy

Laryngoscope Investigative Otolaryngology, Volume 10, Issue 2, April 2025.
The purpose of our study was to investigate clinical and audiological characteristics in patients with different imaging features of cochlear nerve (CN) on MRI and to provide a reference for building prediction models. The results showed that some audiological indicators, such as pure‐tone hearing threshold and rate of elicitation on DPOAE, related to ...
Danyang Li, Hongyang Wang, Mengtao Song, Lan Lan, Linyi Xie, Fen Xiong, Jin Li, Yiming Li, Rui Zhou, Xiaolong Zhang, Qiuju Wang   +10 more
wiley   +1 more source

Actin dynamics at the immunological synapse

Cell Health and Cytoskeleton, 2010
Mónica Gordón-Alonso, Esteban Veiga, Francisco Sánchez-MadridServicio de Inmunología, Hospital Universitario de la Princesa and Facultad de Medicina, Universidad Autónoma de Madrid, Diego de León, Madrid, SpainAbstract: Actins are a family of highly conserved proteins that play ...
Mónica Gordón-Alonso, Francisco Sánchez-Madrid, Esteban Veiga   +2 more
openaire   +3 more sources

Formation of dilute adhesion domains driven by weak elasticity-mediated interactions [PDF]

arXiv, 2016
Cell-cell adhesion is established by specific binding of receptor and ligand proteins. The adhesion bonds attract each other and often aggregate into large clusters that are central to many biological processes. One possible origin of attractive interactions between adhesion bonds is the elastic response of the membranes to their deformation by the ...
arxiv  

The Myotubularin Related Proteins and the Untapped Interaction Potential of Their Disordered C‐Terminal Regions

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 4, Page 831-854, April 2025.
ABSTRACT Intrinsically disordered regions (IDRs) of proteins remain understudied with enigmatic sequence features relevant to their functions. Members of the myotubularin‐related protein (MTMR) family contain uncharacterized IDRs. After decades of research on their phosphatase activity, recent work on the C‐terminal IDRs of MTMR7 revealed new ...
Daniel Saar, Caroline L. E. Lennartsson, Philip Weidner, Elke Burgermeister, Birthe B. Kragelund   +4 more
wiley   +1 more source

Formation and function of the immunological synapse

Current Opinion in Immunology, 2002
Less than five years ago it was reported that cell surface molecules at the contact site between CD4 T cells and antigen-presenting cells redistribute into distinct patterns, forming an organized interface termed the immunological synapse. More recently, similar reorganized interfaces have been observed with CD8 T cells and NK cells, suggesting that ...
openaire   +4 more sources

The Immunological Synapse and Actin Assembly [PDF]

Developmental Cell, 2003
Engagement of the T cell receptor leads to the accumulation of filamentous actin, which is necessary for the formation of the immunological synapse and subsequent T cell activation. In the December issue of Molecular Cell, Sasahara et al. provide new insights into the link between the T cell receptor and actin assembly in the immunological synapse, and
openaire   +2 more sources

Human in vitro-induced regulatory T cells display Dlgh1 dependent and PKC-θ restrained suppressive activity

Scientific Reports, 2017
In vitro induced human regulatory T cells (iTregs) have demonstrated in vivo therapeutic utility, but pathways regulating their function have not been elucidated.
Alexandra Zanin-Zhorov, Sudha Kumari, Keli L. Hippen, Sarah C. Merkel, Margaret L. MacMillan, Bruce R. Blazar, Michael L. Dustin   +6 more
doaj   +1 more source

The ultrastructural and proteomic analysis of mitochondria‐associated endoplasmic reticulum membrane in the midbrain of a Parkinson's disease mouse model

Aging Cell, Volume 24, Issue 4, April 2025.
In MPTP‐induced PD mouse models, transmission electron microscopy was applied for MAM ultrastructural visualization. Nano ultra‐high performance liquid chromatography‐tandem mass spectrum and bioinformatic analysis were adopted to obtain the underlying molecular data of MAM fractions.
Jin Liu, Yi Liu, Chao Gao, Hong Pan, Pei Huang, Yuyan Tan, Shengdi Chen   +6 more
wiley   +1 more source