Results 111 to 120 of about 462,461 (237)
Formation and function of the immunological synapse
Current Opinion in Immunology, 2002 Less than five years ago it was reported that cell surface molecules at the contact site between CD4 T cells and antigen-presenting cells redistribute into distinct patterns, forming an organized interface termed the immunological synapse. More recently, similar reorganized interfaces have been observed with CD8 T cells and NK cells, suggesting that ...
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Actin dynamics at the immunological synapse
Cell Health and Cytoskeleton, 2010 Mónica Gordón-Alonso, Esteban Veiga, Francisco Sánchez-MadridServicio de Inmunología, Hospital Universitario de la Princesa and Facultad de Medicina, Universidad Autónoma de Madrid, Diego de León, Madrid, SpainAbstract: Actins are a family of highly conserved proteins that play ...
Mónica Gordón-Alonso +2 more
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Membrane trafficking of synaptic adhesion molecules
The Journal of Physiology, EarlyView.Abstract figure legend Synaptic cellular adhesion molecules are surface transmembrane receptors that have been shown to internalize via endocytosis, and possibly also recycle, in a process that has been linked to the function and the turnover of the synaptic contact site.
Cristian A. Bogaciu, Silvio O. Rizzoli
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Frontiers in Immunology, 2017 The Warts, Hypogammaglobulinemia, Infections, Myelokathexis (WHIM) syndrome is an immunodeficiency caused by mutations in chemokine receptor CXCR4. WHIM patient adaptive immunity defects remain largely unexplained.
Giuliana Roselli +7 more
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The Journal of Physiology, EarlyView.Abstract figure legend The glia‐immune network involves the communication(s) of glia via immune signalling pathways. In neuro‐homeostasis these pathways have been shown to modulate key processes such as synaptic pruning and myelination. The dynamics of these processes is critical to CNS function.
Verity F. T. Mitchener +2 more
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The Immunological Synapse and Actin Assembly [PDF]
Developmental Cell, 2003 Engagement of the T cell receptor leads to the accumulation of filamentous actin, which is necessary for the formation of the immunological synapse and subsequent T cell activation. In the December issue of Molecular Cell, Sasahara et al. provide new insights into the link between the T cell receptor and actin assembly in the immunological synapse, and
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ICAM-1 enhances MHC-peptide activation of CD8+ T cells without an organized immunological synapse [PDF]
, 2000 Julia Goldstein +4 more
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Glia, Volume 73, Issue 8, Page 1746-1766, August 2025.Main Points Microglial NF‐kB signaling increases M1‐like spinal microglia over time after spinal cord injury. Microglial NF‐kB signaling broadly affects gene expression in spinal cord. Microglial NF‐kB signaling modulates splenocytes acutely after spinal cord injury.
Micaela L. O'Reilly +8 more
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Scientific Reports, 2017 In vitro induced human regulatory T cells (iTregs) have demonstrated in vivo therapeutic utility, but pathways regulating their function have not been elucidated.
Alexandra Zanin-Zhorov +6 more
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The Sunrise of Tertiary Lymphoid Structures in Cancer
Immunological Reviews, Volume 332, Issue 1, July 2025.ABSTRACT First considered as a negative epiphenomenon in autoimmune and inflammatory diseases, with possible deleterious consequences through the production of pathological autoantibodies and antiself T cells, tertiary lymphoid structures (TLS) have gained major scientific and clinical interest in cancer due to their association with better clinical ...
Juliette Rochefort +3 more
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