Results 121 to 130 of about 15,575 (197)

A correlative and quantitative imaging approach enabling characterization of primary cell-cell communication: Case of human CD4+ T cell-macrophage immunological synapses [PDF]

, 2018
Cell-to-cell communication engages signaling and spatiotemporal reorganization events driven by highly context-dependent and dynamic intercellular interactions, which are difficult to capture within heterogeneous primary cell cultures. Here, we present a
A Grakoui, AT Ritter, B Molon, BF Lillemeier, C Blanpain, C Kummerow, C Wulfing, CA Schneider, CR Monks, DM Underhill, DR Fooksman, EA Rinnooy Kan, GA Azar, H Mo, H Shirvani, HD Moreau, J Hesselgesser, JM Fox, JM Fox, K Choudhuri, KA Markey, LD Bennett, M Kallikourdis, M Perez-Martinez, M Tourret, ML Dustin, ML Dustin, ML Dustin, ML Misfeldt, MM Morgan, N Martinez-Martin, NB Martin-Cofreces, P Friedl, R Barreira da Silva, RE Dolmetsch, RL Contento, RS Friedman, S Celli, S Duchez, SC Bunnell, SN Christo, SW Burchiel, TJ Thauland, WR Burack, WT Lee, ZA Mohammed   +45 more
core   +1 more source

Mind the GAPS: Glia associated with psychological stress

Journal of Neuroendocrinology, EarlyView.
Abstract Glial cells are an integral component of the nervous system, performing crucial functions that extend beyond structural support, including modulation of the immune system, tissue repair, and maintaining tissue homeostasis. Recent studies have highlighted the importance of glial cells as key mediators of stress responses across different organs.
Niklas Blank, Molly Weiner, Shaan Patel, Sarah Köhler, Christoph A. Thaiss   +4 more
wiley   +1 more source

Human in vitro-induced regulatory T cells display Dlgh1 dependent and PKC-θ restrained suppressive activity

Scientific Reports, 2017
In vitro induced human regulatory T cells (iTregs) have demonstrated in vivo therapeutic utility, but pathways regulating their function have not been elucidated.
Alexandra Zanin-Zhorov, Sudha Kumari, Keli L. Hippen, Sarah C. Merkel, Margaret L. MacMillan, Bruce R. Blazar, Michael L. Dustin   +6 more
doaj   +1 more source

CXCL12 Mediates Aberrant Costimulation of B Lymphocytes in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Immunodeficiency

Frontiers in Immunology, 2017
The Warts, Hypogammaglobulinemia, Infections, Myelokathexis (WHIM) syndrome is an immunodeficiency caused by mutations in chemokine receptor CXCR4. WHIM patient adaptive immunity defects remain largely unexplained.
Giuliana Roselli, Elisa Martini, Vassilios Lougaris, Raffaele Badolato, Antonella Viola, Antonella Viola, Marinos Kallikourdis, Marinos Kallikourdis   +7 more
doaj   +1 more source

An introduction to the immune network [PDF]

arXiv, 1995
In this paper, after a telegraphic introduction to modern immunology, we present a simple model for the idiotypic network among antibodies and we study its relevance for the maintenance of immunological memory. We also consider the problem of computing the memory capacity of such a model.
arxiv  

Updated insights into the molecular pathogenesis of canine atopic dermatitis

Veterinary Dermatology, EarlyView.
Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley   +1 more source

Shannon Information Capacity of Discrete Synapses [PDF]

arXiv, 2008
There is evidence that biological synapses have only a fixed number of discrete weight states. Memory storage with such synapses behaves quite differently from synapses with unbounded, continuous weights as old memories are automatically overwritten by new memories.
arxiv  

Cutting Edge: The Dendritic Cell Cytoskeleton Is Critical for the Formation of the Immunological Synapse [PDF]

, 2001
Monther Al‐Alwan, Geoffrey Rowden, Timothy D.G. Lee, Kenneth A. West   +3 more
openalex   +1 more source

Presynaptic quantal size enhancement counteracts post‐tetanic release depression

The Journal of Physiology, EarlyView.
Abstract figure legend Sustained high‐frequency stimulation decreases the number of synaptic vesicles that fuse per action potential at the Drosophila neuromuscular junction. However, the postsynaptic response remains largely unchanged. An increased postsynaptic response to individual vesicles, likely driven by an increase in vesicle size resulting ...
Anu G. Nair, Nasrin Bollmohr, Levin Schökle, Jennifer Keim, José María Mateos Melero, Martin Müller   +5 more
wiley   +1 more source

Interplay of Polarity Proteins and GTPases in T-Lymphocyte Function

Clinical and Developmental Immunology, 2012
Polarity refers to the asymmetric distribution of different cellular components within a cell and is central to many cell functions. In T-cells, polarity regulates the activation, migration, and effector function of cytotoxic T-cells (CTLs) during an ...
Ivan Fung, Sarah M. Russell, Jane Oliaro
doaj   +1 more source