Results 131 to 140 of about 30,755 (231)

Therapeutic Effects of Noninvasive Electrical Stimulation in Combination Transplantation of Human Adipose‐Derived Stem Cells‐Derived Dopaminergic Neuron on the Monkey Model of Parkinson's Disease

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Our results showed that noninvasive electrical stimulation (NES) alone or in combination with human adipose‐derived stem cells (hADSCs)‐induced dopaminergic neuron (NES‐DN) improved the behavioral deficits and pathological features of the MPTP‐induced PD monkey model.
Chunhui Huang   +21 more
wiley   +1 more source

immunological synapse

open access: yes
Citation: 'immunological synapse' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13301 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms ...
openaire   +1 more source

D1/D5 receptor activation promotes long‐term potentiation and synaptic tagging/capture in hippocampal area CA2

open access: yesThe FEBS Journal, Volume 293, Issue 3, Page 766-780, February 2026.
Activation of dopamine receptor D1 (D1R) stimulates PKA and ERK pathways via dissociation of stimulatory and olfactory G protein alpha subunits (Gαs/olf). PKA relieves striatal‐enriched protein tyrosine phosphatase (STEP) inhibition of ERK, promoting cyclic adenosine monophosphate response element‐binding protein (CREB)‐driven transcription of ...
Kevin Chua   +2 more
wiley   +1 more source

Preliminary Studies on the Use of Monoclonal Antibodies as Probes for Sympathetic Development [PDF]

open access: yes, 1980
The precise structural organization and proper functioning of the adult nervous system depend on the ability of neurones to make highly ordered synaptic connexions.
Cantor, Harvey   +2 more
core  

TRPM8 Regulates Mitochondrial Ca2+‐Dynamics, Temperature and Endoplasmic Reticulum‐Mitochondrial Contact Points in T Cell

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT TRPM8 is a cold temperature‐sensitive and non‐selective Ca2+‐channel. Previously we have observed that TRPM8 is endogenously expressed and affects T cell activation process. Now, we report that TRPM8 regulates functions of mitochondria and ER, two important sub‐cellular compartments.
Tusar Kanta Acharya   +5 more
wiley   +1 more source

Interplay of Polarity Proteins and GTPases in T-Lymphocyte Function

open access: yesClinical and Developmental Immunology, 2012
Polarity refers to the asymmetric distribution of different cellular components within a cell and is central to many cell functions. In T-cells, polarity regulates the activation, migration, and effector function of cytotoxic T-cells (CTLs) during an ...
Ivan Fung, Sarah M. Russell, Jane Oliaro
doaj   +1 more source

Functional role of UNC13D in immune diseases and its therapeutic applications

open access: yesFrontiers in Immunology
UNC13 family (also known as Munc13) proteins are evolutionarily conserved proteins involved in the rapid and regulated secretion of vesicles, including synaptic vesicles and cytotoxic granules.
Van-Thanh Duong   +4 more
doaj   +1 more source

Impact of Microglia in Neurodevelopmental Disorders: A Review

open access: yesBiomedical Sciences and Clinical Medicine
OBJECTIVE Microglia, immune cells that dwell in the brain, have essential functions in neurodevelopment and are responsible for synaptic pruning, neuronal circuit creation, and inflammatory responses.
Pushpalatha K   +6 more
doaj   +1 more source

Lipid switches in the immunological synapse

open access: yesJournal of Biological Chemistry
Adaptive immune responses comprise the activation of T cells by peptide antigens that are presented by proteins of the Major Histocompatibility Complex (MHC) on the surface of an antigen-presenting cell. As a consequence of the T cell receptor interacting productively with a certain peptide-MHC complex, a specialized cell-cell junction known as the ...
Griffiths, Gillian   +2 more
openaire   +3 more sources

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