Results 11 to 20 of about 13,144 (238)

An Effective Membrane Model of the Immunological Synapse [PDF]

Physical Review Letters, 2003
The immunological synapse is a patterned collection of different types of receptors and ligands that forms in the intercellular junction between T Cells and antigen presenting cells (APCs) during recognition. The synapse is implicated in information transfer between cells, and is characterized by different spatial patterns of receptors at different ...
Arup K. Chakraborty, Arup K. Chakraborty, Mehran Kardar, Subhadip Raychaudhuri   +3 more
arxiv   +6 more sources

The dendritic cell side of the immunological synapse [PDF]

Biomolecular Concepts, 2016
Immune responses are initiated by the interactions between antigen-presenting cells (APCs), such as dendritic cells (DCs), with responder cells, such as T cells, via a tight cellular contact interface called the immunological synapse.
Verboogen Danielle R.J., Dingjan Ilse, Revelo Natalia H., Visser Linda J., ter Beest Martin, van den Bogaart Geert   +5 more
doaj   +6 more sources

Chemokines and the immunological synapse

Immunology, 2002
The critical event which initiates an adaptive immune response is the interaction of T cells through the T-cell antigen receptor (TCR) with major histocompatibility complex (MHC)–peptide (MHCp) complexes on the surface of antigen-presenting cells (APCs).
Victor L. J. Tybulewicz
openalex   +4 more sources

Cytotoxic immunological synapses. [PDF]

Immunol Rev, 2010
Summary:  One of the most fundamental activities of the adaptive immune system is to kill infected cells and tumor cells. Two distinct pathways mediate this process, both of which are facilitated by a cytotoxic immunological synapse. While traditionally thought of as innate immune cells, natural killer (NK) cells are now appreciated to have the ...
Dustin ML, Long EO.
europepmc   +6 more sources

Immunological synapses in infectious diseases [PDF]

Brazilian Journal of Infectious Diseases, 2007
Rodrigo Siqueira-Batista, Mauro Geller, Andréia Patrícia Gomes   +2 more
doaj   +4 more sources

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

The Nanoscopic Organization of Synapse Structures: A Common Basis for Cell Communication

Membranes, 2021
Synapse structures, including neuronal and immunological synapses, can be seen as the plasma membrane contact sites between two individual cells where information is transmitted from one cell to the other. The distance between the two plasma membranes is
Xiaojuan Yang, Wim Annaert
doaj   +1 more source

Circadian modulation of microglial physiological processes and immune responses

Glia, Volume 71, Issue 2, Page 155-167, February 2023., 2023
Main Points Microglia are rhythmic cells with an oscillatory expression in clock genes, cytokines, and other microglial markers. Microglial circadian rhythms determine their physiological function and immune responses. Abstract Microglia is considered the central nervous system (CNS) resident macrophages that establish an innate immune response against
Mara A. Guzmán‐Ruiz, Natalí N. Guerrero‐Vargas, Alejandra Lagunes‐Cruz, Shellye González‐González, Jesús Enrique García‐Aviles, Gabriela Hurtado‐Alvarado, Rebeca Mendez‐Hernández, Anahí Chavarría‐Krauser, Jean‐Pascal Morin, Virginia Arriaga‐Avila, Ruud M. Buijs, Rosalinda Guevara‐Guzmán   +11 more
wiley   +1 more source

Deletion of MyD88 in astrocytes prevents β‐amyloid‐induced neuropathology in mice

Glia, Volume 71, Issue 2, Page 431-449, February 2023., 2023
Main Points MyD88 is upregulated in astrocytes in Alzheimer's disease. Deletion of MyD88 in astrocytes protects against β‐amyloid‐induced synaptic toxicity and cognitive impairment in mice. Abstract As the understanding of immune responses in Alzheimer's disease (AD) is in its early phases, there remains an urgency to identify the cellular and ...
Tee Jong Huat, Tessa Onraet, Judith Camats‐Perna, Estella A. Newcombe, Kim C. Ngo, Ashley N. Sue, Mehdi Mirzaei, Frank M. LaFerla, Rodrigo Medeiros   +8 more
wiley   +1 more source

The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection

Nature Communications, 2022
HIV infection over time is thought to result in premature aging and aberrant immune responses including the induction of immunological senescence. Here the authors show altered formation of immune synapses by naive CD8+ T cells and dysregulated synapse ...
Nadia Anikeeva, Maria Steblyanko, Leticia Kuri-Cervantes, Marcus Buggert, Michael R. Betts, Yuri Sykulev   +5 more
doaj   +1 more source