Results 11 to 20 of about 462,461 (237)

Cytotoxic immunological synapses. [PDF]

Immunol Rev, 2010
Summary:  One of the most fundamental activities of the adaptive immune system is to kill infected cells and tumor cells. Two distinct pathways mediate this process, both of which are facilitated by a cytotoxic immunological synapse. While traditionally thought of as innate immune cells, natural killer (NK) cells are now appreciated to have the ...
Dustin ML, Long EO.
europepmc   +7 more sources

Modular design of immunological synapses and kinapses. [PDF]

Cold Spring Harb Perspect Biol, 2009
The concept of an immunological synapse goes back to the early 1980s with the discovery of the relationship between T-cell antigen receptor mediated Ca(2+) signaling, adhesion, and directed secretion.
Dustin ML.
europepmc   +2 more sources

Self-reactive human CD4 T cell clones form unusual immunological synapses. [PDF]

J Exp Med, 2012
Compared with influenza-specific T cells, self-reactive T cells from patients with multiple sclerosis or type 1 diabetes fail to slow down and do not form normal immunological synapses upon encounter with cognate self-peptide presented by MHC.
Schubert DA, Gordo S, Sabatino JJ, Vardhana S, Gagnon E, Sethi DK, Seth NP, Choudhuri K, Reijonen H, Nepom GT, Evavold BD, Dustin ML, Wucherpfennig KW.   +12 more
europepmc   +2 more sources

A potential prognostic marker for hematologic neoplasms: CD58 [PDF]

Frontiers in Oncology
CD58 is a glycoprotein receptor widely distributed on histiocytes that binds to CD2, that takes part in constituting the Immunological Synapses (IS) and activating T/NK cells.
Jiajia Cao, Yurong Zhang, Ningning Yue, Shuzhen Xiong, Shuni Zhang, Chongyang Wu   +5 more
doaj   +2 more sources

LFA-1 Activation in T-Cell Migration and Immunological Synapse Formation

Cells, 2023
Integrin LFA-1 plays a critical role in T-cell migration and in the formation of immunological synapses. LFA-1 functions through interacting with its ligands with differing affinities: low, intermediate, and high.
Huiping Shi, Bojing Shao
doaj   +2 more sources

Immunological synapse formation between T regulatory cells and cancer-associated fibroblasts promotes tumour development

Nature Communications
Cancer-associated fibroblasts (CAFs) have emerged as a dominant non-hematopoietic cell population in the tumour microenvironment, serving diverse functions in tumour progression.
Athina Varveri, Miranta Papadopoulou, Zacharias Papadovasilakis, Ewoud B. Compeer, Aigli-Ioanna Legaki, Anastasios Delis, Vasileia Damaskou, Louis Boon, Sevasti Papadogiorgaki, Martina Samiotaki, Periklis G. Foukas, Aristides G. Eliopoulos, Aikaterini Hatzioannou, Themis Alissafi, Michael L. Dustin, Panayotis Verginis   +15 more
doaj   +2 more sources

In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain [PDF]

Journal of Experimental Medicine, 2006
The microanatomy of immune clearance of infected brain cells remains poorly understood. Immunological synapses are essential anatomical structures that channel information exchanges between T cell–antigen-presenting cells (APC) during the priming and ...
Carlos Barcia, Clare E. Thomas, James F. Curtin, Gwendalyn D. King, Kolja Wawrowsky, Marianela Candolfi, Weidong Xiong, Chunyan Liu, Kurt M. Kroeger, Olivier Boyer, Jerzy W. Kupiec‐Weglinski, David Klatzmann, María G. Castro, Pedro R. Löwenstein   +13 more
openalex   +2 more sources

Evolving immune circuits are generated by flexible, motile, and sequential immunological synapses. [PDF]

Immunol Rev, 2013
Gérard A, Beemiller P, Friedman RS, Jacobelli J, Krummel MF.   +4 more
europepmc   +2 more sources

Infiltrating CTLs in human glioblastoma establish immunological synapses with tumorigenic cells. [PDF]

Am J Pathol, 2009
The immunological synapse between T cells and tumor cells is believed to be important for effective tumor clearance. However, the immunological synapse has never been imaged or analyzed in detail in human tissue.
Barcia C, Gómez A, Gallego-Sanchez JM, Perez-Vallés A, Castro MG, Lowenstein PR, Barcia C, Herrero MT.   +7 more
europepmc   +2 more sources

Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses

BMC Research Notes, 2011
Background CD99, a leukocyte surface glycoprotein, is broadly expressed in many cell types. On the cell surface, CD99 is expressed as two distinct isoforms, a long form and a short form. CD99 has been demonstrated to play a key role in several biological
Pata Supansa, Otáhal Pavel, Brdička Tomáš, Laopajon Witida, Mahasongkram Kodchakorn, Kasinrerk Watchara   +5 more
doaj   +2 more sources