Results 11 to 20 of about 30,755 (231)

Cytotoxic immunological synapses. [PDF]

open access: yesImmunol Rev, 2010
Summary:  One of the most fundamental activities of the adaptive immune system is to kill infected cells and tumor cells. Two distinct pathways mediate this process, both of which are facilitated by a cytotoxic immunological synapse. While traditionally thought of as innate immune cells, natural killer (NK) cells are now appreciated to have the ...
Dustin ML, Long EO.
europepmc   +5 more sources

Immunological synapses in infectious diseases [PDF]

open access: yesBrazilian Journal of Infectious Diseases, 2007
Rodrigo Siqueira-Batista   +2 more
doaj   +3 more sources

The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection

open access: yesNature Communications, 2022
HIV infection over time is thought to result in premature aging and aberrant immune responses including the induction of immunological senescence. Here the authors show altered formation of immune synapses by naive CD8+ T cells and dysregulated synapse ...
Nadia Anikeeva   +5 more
doaj   +1 more source

Deterministic mechanical model of T-killer cell polarization reproduces the wandering of aim between simultaneously engaged targets [PDF]

open access: yes, 2009
T-killer cells of the immune system eliminate virus-infected and tumorous cells through direct cell-cell interactions. Reorientation of the killing apparatus inside the T cell to the T-cell interface with the target cell ensures specificity of the immune
A Ashkin   +23 more
core   +11 more sources

LFA-1 Activation in T-Cell Migration and Immunological Synapse Formation

open access: yesCells, 2023
Integrin LFA-1 plays a critical role in T-cell migration and in the formation of immunological synapses. LFA-1 functions through interacting with its ligands with differing affinities: low, intermediate, and high.
Huiping Shi, Bojing Shao
doaj   +1 more source

Immune-mediated loss of transgene expression from virally transduced brain cells is irreversible, mediated by IFNγ, perforin, and TNFα, and due to the elimination of transduced cells [PDF]

open access: yes, 2012
The adaptive immune response to viral vectors reduces vector-mediated transgene expression from the brain. It is unknown, however, whether this loss is caused by functional downregulation of transgene expression or death of transduced cells.
Ahmed   +60 more
core   +1 more source

The Immunological Synapse [PDF]

open access: yesCancer Immunology Research, 2003
AbstractThe molecular interactions underlying regulation of the immune response take place in a nanoscale gap between T cells and antigen-presenting cells, termed the immunological synapse. If these interactions are regulated appropriately, the host is defended against a wide range of pathogens and deranged host cells.
openaire   +6 more sources

The Immunological Synapse

open access: yesAnnual Review of Immunology, 2001
The adaptive immune response is initiated by the interaction of T cell antigen receptors with major histocompatibility complex molecule-peptide complexes in the nanometer scale gap between a T cell and an antigen-presenting cell, referred to as an immunological synapse.
Bromley, S   +9 more
openaire   +3 more sources

T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: a novel astrocyte response mechanism to cellular injury.

open access: yesPLoS ONE, 2008
BackgroundAstrocytes usually respond to trauma, stroke, or neurodegeneration by undergoing cellular hypertrophy, yet, their response to a specific immune attack by T cells is poorly understood.
Carlos Barcia   +8 more
doaj   +1 more source

Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue. [PDF]

open access: yes, 1981
Two different monoclonal antibodies, characterized initially as binding synaptic terminal regions of rat brain, bind a 65,000-dalton protein, which is exposed on the outer surface of brain synaptic vesicles. Immunocytochemical experiments at the electron
Matthew, WD, Reichardt, LF, Tsavaler, L
core   +2 more sources

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