Results 31 to 40 of about 13,144 (238)
Information transfer at the immunological synapse [PDF]
Current Biology, 2000 Antigen-specific activation of T lymphocytes requires the interaction of their clonally distributed T-cell receptors with plasma membrane ligands composed of foreign peptide antigens bound to major histocompatibility complex molecules. For proliferation and differentiation to ensue, a variety of other adhesive and accessory proteins must also interact ...
Ronald N. Germain, Jérôme Delon
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Inhibitory receptor signaling destabilizes immunological synapse formation in primary NK cells
Frontiers in Immunology, 2013 Upon engagement of their cognate class I major histocompatibility complex (MHC) ligands, receptors containing immunotyrosine-based inhibitory motifs (ITIMs) transduce signals that block cytolytic and inflammatory responses.
Thushara P Abeyweera +2 more
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What is an immunological synapse?
Microbes and Infection, 2010 Immunological synapses (IS) are emerging as highly organized 3D structures -formed by surface and cytoplasmic signalling and cytoskeletal molecules - that assemble at the zone of contact between a T cell and an antigen presenting cell (APC). The IS control functions that allow APC and T cells modulate the immune response.
Rodríguez-Fernández, José Luis +2 more
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Actin Engine in Immunological Synapse [PDF]
Immune Network, 2012 T cell activation and function require physical contact with antigen presenting cells at a specialized junctional structure known as the immunological synapse. Once formed, the immunological synapse leads to sustained T cell receptor-mediated signalling and stabilized adhesion.
Indre Piragyte, Chang-Duk Jun
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Close contact fluctuations: the seeding of signalling domains in the immunological synapse [PDF]
Europhysics Letters 77, 48003 (2007), 2006 We analyse the size and density of thermally induced regions of close contact in cell:cell contact interfaces within a harmonic potential approximation, estimating these regions to be below one-tenth of a micron across. Our calculations indicate that as the distance between the close contact threshold depth and the mean membrane-membrane separation ...
arxiv +1 more source
Synaptoimmunology - roles in health and disease
Molecular Brain, 2017 Mounting evidence suggests that the nervous and immune systems are intricately linked. Many proteins first identified in the immune system have since been detected at synapses, playing different roles in normal and pathological situations.
Robert Nisticò +8 more
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The role of the cytoskeleton at the immunological synapse [PDF]
Immunological Reviews, 2013 SummaryIt has been over 30 years since the reorganization of both the microtubule network and a ‘peculiar actin polarization’ was reported at the contact area of cytotoxic T lymphocytes interacting with target cells. Since that time, hundreds of studies have been published in an effort to elucidate the structure and function of the microtubule network ...
Karen L. Angus +2 more
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Three-Dimensional Gradients of Cytokine Signaling between T Cells.
PLoS Computational Biology, 2015 Immune responses are regulated by diffusible mediators, the cytokines, which act at sub-nanomolar concentrations. The spatial range of cytokine communication is a crucial, yet poorly understood, functional property. Both containment of cytokine action in
Kevin Thurley +3 more
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Stochastic model of T Cell repolarization during target elimination (II) [PDF]
, 2021 Cytotoxic T lymphocytes (T cells) and natural killer cells form a tight contact, the immunological synapse (IS), with target cells, where they release their lytic granules containing perforin/granzyme and cytokine containing vesicles. During this process the cell repolarizes and moves the microtubule organizing center (MTOC) towards the IS.
arxiv +1 more source