Results 31 to 40 of about 462,461 (237)
The Nanoscopic Organization of Synapse Structures: A Common Basis for Cell Communication
Membranes, 2021 Synapse structures, including neuronal and immunological synapses, can be seen as the plasma membrane contact sites between two individual cells where information is transmitted from one cell to the other. The distance between the two plasma membranes is
Xiaojuan Yang, Wim Annaert
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The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection
Nature Communications, 2022 HIV infection over time is thought to result in premature aging and aberrant immune responses including the induction of immunological senescence. Here the authors show altered formation of immune synapses by naive CD8+ T cells and dysregulated synapse ...
Nadia Anikeeva +5 more
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Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica +6 more
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Imaging the Human Immunological Synapse [PDF]
Journal of Visualized Experiments, 2019 The purpose of the method is to generate an immunological synapse (IS), an example of cell-to-cell conjugation formed by an antigen-presenting cell (APC) and an effector helper T lymphocyte (Th) cell, and to record the images corresponding to the first stages of the IS formation and the subsequent trafficking events (occurring both in the APC and in ...
Bello-Gamboa, Ana +8 more
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The Immunological Synapse [PDF]
Cancer Immunology Research, 2003 AbstractThe molecular interactions underlying regulation of the immune response take place in a nanoscale gap between T cells and antigen-presenting cells, termed the immunological synapse. If these interactions are regulated appropriately, the host is defended against a wide range of pathogens and deranged host cells.
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A Ciliary View of the Immunological Synapse [PDF]
Cells, 2019 The primary cilium has gone from being a vestigial organelle to a crucial signaling hub of growing interest given the association between a group of human disorders, collectively known as ciliopathies, and defects in its structure or function. In recent years many ciliogenesis proteins have been observed at extraciliary sites in cells and likely ...
Cassioli, Chiara, Baldari, Cosima T
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Annual Review of Immunology, 2001 The adaptive immune response is initiated by the interaction of T cell antigen receptors with major histocompatibility complex molecule-peptide complexes in the nanometer scale gap between a T cell and an antigen-presenting cell, referred to as an immunological synapse.
Bromley, S +9 more
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Frontiers in Cell and Developmental Biology, 2021 Natural killer (NK) cells are innate lymphoid cells, which play key roles in elimination of virally infected and malignant cells. The balance between activating and inhibitory signals derived from NK surface receptors govern the NK cell immune response ...
Aviad Ben-Shmuel +3 more
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What is an immunological synapse?
Microbes and Infection, 2010 Immunological synapses (IS) are emerging as highly organized 3D structures -formed by surface and cytoplasmic signalling and cytoskeletal molecules - that assemble at the zone of contact between a T cell and an antigen presenting cell (APC). The IS control functions that allow APC and T cells modulate the immune response.
Rodríguez-Fernández, José Luis +2 more
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Information transfer at the immunological synapse [PDF]
Current Biology, 2000 Antigen-specific activation of T lymphocytes requires the interaction of their clonally distributed T-cell receptors with plasma membrane ligands composed of foreign peptide antigens bound to major histocompatibility complex molecules. For proliferation and differentiation to ensue, a variety of other adhesive and accessory proteins must also interact ...
Ronald N. Germain, Jérôme Delon
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