Results 31 to 40 of about 30,755 (231)
PPARγ and LXR Signaling Inhibit Dendritic Cell-Mediated HIV-1 Capture and trans-Infection [PDF]
, 2010 Dendritic cells (DCs) contribute to human immunodeficiency virus type 1 (HIV-1) transmission and dissemination by capturing and transporting infectious virus from the mucosa to draining lymph nodes, and transferring these virus particles to CD4+ T cells ...
Blay Puryear, Wendy +3 more
core +5 more sources
Frontiers in Endocrinology, 2019 Based on the work in the Central Nervous System with discoveries of allosteric receptor-receptor interactions in homo- and heteroreceptor complexes representing a major integrative mechanism in synapses and extrasynaptic regions, it is proposed that a ...
Dasiel O. Borroto-Escuela +3 more
doaj +1 more source
Materials science: Breaking the neural code [PDF]
, 2002 The precise information that is conveyed between nerve cells remains unknown. Networks of nerve cells grown on silicon chips, using a polyester as a guide, may bring us closer to translating the elusive neural ...
Curtis, Adam
core +1 more source
Specific Adhesion of Membranes Simultaneously Supports Dual Heterogeneities in Lipids and Proteins [PDF]
, 2015 Membrane adhesion is a vital component of many biological processes. Heterogeneities in lipid and protein composition are often associated with the adhesion site. These heterogeneities are thought to play functional roles in facilitating signalling. Here
Gordon, Vernita D. +3 more
core +1 more source
Actin Engine in Immunological Synapse [PDF]
Immune Network, 2012 T cell activation and function require physical contact with antigen presenting cells at a specialized junctional structure known as the immunological synapse. Once formed, the immunological synapse leads to sustained T cell receptor-mediated signalling and stabilized adhesion.
Piragyte, Indre, Jun, Chang-Duk
openaire +2 more sources
ICAM-1 depletion in the center of immunological synapses is important for calcium releasing in T-cells [PDF]
Journal of Innovative Optical Health Sciences, 2018 T-cell activation requires the formation of the immunological synapse (IS) between a T-cell and an antigen-presenting cell (APC) to control the development of the adaptive immune response. However, calcium release, an initial signal of T-cell activation,
Yuanzhen Suo +7 more
doaj +1 more source
BMC Biology, 2011 Background Cytolytic cells of the immune system destroy pathogen-infected cells by polarised exocytosis of secretory lysosomes containing the pore-forming protein perforin. Precise delivery of this lethal hit is essential to ensuring that only the target
Arico Maurizo +5 more
doaj +1 more source
Haematologica, 2011 Background T-cell activation relies on the assembly of the immunological synapse, a structure tightly regulated by the actin cytoskeleton. The precise role of the Wiskott-Aldrich syndrome protein, an actin cytoskeleton regulator, in linking immunological
Ronan Calvez +5 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2020 Multispecific antibodies can be generated in different formats. More than two decades of R&D in the field of bispecific antibody engineering revealed that the design and choice of format can have a profound impact on the antibody functionality.
Steffen Dickopf +2 more
doaj +1 more source
High-Resolution Imaging of Natural Killer Cell Immunological Synapses
, 2011 The first observations of the immunological synapse have demonstrated that immune-cell signalling in situ does not simply depend on protein structures and signalling pathways but also on temporal and spatial coordinates. With the advent of new live-cell,
Oddos, Stephane, Oddos, Stephane
core +1 more source