Results 51 to 60 of about 462,461 (237)
Role of Drebrin at the Immunological Synapse [PDF]
, 2017 Although drebrin was first described in neurons, it is also expressed in cells of the immune system, such as T lymphocytes and mast cells. Another member of the drebrin family of proteins, mammalian actin-binding protein 1 (mAbp-1) is more widely expressed and plays important roles in the function of macrophages, polymorphonuclear neutrophils, and B ...
Vera Rocha-Perugini +2 more
openaire +3 more sources
BMC Biology, 2011 Background Cytolytic cells of the immune system destroy pathogen-infected cells by polarised exocytosis of secretory lysosomes containing the pore-forming protein perforin. Precise delivery of this lethal hit is essential to ensuring that only the target
Arico Maurizo +5 more
doaj +1 more source
Haematologica, 2011 Background T-cell activation relies on the assembly of the immunological synapse, a structure tightly regulated by the actin cytoskeleton. The precise role of the Wiskott-Aldrich syndrome protein, an actin cytoskeleton regulator, in linking immunological
Ronan Calvez +5 more
doaj +1 more source
Cell polarisation and the immunological synapse
Current Opinion in Cell Biology, 2013 Directed secretion by immune cells requires formation of the immunological synapse at the site of cell-cell contact, concomitant with a dramatic induction of cell polarity. Recent findings provide us with insights into the various steps that are required for these processes: for example, the first identification of a protein at the centrosome that ...
Gillian M. Griffiths, Karen L. Angus
openaire +3 more sources
Frontiers in Immunology, 2018 Background: Each year, over 5 million red blood cell (RBC) transfusions are administered to patients in the USA. Despite the therapeutic benefits of RBC transfusions, there are associated risks.
Amanda L. Richards +5 more
doaj +1 more source
Diversity in immunological synapse structure [PDF]
Immunology, 2010 SummaryImmunological synapses (ISs) are formed at the T cell–antigen‐presenting cell (APC) interface during antigen recognition, and play a central role in T‐cell activation and in the delivery of effector functions. ISs were originally described as a peripheral ring of adhesion molecules surrounding a central accumulation of T‐cell receptor (TCR ...
Timothy J. Thauland, David C. Parker
openaire +3 more sources
Down regulation of genes involved in T cell polarity and motility during the induction of heart allograft tolerance by allochimeric MHC I. [PDF]
PLoS ONE, 2009 BACKGROUND:The allochimeric MHC class I molecule [alpha1h1/u]-RT1.Aa that contains donor-type (Wistar Furth, WF; RT1u) epitopes displayed on recipient-type (ACI, RT1a) administered in conjunction with sub-therapeutic dose of cyclosporine (CsA) induces ...
Wojciech Lisik +7 more
doaj +1 more source
WASp Is Crucial for the Unique Architecture of the Immunological Synapse in Germinal Center B-Cells
Frontiers in Cell and Developmental Biology, 2021 B-cells undergo somatic hypermutation and affinity maturation in germinal centers. Somatic hypermutated germinal center B-cells (GCBs) compete to engage with and capture antigens on follicular dendritic cells.
Yanan Li +8 more
doaj +1 more source
Advanced Functional Materials, EarlyView.This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley +1 more source
Mechanical Communication at the Immunological Synapse [PDF]
Trends in Cell Biology, 2017 T and B lymphocytes communicate by forming immunological synapses with antigen-presenting target cells. These highly dynamic contacts are characterized by continuous cytoskeletal remodeling events, which not only structure the interface but also exert a considerable amount of mechanical force.
Morgan Huse, Roshni Basu
openaire +3 more sources