Results 51 to 60 of about 13,144 (238)
Role of Drebrin at the Immunological Synapse [PDF]
, 2017 Although drebrin was first described in neurons, it is also expressed in cells of the immune system, such as T lymphocytes and mast cells. Another member of the drebrin family of proteins, mammalian actin-binding protein 1 (mAbp-1) is more widely expressed and plays important roles in the function of macrophages, polymorphonuclear neutrophils, and B ...
Vera Rocha-Perugini +2 more
openaire +3 more sources
Mechanisms of B cell Synapse Formation Predicted by Stochastic Simulation [PDF]
, 2006 The clustering of B cell receptor (BCR) molecules and the formation of the protein segregation structure known as the immunological synapse appears to precede antigen (Ag) uptake by B cells. The mature B cell synapse is characterized by a central cluster of BCR/Ag molecular complexes surrounded by a ring of LFA-1/ICAM-1 complexes.
arxiv +1 more source
Cell polarisation and the immunological synapse
Current Opinion in Cell Biology, 2013 Directed secretion by immune cells requires formation of the immunological synapse at the site of cell-cell contact, concomitant with a dramatic induction of cell polarity. Recent findings provide us with insights into the various steps that are required for these processes: for example, the first identification of a protein at the centrosome that ...
Gillian M. Griffiths, Karen L. Angus
openaire +3 more sources
Frontiers in Immunology, 2018 Background: Each year, over 5 million red blood cell (RBC) transfusions are administered to patients in the USA. Despite the therapeutic benefits of RBC transfusions, there are associated risks.
Amanda L. Richards +5 more
doaj +1 more source
Search and capture efficiency of dynamic microtubules for centrosome relocation during IS formation [PDF]
Biophysical Journal (2019), 2019 Upon contact with antigen presenting cells (APCs) cytotoxic T lymphocytes (T cells) establish a highly organized contact zone denoted as immunological synapse (IS). The formation of the IS implies relocation of the microtubule organizing center (MTOC) towards the contact zone, which necessitates a proper connection between MTOC and IS via dynamic ...
arxiv +1 more source
Down regulation of genes involved in T cell polarity and motility during the induction of heart allograft tolerance by allochimeric MHC I. [PDF]
PLoS ONE, 2009 BACKGROUND:The allochimeric MHC class I molecule [alpha1h1/u]-RT1.Aa that contains donor-type (Wistar Furth, WF; RT1u) epitopes displayed on recipient-type (ACI, RT1a) administered in conjunction with sub-therapeutic dose of cyclosporine (CsA) induces ...
Wojciech Lisik +7 more
doaj +1 more source
Temporal dynamics in immunological synapse: Role of thermal fluctuations in signaling [PDF]
, 2016 The article analyzes the contribution of stochastic thermal fluctuations in the attachment times of the immature T-cell receptor TCR: peptide-major-histocompatibility-complex pMHC immunological synapse bond. The key question addressed here is the following: how does a synapse bond remain stabilized in the presence of high frequency thermal noise that ...
arxiv +1 more source
Elastohydrodynamics and kinetics of protein patterning in the immunological synapse [PDF]
, 2015 The cellular basis for the adaptive immune response during antigen recognition relies on a specialized protein interface known as the immunological synapse (IS). Understanding the biophysical basis for protein patterning by deciphering the quantitative rules for their formation and motion is an important aspect of characterizing immune cell recognition
arxiv +1 more source
Exact mean-field theory explains the dual role of electrical synapses in collective synchronization [PDF]
Phys. Rev. Lett. 125, 248101 (2020), 2020 Electrical synapses play a major role in setting up neuronal synchronization, but the precise mechanisms whereby these synapses contribute to synchrony are subtle and remain elusive. To investigate these mechanisms mean-field theories for quadratic integrate-and-fire neurons with electrical synapses have been recently put forward.
arxiv +1 more source
Regulatory T cells diminish transmission of HIV from Dendritic cells to conventional CD4+ T cells
Frontiers in Immunology, 2014 Formation of immunological synapses between dendritic cells (DC) and conventional CD4+ T cells (Tcon) is critical for productive immune responses. However, when DCs are HIV-infected such synapses are critical to establish HIV infection.
Maria Eugenia Moreno-Fernandez +3 more
doaj +1 more source