Results 71 to 80 of about 462,461 (237)

The immunological synapse as a pharmacological target

Pharmacological Research, 2018
The development of T cell mediated immunity relies on the assembly of a highly specialized interface between T cell and antigen presenting cell (APC), known as the immunological synapse (IS). IS assembly is triggered when the T cell receptor (TCR) binds to specific peptide antigen presented in association to the major histocompatibility complex (MHC ...
Finetti, Francesca, Baldari, Cosima T
openaire   +5 more sources

Dose Selection for DuoBody®‐CD40x4‐1BB (GEN1042/BNT312) Using a mPBPK/RO Model Leveraging Preclinical and Clinical Data

Clinical Pharmacology &Therapeutics, EarlyView.
Optimizing target engagement for bispecific antibodies (bsAbs) is challenging, as bsAbs bind to two different targets in vivo to form a trimolecular complex (trimer), and likely display a bell‐shaped concentration–response curve. bsAbs trimer formation is expected to be related to efficacy and safety, and determining the dose level at which it is ...
Gaurav Bajaj, Dmitry Shchelokov, Oleg Demin Jr, Homer C. Adams 3rd, Yan Feng, Leonid Gibiansky, Saskia van der Lee, Anandhi Johri, Merzu Belete, Alexander Muik, Porntula Panorchan, Özlem Türeci, Uğur Sahin, Tahamtan Ahmadi, Manish Gupta, Oleg Demin, Craig Thalhauser   +16 more
wiley   +1 more source

Antigen-specific suppression and immunological synapse formation by regulatory T cells require the Mst1 kinase. [PDF]

PLoS ONE, 2013
Although the cell-to-cell contact between CD4(+)Foxp3(+) regulatory T (Treg) and their target cells is important for the suppressor function of Treg cells, the regulation of this process is not well understood.
Takashi Tomiyama, Yoshihiro Ueda, Tomoya Katakai, Naoyuki Kondo, Kazuichi Okazaki, Tatsuo Kinashi   +5 more
doaj   +1 more source

Population dynamics of immunological synapse formation induced by bispecific T cell engagers predict clinical pharmacodynamics and treatment resistance

eLife, 2023
Effector T cells need to form immunological synapses (IS) with recognized target cells to elicit cytolytic effects. Facilitating IS formation is the principal pharmacological action of most T cell-based cancer immunotherapies. However, the dynamics of IS
Can Liu, Jiawei Zhou, Stephan Kudlacek, Timothy Qi, Tyler Dunlap, Yanguang Cao   +5 more
doaj   +1 more source

GABAergic synapses suppress intestinal innate immunity via insulin signaling in Caenorhabditis elegans

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance GABAergic signaling is crucial for the physiological function and the pathological onset of neuropsychiatric disorder, but its roles in innate immunity remain unknown.
Zhongfan Zheng, X. Zhang, Junqiang Liu, P. He, Shan Zhang, Yongning Zhang, Jie Gao, Shengmei Yang, Na Kang, M. I. Afridi, Shangbang Gao, Chunhong Chen, Haijun Tu   +12 more
semanticscholar   +1 more source

OMIP‐115: High‐Dimensional Phenotypic Characterization of Human Natural Killer Cells for Therapeutic Use

Cytometry Part A, EarlyView.
ABSTRACT This 29‐color flow cytometry panel was developed and optimized for in‐depth characterization of human peripheral blood NK cells for preclinical development and monitoring of NK cell therapies. The panel includes markers associated with NK cell differentiation, cytotoxicity, tissue residency, as well as NK cell dysfunction.
Emil Birch Christensen, Moritz Schaefer, Mike Bogetofte Barnkob, Christian Nielsen, Torben Barington   +4 more
wiley   +1 more source

Immunological Synapse

, 2015
Immunological synapses are dynamically organised cell–cell interfaces formed between cells of the immune system. Different types of immunological synapses lead to distinct functional outcomes. Thus, T and B lymphocytes form immunological synapses with each other and with dendritic cells or macrophages, conveying mutual activation cues.
Agüera-Gonzalez, Sonia, Bouchet, Jérôme, Alcover, Andrés   +2 more
openaire   +1 more source

Costimulation: Building an Immunological Synapse

Science, 1999
Immune responses are triggered by activation of the T cell receptor with foreign antigen. Dustin summarizes in his Perspective new evidence that this triggering event is actually the formation of an "immunological synapse," an area of close contact between cells. Recent results ( Viola et al.
Dustin, M, Shaw, A
openaire   +3 more sources

Are microglia minding us? Digging up the unconscious mind-brain relationship from a neuropsychoanalytic approach.

Frontiers in Human Neuroscience, 2013
The unconscious mind-brain relationship remains unresolved. From the perspective of neuroscience, neuronal networks including synapses have been dominantly believed to play crucial roles in human mental activities, while glial contribution to mental ...
Takahiro A. Kato, Takahiro A. Kato, Shigenobu eKanba   +2 more
doaj   +1 more source

HIV-1 intersection with CD4 T cell vesicle exocytosis: intercellular communication goes viral

Frontiers in Immunology, 2014
In cells of the immune system the secretion of extracellular vesicles is modulated through cellular activation. In particular, T cell activation is achieved through cell-cell contacts with antigen presenting cells and the consequent formation of a ...
Helena eSoares, Helena eSoares
doaj   +1 more source