Results 71 to 80 of about 13,144 (238)
eLife, 2023 Effector T cells need to form immunological synapses (IS) with recognized target cells to elicit cytolytic effects. Facilitating IS formation is the principal pharmacological action of most T cell-based cancer immunotherapies. However, the dynamics of IS
Can Liu +5 more
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Segregation of receptor-ligand complexes in cell adhesion zones: Phase diagrams and role of thermal membrane roughness [PDF]
, 2010 The adhesion zone of immune cells, the 'immunological synapse', exhibits characteristic domains of receptor-ligand complexes. The domain formation is likely caused by a length difference of the receptor-ligand complexes, and has been investigated in experiments in which T cells adhere to supported membranes with anchored ligands.
arxiv +1 more source
Costimulation: Building an Immunological Synapse
Science, 1999 Immune responses are triggered by activation of the T cell receptor with foreign antigen. Dustin summarizes in his Perspective new evidence that this triggering event is actually the formation of an "immunological synapse," an area of close contact between cells. Recent results ( Viola et al.
Dustin, M, Shaw, A
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Frontiers in Human Neuroscience, 2013 The unconscious mind-brain relationship remains unresolved. From the perspective of neuroscience, neuronal networks including synapses have been dominantly believed to play crucial roles in human mental activities, while glial contribution to mental ...
Takahiro A. Kato +2 more
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The immunological synapse as a pharmacological target
Pharmacological Research, 2018 The development of T cell mediated immunity relies on the assembly of a highly specialized interface between T cell and antigen presenting cell (APC), known as the immunological synapse (IS). IS assembly is triggered when the T cell receptor (TCR) binds to specific peptide antigen presented in association to the major histocompatibility complex (MHC ...
Finetti, Francesca, Baldari, Cosima T
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The combined effect of chemical and electrical synapses in small Hindmarsch-Rose neural networks on synchronisation and on the rate of information [PDF]
Phys. Rev. E, vol. 82, 036203 (2010), 2009 In this work we studied the combined action of chemical and electrical synapses in small networks of Hindmarsh-Rose (HR) neurons on the synchronous behaviour and on the rate of information produced (per time unit) by the networks. We show that if the chemical synapse is excitatory, the larger the chemical synapse strength used the smaller the ...
arxiv +1 more source
The role of gut microbiota‐derived metabolites in neuroinflammation
Neuroprotection, EarlyView.Gut microbiota‐derived metabolites accumulate in the brain, activating or inhibiting microglia and astrocytes, which affects neuroinflammatory progression. The gut microbiota converts the diet into a variety of metabolites, including bile acid, trimethylamine N‑oxide (TMAO), and indole.
Lingjie Mu, Yijie Wang
wiley +1 more source
HIV-1 intersection with CD4 T cell vesicle exocytosis: intercellular communication goes viral
Frontiers in Immunology, 2014 In cells of the immune system the secretion of extracellular vesicles is modulated through cellular activation. In particular, T cell activation is achieved through cell-cell contacts with antigen presenting cells and the consequent formation of a ...
Helena eSoares, Helena eSoares
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Antigen-specific suppression and immunological synapse formation by regulatory T cells require the Mst1 kinase. [PDF]
PLoS ONE, 2013 Although the cell-to-cell contact between CD4(+)Foxp3(+) regulatory T (Treg) and their target cells is important for the suppressor function of Treg cells, the regulation of this process is not well understood.
Takashi Tomiyama +5 more
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Frontiers in Cell and Developmental Biology, 2021 The Jurkat E6.1 clone has been extensively used as a powerful tool for the genetic and biochemical dissection of the TCR signaling pathway. More recently, these cells have been exploited in imaging studies to identify key players in immunological synapse
Chiara Cassioli +13 more
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