Results 81 to 90 of about 30,755 (231)

Costimulation: Building an Immunological Synapse

Science, 1999
Immune responses are triggered by activation of the T cell receptor with foreign antigen. Dustin summarizes in his Perspective new evidence that this triggering event is actually the formation of an "immunological synapse," an area of close contact between cells. Recent results ( Viola et al.
Dustin, M, Shaw, A
openaire   +2 more sources

Antigen-specific suppression and immunological synapse formation by regulatory T cells require the Mst1 kinase. [PDF]

PLoS ONE, 2013
Although the cell-to-cell contact between CD4(+)Foxp3(+) regulatory T (Treg) and their target cells is important for the suppressor function of Treg cells, the regulation of this process is not well understood.
Takashi Tomiyama, Yoshihiro Ueda, Tomoya Katakai, Naoyuki Kondo, Kazuichi Okazaki, Tatsuo Kinashi   +5 more
doaj   +1 more source

Type I and II Interferons Drive Abacavir Hypersensitivity via Treg Suppression and T‐Cell Enhancement in Immunocompetent HLA‐Transgenic Mice

Allergy, EarlyView.
Upregulated HLA‐B*57:01 expression in Tg/KO mice amplifies abacavir‐specific CD8+ T‐cell activation, driven by enhanced antigen presentation. Abacavir treatment induces robust pDC expansion and IFN‐α production, which selectively suppresses memory Treg populations.
SuJin Hwang, Telly Sepahpour, Stephanie Kortchak, Kirthiram Krishnaveni Sivakumar, Spyros Karaiskos, Ngoc Pham, Yura Jang, Montserrat Puig, Michael Norcross   +8 more
wiley   +1 more source

Proteomic and epigenomic markers of sepsis-induced delirium (SID) [PDF]

, 2015
In elderly population sepsis is one of the leading causes of intensive care unit (ICU) admissions in the United States. Sepsis-induced delirium (SID) is the most frequent cause of delirium in ICU (Martin et al., 2010). Together delirium and SID represent
Adonis eSfera, Amy I Price, Carolina eOsorio, Michael eCummings, Roberto eGradini, Roberto eGradini   +5 more
core   +2 more sources

The use of deidentified organ donor testes for research

Andrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source

Adhesion of membranes via receptor-ligand complexes: Domain formation, binding cooperativity, and active processes [PDF]

, 2009
Cell membranes interact via anchored receptor and ligand molecules. Central questions on cell adhesion concern the binding affinity of these membrane-anchored molecules, the mechanisms leading to the receptor-ligand domains observed during adhesion, and ...
Albersdörfer, Alon, Arnold, Asfaw, Auth, Baksh, Bartosz Różycki, Bayas, Bell, Bell, Bershadsky, Bruinsma, Bunnell, Burroughs, Campi, Chen, Chen, Chesla, Choudhuri, Coombs, Davis, Davis, De, Delanoe-Ayari, DeMond, Discher, Dustin, Dustin, Dustin, Dustin, Dustin, Dustin, El Alaoui Faris, Figge, Fournier, Geiger, Girard, Goetz, Gov, Gov, Gov, Grakoui, Gruhn, Heinrich Krobath, Helfrich, Hu, Huang, Ichimura, Irvine, Jeppesen, Kim, Kloboucek, Komura, Krobath, Krogsgaard, Leckband, Lee, Lin, Lin, Lipowsky, Lipowsky, Lorz, Maier, Manneville, Martin, McDonnell, Mesfin Asfaw, Monks, Moore, Moreira, Mossman, Möller, Orsello, Prost, Purbhoo, Purrucker, Qi, Ramaswamy, Raychaudhuri, Reinhard Lipowsky, Reister-Gottfried, Rich, Różycki, Różycki, Różycki, Różycki, Sabra, Sako, Schuck, Schwarz, Schütz, Seifert, Selhuber-Unkel, Shenoy, Smith, Smith, Smith, Takagi, Thomas R. Weikl, Tolentino, Tordeux, Tsourkas, Tsourkas, Varma, Weikl, Weikl, Weikl, Weikl, Weikl, Williams, Winter, Wu, Yokosuka, Yokosuka, Yokosuka, Zhang, Zhu   +116 more
core   +2 more sources

Mast cell synapses and exosomes: membrane contacts for information exchange

Frontiers in Immunology, 2012
In addition to their central role in allergy, mast cells are involved in a wide variety of cellular interactions during homeostasis and disease.
Amanda eCarroll-Portillo, Zurab eSurviladze, Alessandra eCambi, Diane S. Lidke, Bridget S eWilson   +4 more
doaj   +1 more source

Frontline Therapy in Diffuse Large B‐Cell Lymphoma: Evolving Standards, Biological Insights, and Future Directions

European Journal of Haematology, EarlyView.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) remains the most common aggressive lymphoma, representing a biologically heterogeneous disease with diverse clinical behaviors. For more than two decades, R‐CHOP has been the cornerstone of frontline treatment, curing approximately two‐thirds of patients.
Mamdouh Skafi, Santino Caserta, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Fortunato Morabito, Enrica Antonia Martino, Massimo Gentile   +12 more
wiley   +1 more source

Membrane adhesion and domain formation

, 2007
We review theoretical results for the adhesion-induced phase behavior of biomembranes. The focus is on models in which the membranes are represented as discretized elastic sheets with embedded adhesion molecules. We present several mechanism that lead to
Lipowsky, Reinhard, Weikl, Thomas R.
core   +1 more source

Oral Inflammation, Tooth Loss, Risk Factors, and Association with Progression of Alzheimer’s Disease [PDF]

, 2014
Periodontitis is a polymicrobial chronic inflammatory disease of tooth-supporting tissues with bacterial etiology affecting all age groups, becoming chronic in a subgroup of older individuals.
Crean, Stjohn, Harding, Alice, Kesavalu, Lakshmyya, Robinson, Sarita Jane, Simmons, Tal, Singhrao, Simarjit Kaur   +5 more
core   +1 more source