Results 81 to 90 of about 462,461 (237)

The upside of epilepsy: Theories of an evolutionary paradox

Epilepsia Open, EarlyView.
Abstract The persistence of common, heritable conditions, like epilepsy, that are associated with reduced reproductive fitness is an evolutionary paradox. Endogenous analgesic, anti‐depressant, and inflammatory mechanisms able to repair compromised functions can offer advantages in unexpected crises.
Alyssa Ailion, Christoph Helmstaedter, Annamaria Vezzani, Matthias J. Koepp   +3 more
wiley   +1 more source

Effective Membrane Model of the Immunological Synapse [PDF]

Physical Review Letters, 2003
6 pages, 3 figures, submitted for ...
Arup K. Chakraborty, Arup K. Chakraborty, Mehran Kardar, Subhadip Raychaudhuri   +3 more
openaire   +4 more sources

In Vivo Anergized T Cells Form Altered Immunological Synapses In Vitro

American Journal of Transplantation, 2006
T cells contact allogeneic antigen presenting cells (APCs) and assemble, at their contact interface, a molecular platform called the immunological synapse.
E. Zambricki, Tomasz Zal, P. Yachi, Alana A. Shigeoka, J. Sprent, N. R. Gascoigne, Dianne B. McKay   +6 more
semanticscholar   +1 more source

Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic CNS Inflammation

Glia, EarlyView.
ABSTRACT Multiple sclerosis (MS) is the most common non‐infectious inflammatory CNS disease, characterized by progressive neurodegeneration and focal demyelinated lesions. Traditionally considered an autoimmune disease, MS is driven by the immune system's attack on CNS myelin, resulting in cumulative disability.
Volker Siffrin
wiley   +1 more source

Role of astrocyte in neuroinflammation‐induced loss in neuroplasticity and subsequent onset of depression: A systematic review

Neuroprotection, EarlyView.
Mechanistic crosstalk between microglia and astrocytes in major depressive disorder. Abstract Major depressive disorder (MDD) is a complex psychiatric condition increasingly linked to chronic neuroinflammation, particularly in the context of aging, stress, and systemic comorbidities.
Gaurav Singhal, Saurabh Singhal, Bernhard T. Baune   +2 more
wiley   +1 more source

Immunological Synapse: Center of Attention Again [PDF]

Immunity, 2008
The functional role of molecular clustering in the center of the immunological synapse is controversial. In this issue of Immunity, Cemerski et al. (2008) report that the synapse center can serve as a major site of sustained signal transduction.
Salvatore Valitutti, Salvatore Valitutti
openaire   +3 more sources

Durable Interactions of T Cells with T Cell Receptor Stimuli in the Absence of a Stable Immunological Synapse

Cell Reports, 2018
Summary: T cells engage in two modes of interaction with antigen-presenting surfaces: stable synapses and motile kinapses. Although it is surmised that durable interactions of T cells with antigen-presenting cells involve synapses, in situ 3D imaging ...
Viveka Mayya, Edward Judokusumo, Enas Abu Shah, Christopher G. Peel, Willie Neiswanger, David Depoil, David A. Blair, Chris H. Wiggins, Lance C. Kam, Michael L. Dustin   +9 more
doaj  

Mast cell synapses and exosomes: membrane contacts for information exchange

Frontiers in Immunology, 2012
In addition to their central role in allergy, mast cells are involved in a wide variety of cellular interactions during homeostasis and disease.
Amanda eCarroll-Portillo, Zurab eSurviladze, Alessandra eCambi, Diane S. Lidke, Bridget S eWilson   +4 more
doaj   +1 more source

Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu, Kyungdo Kim, Nicholas Asiimwe, Chan Hyun Na   +3 more
wiley   +1 more source

Lipid switches in the immunological synapse

Journal of Biological Chemistry
Adaptive immune responses comprise the activation of T cells by peptide antigens that are presented by proteins of the Major Histocompatibility Complex (MHC) on the surface of an antigen-presenting cell. As a consequence of the T cell receptor interacting productively with a certain peptide-MHC complex, a specialized cell-cell junction known as the ...
Griffiths, Gillian, Brügger, Britta, Freund, Christian   +2 more
openaire   +2 more sources