Recognizing early MRI signs (or their absence) is crucial in diagnosing metachromatic leukodystrophy
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1999-2009, December 2022., 2022 Abstract Objectives Metachromatic leukodystrophy (MLD) has characteristic white matter (WM) changes on brain MRI, which often trigger biochemical and genetic confirmation of the diagnosis. In early or pre‐symptomatic disease stages, these typical MRI changes might be absent, hampering early diagnosis.
Daphne H. Schoenmakers +7 more
wiley +1 more source
Agent-Based Modeling of Host-Pathogen Systems: The Successes and Challenges [PDF]
Information Sciences, Volume 179, Issue 10, 29 April 2009, Pages
1379-1389, 2008 Agent-based models have been employed to describe numerous processes in immunology. Simulations based on these types of models have been used to enhance our understanding of immunology and disease pathology. We review various agent-based models relevant to host-pathogen systems and discuss their contributions to our understanding of biological ...
arxiv +1 more source
Modeling COVID-19 vaccine-induced immunological memory development and its links to antibody level and infectiousness [PDF]
arXiv, 2022 COVID-19 vaccines have proven to be effective against SARS-CoV-2 infection. However, the dynamics of vaccine-induced immunological memory development and neutralizing antibodies generation are not fully understood, limiting vaccine development and vaccination regimen determination. Herein, we constructed a mathematical model to characterize the vaccine-
arxiv
Graduate students’ interest in immunology as a discipline
Cogent Education, 2017 Interest and motivation significantly influence achievement; however, interest in immunology remains to be determined. Using a structured questionnaire, the current study assessed for the first time interest in immunology among biomedical graduate ...
Alexander Kwarteng +5 more
doaj +1 more source
Aktualʹnaâ Infektologiâ, 2016 The paper considers the role of antigenic imprinting phenomena and antibody-dependent enhancement of infection in epidemic, infectious and postvaccinal processes. Based on published experimental data, it is shown that both phenomena are directly related
M.V. Supotnytskyi
doaj +1 more source
Metabolite changes in blood predict the onset of tuberculosis
, 2018 Immunogenetics and cellular immunology of bacterial infectious ...
Boom, W.H. +21 more
core +1 more source
C-type lectins in immunity : recent developments [PDF]
, 2014 Acknowledgements We thank the Wellcome Trust (Grant No. 102705) and Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (Grant No. 97377) for funding.
Brown, Gordon D, Dambuza, Ivy M
core +2 more sources
Augmenting adaptive immunity: progress and challenges in the quantitative engineering and analysis of adaptive immune receptor repertoires [PDF]
Mol. Syst. Des. Eng. (2019), 2019 The adaptive immune system is a natural diagnostic and therapeutic. It recognizes threats earlier than clinical symptoms manifest and neutralizes antigen with exquisite specificity. Recognition specificity and broad reactivity is enabled via adaptive B- and T-cell receptors: the immune receptor repertoire.
arxiv +1 more source
Novel insights into host-fungal pathogen interactions derived from live-cell imaging [PDF]
, 2015 Acknowledgments The authors acknowledge funding from the Wellcome Trust (080088, 086827, 075470 and 099215) including a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology 097377 and FP7-2007–2013 grant agreement HEALTH-F2-2010 ...
A Casadevall +77 more
core +1 more source
To respond or not to respond - a personal perspective of intestinal tolerance [PDF]
, 2018 For many years, the intestine was one of the poor relations of the immunology world, being a realm inhabited mostly by specialists and those interested in unusual phenomena.
A Besredka +142 more
core +1 more source