Results 31 to 40 of about 1,173,119 (240)
Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld +5 morewiley +1 more sourceReciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.Marie Déborah Bancilhon, Bruno Mesminwiley +1 more sourceT-cell recognition is shaped by epitope sequence conservation in the host proteome and microbiome [PDF]
, 2016 Several mechanisms exist to avoid or suppress inflammatory T-cell immune responses that could prove harmful to the host due to targeting self-antigens or commensal microbes.Bancroft, Tara, Bresciani, Anne Gøther, Dillon, Myles B., Greenbaum, Jason, Nielsen, Morten, Paul, Sinu, Peters, Bjoern, Schommer, Nina, Sette, Alessandro +8 morecore +2 more sourcesMulti‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica +10 morewiley +1 more sourceMathematical models for immunology:current state of the art and future research directions [PDF]
, 2016 The advances in genetics and biochemistry that have taken place over the last 10 years led to significant advances in experimental and clinical immunology.A Bauer, A Bellouquid, A Bellouquid, A Carbo, A Chakraborty, A Chakraborty, A Chavali, A Ghaffari, A Hamdache, A Malkin, A Mander, A Moskalensky, A Nag, A Perelson, A Pigozzo, A Prasad, A Smith, A Smith, A Tóth, B Chen, B Cumming, B Goldstein, B Hancioglu, B Kholodenko, B Kidd, B Rivière, B Rouse, B Su, B Thorne, B Zolnik, C Beauchemin, C Bianca, C Bianca, C Bianca, C Bianca, C Davis, C Dool van den, C Gerlach, C Macnamara, C Pommerenke, C Sinclair, D Bandura, D Barua, D Chen, D Choo, D Coombs, D Finlay, D Kirschner, D Laydon, D Liu, D Mallet, D Mathis, D Smith, D Winter, D Wylie, Doreen A. Cantrell, E Ahrens, E Castillo-Montiel, E Hawkins, E Mochan, E Newell, E Numfor, E Pearce, E Pearce, E Rykiel, E Stirk, F Castiglione, F Castiglione, F Crauste, F Fellizi, F Gross, F Pappalardo, F Pappalardo, G An, G Bogle, G Bogle, G Bonizzi, G Huynh, G Lythe, H Caswell, H Knútsdóttir, H Lee, H Miao, H Miao, H Zheng, I Bains, I Baltcheva, I Nahum-Shani, ID Braber, J Beltman, J Currie, J Day, J Dunster, J Faeder, J Flegg, J Flegg, J Gillard, J Heffernan, J Kim, J Köbig, J Linderman, J Mansfield, J Mattes, J Perley, J Reynolds, J Sekar, J Tan, J Wares, Joseph J. Gillard, K Blyuss, K Fujarewicz, K Ganeshan, K García-Martínez, K Janes, K Murphy, K Norris, K Popper, K Saeki, K Smith, K Yoshida, KH Farh, L Balagopalan, L Bayón, L Borghesi, L Canini, L Canini, L DePillis, L Pillis de, L Romani, M Artyomov, M Chaplain, M Fallahi-Sichani, M Figge, M Halling-Brown, M Itik, M Kalos, M Kolev, M Kolev, M Krummel, M Lever, M Mentis, M Nishikori, M Onsum, M Pogson, M Reed, M Sneddon, N Bellomo, N Bellomo, N Burroughs, N Burroughs, N Burroughs, N Cilfone, N Clifone, N Figueroa-Morales, N Kim, N Kronik, N Oreskes, N Strbo, O Dushek, O Serichantalergs, P Ankomah, P Cao, P Francois, P Gannon, P Johnson, P Kim, P Kim, P Kourilsky, P Morel, P Thagard, P Verdijk, Q Yang, R Andersen, R Antia, R Callard, R Callard, R Cheong, R Cheong, R Eftimie, R Eftimie, R Garnier, R Germain, R Germain, R Leander, R Maizels, R Malka, R Medzhitov, R Saenz, R Spreafico, R Stengel, R Williams, R Zinkernagel, Raluca Eftimie, RD Boer, S Adra, S Andrew, S Basak, S Celli, S Dai, S Gadhamsetty, S Gordon, S Henrickson, S Hoops, S Hugues, S Krishna, S Lawley, S Marino, S Marino, S Meraviglia, S Nagaraja, S Otto, S Prokopiou, S Qi, S Tay, S Villar, S Webb, T Lipniacki, T Sun, T Sun, T Tian, TH Lee, U Foryś, U Ledzewicz, U Schnell, V Ganusov, V Kocabas, W Shou, W Singer, Y Chew, Y Kim, Y Kim, Y Louzoun, Y Vodovotz, Y Vodovotz, Y Wang, YF Qi, Z Feng, Z Feng, Z Kabala, Z Shi, Z Yilmaz +240 morecore +3 more sourcesTonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes +17 morewiley +1 more sourceStress-induced nuclear accumulation is dispensable for Hog1-dependent gene expression and virulence in a fungal pathogen [PDF]
, 2017 The authors thank E. Veal for intellectual input. This work was funded by the UK Biotechnology and Biological Research Council [J.Q. BB/K016393/1; A.J.P.B.Brown, Alistair J P, Day, Alison M, Herrero-de-Dios, Carmen M., MacCallum, Donna M, Quinn, Janet +4 morecore +2 more sourcesData‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes
Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo +8 morewiley +1 more sourceDermatology [PDF]
, 2004 Dermatology continues to develop at a steady pace. In the past few years there have been exciting advances in our understanding of skin structure and function in health and disease and progress in genetics, epidemiology, immunology, pharmacology and ...Boffa, Michael J.core +1 more source
