Results 221 to 230 of about 12,077 (249)

Therapeutic targeting of immunometabolism reveals a critical reliance on hexokinase 2 dosage for microglial activation and Alzheimer’s progression

Cell Reports
SUMMARY Neuroinflammation is a prominent feature of Alzheimer’s disease (AD). Activated microglia undergo a reprogramming of cellular metabolism necessary to power their cellular activities during disease.
Juan F. Codocedo, Claudia Mera-Reina, Peter Bor-Chian Lin, Paul B. Fallen, Shweta S. Puntambekar, B. Casali, Nur Jury-Garfe, P. Martínez, Cristian A. Lasagna-Reeves, Gary E. Landreth   +9 more
semanticscholar   +1 more source

Weight Loss‐Associated Remodeling of Adipose Tissue Immunometabolism

Obesity Reviews
Obesity is a multifactorial condition characterized by excessive adiposity and systemic chronic low‐grade inflammation. Recent literature reflects a growing appreciation for the complex interplay between metabolism and the immune system in the ...
P. Basso, A. Schcolnik-Cabrera, Mengyi Zhu, Erin Strachan, Xavier Clemente-Casares, Sue Tsai   +5 more
semanticscholar   +1 more source

Phytochemical alkaloids orchestrate immunometabolism against viral infections

National Science Review
The role of cholesterol metabolism in antiviral immunity has been established, but if and how this cholesterol-mediated immunometabolism can be regulated by specific small molecules is of particular interest in the quest for novel antiviral therapeutics.
Cuiqin Cheng, Yao Wang, Han Wang, Meiqi Zhang, Qi-qi Li, Bing Xu, Lingdong Kong, Xia Liu, Yanli Yu, Yuting He, Yingjie Chu, Zhe Liu, Yuanyuan Qiao, Xinxin Yuan, Xin Jia, Anlong Xu   +15 more
semanticscholar   +1 more source

Immunometabolism: The role of gut‐derived microbial metabolites in optimising immune response during checkpoint inhibitor therapy

Clinical and Translational Medicine
Checkpoint inhibitor therapy is the most common type of immunotherapy used in the clinical setting, however, there are significant obstacles with treatment resistance and cancer progression. Since its introduction, there have been relatively few advances
A. Malczewski, Jermaine I. Coward, N. Ketheesan, S. Navarro   +3 more
semanticscholar   +1 more source

Regulating the proinflammatory response to composite biomaterials by targeting immunometabolism

Bioactive Materials
Composite biomaterials comprising polylactide (PLA) and hydroxyapatite (HA) are applied in bone, cartilage and dental regenerative medicine, where HA confers osteoconductive properties.
Chima V. Maduka, Ashley V. Makela, Anthony Tundo, E. Ural, Katlin B. Stivers, Maxwell M. Kuhnert, M. Alhaj, Ehsanul Hoque Apu, Nureddin Ashammakhi, K. Hankenson, Ramani Narayan, Jennifer H. Elisseeff, C. Contag   +12 more
semanticscholar   +1 more source

Immunometabolism

2023
Michihito Kono, Amir Sharabi, George C. Tsokos   +2 more
openaire   +1 more source

Modulation of Macrophage Immunometabolism: A New Approach to Fight Infections

Frontiers in Immunology, 2022
Wanjun Chen, Thierry Gauthier, Chen Wanjun   +2 more
exaly  

Immunometabolism of Macrophages in Bacterial Infections

Frontiers in Cellular and Infection Microbiology, 2021
Maya Saleh
exaly  

Krebs Cycle Reborn in Macrophage Immunometabolism

Annual Review of Immunology, 2020
Luke O'Neill
exaly  

B cell immunometabolism in health and disease

Nature Immunology
Eleonora Martinis, S. Tonon, Alessandra Colamatteo, A. La Cava, G. Matarese, C. Pucillo   +5 more
semanticscholar   +1 more source