Results 201 to 210 of about 10,784 (232)
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Immunometabolism of infections
Nature Reviews Immunology, 2019Physiological studies of infection biology revealed decades ago that there is an intimate relationship between the immune system and the host metabolic system. These interactions begin soon after pathogen detection and continue to evolve over the course of the infection.
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Immunometabolism the CyTOF way
Immunity, 2021In this issue of Immunity, Levine et al. report a CyTOF-based approach for the analyses of CD8+ T cells metabolic changes at the single-cell level. This approach identified a transition state early in T cell activation that is characterized by high glycolytic and oxidative activity, providing new insight into the metabolic changes that underlie the ...
Liujia, Qian, Tiannan, Guo
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Immunometabolism in Health and Disease
Endocrine, Metabolic & Immune Disorders - Drug Targets, 2022Mehrnoosh, Doroudchi, Kurosh, Kalantar
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An Integrated View of Immunometabolism [PDF]
Cell, 2018 The worldwide obesity epidemic has emerged as a major cause of insulin resistance and Type 2 diabetes. Chronic tissue inflammation is a well-recognized feature of obesity, and the field of immunometabolism has witnessed many advances in recent years. Here, we review the major features of our current understanding with respect to chronic obesity-related
Yun Sok Lee +2 more
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The immunometabolic ecosystem in cancer
Nature Immunology, 2023Our increased understanding of how key metabolic pathways are activated and regulated in malignant cells has identified metabolic vulnerabilities of cancers. Translating this insight to the clinics, however, has proved challenging. Roadblocks limiting efficacy of drugs targeting cancer metabolism may lie in the nature of the metabolic ecosystem of ...
Glenn R. Bantug, Christoph Hess
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Immunometabolism in rheumatoid arthritis [PDF]
Immunological Medicine, 2018 Recent studies have revealed a relationship between cellular metabolism and cell function in immune cells. Cellular metabolism not only provides supplemental ATP, but also supports dynamic changes in cell proliferation and differentiation. For example, T cells exhibit subset-specific metabolic profiles, and require certain types of metabolism for their
Takaichi Okano +2 more
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Immunometabolism, pregnancy, and nutrition
Seminars in Immunopathology, 2017The emerging field of immunometabolism has substantially progressed over the last years and provided pivotal insights into distinct metabolic regulators and reprogramming pathways of immune cell populations in various immunological settings. However, insights into immunometabolic reprogramming in the context of reproduction are still enigmatic.
Kristin, Thiele +2 more
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A guide to interrogating immunometabolism
Nature Reviews Immunology, 2021The metabolic charts memorized in early biochemistry courses, and then later forgotten, have come back to haunt many immunologists with new recognition of the importance of these pathways. Metabolites and the activity of metabolic pathways drive energy production, macromolecule synthesis, intracellular signalling, post-translational modifications and ...
Kelsey Voss +5 more
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Redox regulation of immunometabolism
Nature Reviews Immunology, 2020Metabolic pathways and redox reactions are at the core of life. In the past decade(s), numerous discoveries have shed light on how metabolic pathways determine the cellular fate and function of lymphoid and myeloid cells, giving rise to an area of research referred to as immunometabolism.
Jonathan Muri, Manfred Kopf
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Immunometabolism around the Clock
Trends in Molecular Medicine, 2019Almost every cell has a molecular clock, which controls gene expression on a 24-h cycle, providing circadian rhythmicity. An example of a circadian behaviour common to most organisms is the feeding/fasting cycle, which shapes whole-body metabolism. However, the exact mechanisms by which the clock controls cellular metabolism have only recently become ...
Richard G, Carroll +4 more
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