Results 201 to 210 of about 15,033 (230)
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Immunometabolism and autoimmunity
Current Opinion in Immunology, 2020Over the last few years, immune cell metabolism has become one of the most stimulating areas of investigation in the field of immunology. Compelling evidence has revealed that metabolic pathways are closely associated to cell functions and immune cells adopt defined metabolic programs to sustain their activity and respond to micro-environmental demands.
Galgani M, Bruzzaniti S, Matarese G
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Metabolomics, Lipidomics, and Immunometabolism
2021Metabolomics, lipidomics, and the study of cellular metabolism are gaining increasing interest particularly in the field of immunology, since the activation and effector functions of immune cells are profoundly controlled by changes in cellular metabolic asset.
Carbone F. +8 more
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Tissue-specific macrophage immunometabolism
Current Opinion in Immunology, 2023Macrophages are phagocytic cells distributed across tissues that sustain homeostasis by constantly probing their local environment. Upon perturbations, macrophages rewire their energy metabolism to execute their immune programs. Intensive research in the field of immunometabolism highlights cell-intrinsic immunometabolites such as succinate and ...
Hadar Ben-Arosh, Roi Avraham
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Immunometabolism the CyTOF way
Immunity, 2021In this issue of Immunity, Levine et al. report a CyTOF-based approach for the analyses of CD8+ T cells metabolic changes at the single-cell level. This approach identified a transition state early in T cell activation that is characterized by high glycolytic and oxidative activity, providing new insight into the metabolic changes that underlie the ...
Liujia, Qian, Tiannan, Guo
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Immunometabolism and autoimmunity
Immunology & Cell Biology, 2016A continuous increase in the prevalence of autoimmune diseases is to be expected in the aging societies worldwide. Autoimmune disorders not only cause severe disability and chronic pain, but also lead to considerable socio‐economic costs. Given that the current treatment options are not curative, have substantial side effects and a high percentage of ...
Jenny, Freitag +3 more
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Immunometabolism, pregnancy, and nutrition
Seminars in Immunopathology, 2017The emerging field of immunometabolism has substantially progressed over the last years and provided pivotal insights into distinct metabolic regulators and reprogramming pathways of immune cell populations in various immunological settings. However, insights into immunometabolic reprogramming in the context of reproduction are still enigmatic.
Kristin, Thiele +2 more
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Immunometabolism of infections
Nature Reviews Immunology, 2019Physiological studies of infection biology revealed decades ago that there is an intimate relationship between the immune system and the host metabolic system. These interactions begin soon after pathogen detection and continue to evolve over the course of the infection.
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Immunometabolism around the Clock
Trends in Molecular Medicine, 2019Almost every cell has a molecular clock, which controls gene expression on a 24-h cycle, providing circadian rhythmicity. An example of a circadian behaviour common to most organisms is the feeding/fasting cycle, which shapes whole-body metabolism. However, the exact mechanisms by which the clock controls cellular metabolism have only recently become ...
Richard G, Carroll +4 more
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Cancer immunometabolism: advent, challenges, and perspective
Molecular CancerFor decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism to the center stage of innate and adaptive ...
Qin Dang +14 more
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Immunometabolism in atherosclerotic disorders
Nature Cardiovascular ResearchCardiovascular diseases (CVDs), including atherosclerosis, myocardial infarction and heart failure, are the leading causes of morbidity and mortality worldwide. Emerging evidence suggests a crucial role for immune cell dysfunction and inflammation in the progression of this complex set of diseases. Recent advances demonstrate that immune cells, tightly
Andrew J. Fleetwood +4 more
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