Results 201 to 210 of about 12,077 (249)
Some of the next articles are maybe not open access.
Redox regulation of immunometabolism
Nature Reviews Immunology, 2020Metabolic pathways and redox reactions are at the core of life. In the past decade(s), numerous discoveries have shed light on how metabolic pathways determine the cellular fate and function of lymphoid and myeloid cells, giving rise to an area of research referred to as immunometabolism.
Jonathan Muri, Manfred Kopf
openaire +3 more sources
Editorial overview: Immunometabolism
Current Opinion in Pharmacology, 2021Energy metabolism is a key determinant of the immune response. Classical biochemistry has precisely dissected intracellular metabolic pathways, highlighting how cells adapt to different tasks requiring increasing energy demand. However, until about two decades ago, most immunologists assumed that immune cells were a realm apart that did not comply with
Di Virgilio F., Borges da Silva H.
openaire +2 more sources
A guide to interrogating immunometabolism
Nature Reviews Immunology, 2021The metabolic charts memorized in early biochemistry courses, and then later forgotten, have come back to haunt many immunologists with new recognition of the importance of these pathways. Metabolites and the activity of metabolic pathways drive energy production, macromolecule synthesis, intracellular signalling, post-translational modifications and ...
Kelsey Voss +5 more
openaire +2 more sources
Immunometabolism and oxidative stress: roles and therapeutic strategies in cancer and aging
npj AgingImmunometabolism, encompassing metabolic processes within the immune system, plays a pivotal role in modulating the development, activity, and function of immune cells.
Nan-Jie Zhou +8 more
semanticscholar +1 more source
Immunometabolism, pregnancy, and nutrition
Seminars in Immunopathology, 2017The emerging field of immunometabolism has substantially progressed over the last years and provided pivotal insights into distinct metabolic regulators and reprogramming pathways of immune cell populations in various immunological settings. However, insights into immunometabolic reprogramming in the context of reproduction are still enigmatic.
Kristin, Thiele +2 more
openaire +2 more sources
Immunometabolism in the Aging Heart
Journal of the American Heart AssociationStructural, functional, and molecular‐level changes in the aging heart are influenced by a dynamic interplay between immune signaling and cellular metabolism that is referred to as immunometabolism. This review explores the crosstalk between cellular metabolic pathways including glycolysis, oxidative phosphorylation, fatty acid metabolism, and the ...
Zeb Zacharias +2 more
exaly +4 more sources
Immunometabolism around the Clock
Trends in Molecular Medicine, 2019Almost every cell has a molecular clock, which controls gene expression on a 24-h cycle, providing circadian rhythmicity. An example of a circadian behaviour common to most organisms is the feeding/fasting cycle, which shapes whole-body metabolism. However, the exact mechanisms by which the clock controls cellular metabolism have only recently become ...
Richard G, Carroll +4 more
openaire +2 more sources
The immunometabolic ecosystem in cancer
Nature Immunology, 2023Our increased understanding of how key metabolic pathways are activated and regulated in malignant cells has identified metabolic vulnerabilities of cancers. Translating this insight to the clinics, however, has proved challenging. Roadblocks limiting efficacy of drugs targeting cancer metabolism may lie in the nature of the metabolic ecosystem of ...
Glenn R. Bantug, Christoph Hess
openaire +2 more sources
EBioMedicine
Summary Increasing evidence indicates that immunotherapy is hindered by a hostile tumor microenvironment (TME) featured with deprivation of critical nutrients and pooling of immunosuppressive metabolites.
Jieyu Liu +4 more
semanticscholar +1 more source
Summary Increasing evidence indicates that immunotherapy is hindered by a hostile tumor microenvironment (TME) featured with deprivation of critical nutrients and pooling of immunosuppressive metabolites.
Jieyu Liu +4 more
semanticscholar +1 more source
Immunometabolism in Health and Disease
Endocrine, Metabolic & Immune Disorders - Drug Targets, 2022Mehrnoosh, Doroudchi, Kurosh, Kalantar
openaire +2 more sources