Results 211 to 220 of about 12,077 (249)

Neuroinflammation and immunometabolism in neurodegenerative diseases

Current Opinion in Neurology
Purpose of review Immunometabolism is an emerging field of research investigating the ability of immune cells to modulate their metabolic activity for optimal function. While this has been extensively examined in peripheral immune cells like macrophages,
N. Lonkar, E. Latz, R. McManus
semanticscholar   +1 more source

Hypoxia and immunometabolism in the tumor microenvironment: insights into mechanisms and therapeutic potential.

Cancer Letters
The tumor microenvironment (TME), regulated by both intrinsic oncogenic factors and immune metabolic processes, has become an increasing focus of research in recent years.
Cen Wu, Tianhua Xu, Heyang Zhang, Yile Hu, Jing Jiao, Kun Qiu, J. Gu, Wenya Li, Lei Sun   +8 more
semanticscholar   +1 more source

Immunometabolism in atherosclerotic disorders

Nature Cardiovascular Research
Cardiovascular diseases (CVDs), including atherosclerosis, myocardial infarction and heart failure, are the leading causes of morbidity and mortality worldwide. Emerging evidence suggests a crucial role for immune cell dysfunction and inflammation in the progression of this complex set of diseases. Recent advances demonstrate that immune cells, tightly
Andrew J. Fleetwood, Jonathan Noonan, Nicole La Gruta, Axel Kallies, Andrew J. Murphy   +4 more
openaire   +2 more sources

Fe/Mo‐Based Lipid Peroxidation Nanoamplifier Combined with Adenosine Immunometabolism Regulation to Augment Anti‐Breast Cancer Immunity

Advances in Materials
Immunogenic cell death (ICD)‐mediated immunization strategies have great potential against breast cancer. However, traditional strategies neglect the increase in the immunosuppressive metabolite, adenosine (ADO), during ICD, leading to insufficient ...
Qinyanqiu Xiang, Xue Yang, Zhiqi Zhang, Jie Yang, Yingbo Li, Jiawei Du, Jue Wang, Kai Fan, Jiaxin Yuan, Jianqiong Zhang, Jinbing Xie, Shenghong Ju   +11 more
semanticscholar   +1 more source

Engineering of Sono-Activatable Immunogels for Immunometabolism Disorder Normalization Therapy of Breast Cancer.

Journal of the American Chemical Society
Sonodynamic therapy (SDT) represents a promising approach for localized immunotherapy of solid tumors, yet its clinical translation is limited by therapy stress-induced adaptive immune resistance. Here, we demonstrate that SDT initially elicits antitumor
Yu Guo, Jiaxing Pan, Junjue Wang, Huijuan Zhang, Wenfang Yang, Fangmin Chen, Bowen Yin, Xiran Cai, Wei Tao, Twan Lammers, Yi Lai, Haijun Yu, Xiuli Hu, Z. Xu   +13 more
semanticscholar   +1 more source

Macrophage Immunometabolism in Pulmonary Homeostasis and Chronic Lung Diseases

International Journal on Biological Sciences
Macrophages play a central role in maintaining pulmonary immune homeostasis and responding to injury. In the lung, alveolar macrophages modulate their metabolic profiles to support essential functions such as microbial clearance, inflammation resolution,
Cong Xie, Maimaititusun Yalikun, Zhenhui Ruan, Hang Yu, Xi Huang, Huahe Zhu, Wenglam Choi, Q. Luo, Zhen Gao, Jingcheng Dong   +9 more
semanticscholar   +1 more source

Mitochondrial immunometabolism in sepsis: orchestrating macrophage polarization and dysfunction

European Journal of Medical Research
Sepsis is a life-threatening condition marked by dysregulated immune responses and organ dysfunction, with macrophages playing central roles in both hyperinflammation and immunosuppression.
Ke Yang, Qiang Zhao, Youhan Sun, Li Lin, Xiao Han   +4 more
semanticscholar   +1 more source

Mitochondria and lysosomes in T cell immunometabolism

Trends in immunology
Metabolic reprogramming and signaling are key orchestrators of T cell immunity. Recent studies have illustrated important roles for intracellular organelles, especially mitochondria and lysosomes, in enforcing T cell metabolism and signaling in response ...
Erienne G Norton, Nicole M. Chapman, Hongbo Chi   +2 more
semanticscholar   +1 more source

The Role of Sustained Type I Interferon Secretion in Chronic HIV Pathogenicity: Implications for Viral Persistence, Immune Activation, and Immunometabolism

Viruses
Human immunodeficiency virus (HIV) infection induces chronic immune activation by stimulating both the innate and adaptive immune systems, resulting in persistent inflammation and immune cell exhaustion. Of note, the modulation of cytokine production and
Eman Teer, N. Mukonowenzou, M. Essop
semanticscholar   +1 more source

Immunometabolism: signaling pathways, homeostasis, and therapeutic targets

MedComm
Immunometabolism plays a central role in sustaining immune system functionality and preserving physiological homeostasis within the organism. During the differentiation and activation, immune cells undergo metabolic reprogramming mediated by complex ...
Rongrong Xu, Xiaobo He, Jia Xu, Ganjun Yu, Yanfeng Wu   +4 more
semanticscholar   +1 more source