Results 11 to 20 of about 59,841 (273)

Sepsis: Immunopathology, Immunotherapies, and Future Perspectives

, 2022
© 2022, AVES. All rights reserved.Sepsis is a syndrome that includes physiological, pathological, and biochemical abnormalities resulting from the host immune response to infection. Despite the improved treatment modalities in recent years, the incidence
Taha Tavaci, TAVACI, Taha, Nurullah Akgun, Akgun, Nurullah   +3 more
core   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Features Local Interlacing Status of Elderly Patients with Primary Angle-Closure Glaucoma

Oftalʹmologiâ, 2021
An increased share of the elderly in the structure of modern society, along with other causes and risk factors, is accompanied by the growing the incidence of glaucoma.
A. M. Chukhraev, N. M. Agarkov, K. I. Proschayev, A. N. Ilnitskiy, A. S. Kulabukhov, A. V. Ivanov   +5 more
doaj   +1 more source

Immunopathology of Chronic Bacterial and Viral Diseases Prevalent in Latin America

, 2020
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject.

core   +2 more sources

Experience in the treatment of psoriasis patients using Apremilast, a selective signalling pathway inhibitor

Vestnik Dermatologii i Venerologii, 2019
The article presents a brief description of Аpremilast — the target synthetic anti-inflammatory drug, which is representative of a new class of agents for the treatment of psoriasis and psoriatic arthritis.
N. V. Kungurov, N. V. Zilberberg, M. M. Kokhan, J. V. Keniksfest, E. V. Grishaeva   +4 more
doaj   +1 more source

mTOR signaling mediates ILC3-driven immunopathology [PDF]

, 2021
Innate lymphoid cells (ILCs) have a protective immune function at mucosal tissues but can also contribute to immunopathology. Previous work has shown that the serine/threonine kinase mammalian target of rapamycin complex 1 (mTORC1) is involved in ...
Teufel, Claudia, Horvath, Edit, Lehmann, Frank M., Peter, Annick, Finke, Daniela, Hall, Michael N., Ercan, Caner, Piscuoglio, Salvatore   +7 more
core   +1 more source

Survival and Pulmonary Injury After Neonatal Sepsis: PD1/PDL1's Contributions to Mouse and Human Immunopathology

Frontiers in Immunology, 2021
Morbidity and mortality associated with neonatal sepsis remains a healthcare crisis. PD1−/− neonatal mice endured experimental sepsis, in the form of cecal slurry (CS), and showed improved rates of survival compared to wildtype (WT) counterparts.
Eleanor A. Fallon, Chun-Shiang Chung, Daithi S. Heffernan, Daithi S. Heffernan, Yaping Chen, Monique E. De Paepe, Alfred Ayala   +6 more
doaj   +1 more source

Implication of Interleukin-12/15/18 and Ruxolitinib in the Phenotype, Proliferation, and Polyfunctionality of Human Cytokine-Preactivated Natural Killer Cells

Frontiers in Immunology, 2018
A brief in vitro stimulation of natural killer (NK) cells with interleukin (IL)-12, IL-15, and IL-18 endow them a memory-like behavior, characterized by higher effector responses when they are restimulated after a resting period of time.
Iñigo Terrén, Idoia Mikelez, Idoia Mikelez, Irati Odriozola, Andrea Gredilla, Javier González, Ane Orrantia, Joana Vitallé, Olatz Zenarruzabeitia, Francisco Borrego, Francisco Borrego, Francisco Borrego   +11 more
doaj   +1 more source

Ficolin-1 and ficolin-3 polymorphisms and susceptibility to rheumatoid arthritis

Autoimmunity, 2020
Rheumatoid arthritis (RA) is an autoimmune disease, which compromises the synovial membrane resulting in chronic inflammation. Ficolins are key proteins of the lectin pathway of complement able to recognize pathogen-associated molecular patterns ...
Cristhine Pieczarka, Fabiana Antunes Andrade, Sandra Jeremias Catarino, Kárita Cláudia Freitas Lidani, Lorena Bavia, Regina Tizzot, Thelma Skare, Iara Jose de Messias-Reason   +7 more
doaj   +1 more source

Experimental manipulation of immune-mediated disease and its fitness costs for rodent malaria parasites

BMC Evolutionary Biology, 2008
Background Explaining parasite virulence (harm to the host) represents a major challenge for evolutionary and biomedical scientists alike. Most theoretical models of virulence evolution assume that virulence arises as a direct consequence of host ...
Graham Andrea L, Read Andrew F, Allen Judith E, Chan Brian HK, Long Gráinne H   +4 more
doaj   +1 more source