Immunoporosis: Role of Innate Immune Cells in Osteoporosis [PDF]
Frontiers in Immunology, 2021 Osteoporosis or porous bone disorder is the result of an imbalance in an otherwise highly balanced physiological process known as ‘bone remodeling’. The immune system is intricately involved in bone physiology as well as pathologies.
Arunika Mukhopadhaya, Sanjeev Routh
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Immunoporosis: Role of immune system in the pathophysiology of different types of osteoporosis [PDF]
Frontiers in Endocrinology, 2022 Osteoporosis is a skeletal system disease characterized by low bone mass and altered bone microarchitecture, with an increased risk of fractures. Classical theories hold that osteoporosis is essentially a bone remodeling disorder caused by estrogen ...
Minqi Li, Hongrui Liu, Yajun Cui
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Case Report: Primary hemophagocytic lymphohistiocytosis with a homozygous PRF1 variant: a case suggesting early immunoporosis and an expanded phenotypic spectrum. [PDF]
Frontiers in ImmunologyFamilial HLH is an autosomal recessive condition characterized by mutations in genes responsible for the secretory lysosome-dependent exocytosis pathway.
Eman T. Al-Antary +11 more
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Bacillus coagulans ameliorates inflammatory bone loss in post-menopausal osteoporosis via modulating the “Gut-Immune-Bone” axis [PDF]
Gut MicrobesOsteoporosis is a systemic skeletal disease that leads to lower bone mineral density and intensifies the risk of unexpected fractures. Recently, our group reported that numerical defect in the frequencies of Bregs along with their compromised tendency to
Pradyumna K. Mishra +2 more
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Neutrophil extracellular traps drive osteoporosis via NCF2-dependent signaling: integrated transcriptomics with mechanistic validation [PDF]
Redox ReportBackground Inflammation and immune responses play key roles in osteoporosis (OP) pathogenesis. Osteoimmunology highlights immune dysregulation as a significant contributor to OP, but the specific biological mechanisms linking immune dysfunction to bone ...
Yili Zhang, Zikai Jin, Shuangliu Chen
exaly +4 more sources
Cissus quadrangularis (Hadjod) Inhibits RANKL-Induced Osteoclastogenesis and Augments Bone Health in an Estrogen-Deficient Preclinical Model of Osteoporosis Via Modulating the Host Osteoimmune System [PDF]
Cells, 2023 Osteoporosis is a systemic skeletal disease characterised by low bone mineral density (BMD), degeneration of bone micro-architecture, and impaired bone strength.
Zaffar Azam +8 more
doaj +2 more sources
Bifidobacterium longum Ameliorates Ovariectomy-Induced Bone Loss via Enhancing Anti-Osteoclastogenic and Immunomodulatory Potential of Regulatory B Cells (Bregs) [PDF]
Frontiers in Immunology, 2022 Discoveries in the last few years have emphasized the existence of an enormous breadth of communication between osteo-immune systems. These discoveries fuel novel approaches for the treatment of several bone pathologies including osteoporosis ...
Leena Sapra +11 more
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Bone mineral density and trabecular bone score in adults with primary immunodeficiencies: a cross-sectional study [PDF]
Frontiers in EndocrinologyIntroductionOsteoporosis is increasingly recognized as an immune-mediated condition (“immunoporosis”), yet data on bone health in adults with primary immunodeficiencies (PIDs) remain limited.
Anna Nowakowska-Płaza +7 more
doaj +2 more sources
Immunoporosis: Immunology of Osteoporosis—Role of T Cells [PDF]
Frontiers in Immunology, 2018 The role of immune system in various bone pathologies, such as osteoporosis, osteoarthritis, and rheumatoid arthritis is now well established. This had led to the emergence of a modern field of systems biology called as osteoimmunology, an integrated ...
Rupesh K. Srivastava +3 more
doaj +2 more sources
From Inflammation to Bone Loss: The Multifaceted Role of Neutrophils in Osteoporosis. [PDF]
Int J InflamNeutrophils, the most abundant innate immune cells, have recently emerged as central regulators in the pathogenesis and treatment of osteoporosis. Traditionally viewed as transient inflammatory responders, neutrophils are now recognized as dynamic mediators linking immune dysregulation, bone remodeling, and aging in the context of osteoimmunology. This
Cheng H, Cheng Y, Wang G, Wang D, Liu X.
europepmc +2 more sources