Results 41 to 50 of about 30,806 (226)

Sulfur Mustard-induced Changes in Blood Urea Nitrogen, Uric Acid and Creatinine Levels of Civilian Victims, and Their Correlation with Spirometric Values

Iranian Journal of Public Health, 2018
Background: The aim of this study was assessment of the chronic effects of sulfur mustard (SM) among victims. Methods: In this cohort study, 355 SM-exposed subjects from Sardasht, and 123 controls from Rabat, both from West Azerbaijan Province, Iran ...
Ensieh Sadat MIRSHARIF, Fatemeh HEIDARY, Mohammad Reza VAEZ MAHDAVI, Reza GHAREBAGHI, Shahriar POURFARZAM, Tooba GHAZANFARI   +5 more
doaj  

Dysregulated Functions of Lung Macrophage Populations in COPD

Journal of Immunology Research, 2018
Chronic obstructive pulmonary disease (COPD) is a diverse respiratory disease characterised by bronchiolitis, small airway obstruction, and emphysema.
Theodore S. Kapellos, Kevin Bassler, Anna C. Aschenbrenner, Wataru Fujii, Joachim L. Schultze   +4 more
doaj   +1 more source

Differential immunoregulation in successful oocyte donation pregnancies compared with naturally conceived pregnancies

, 2014
In oocyte donation (OD) pregnancies, there is a higher level of antigenic dissimilarity between mother and fetus compared with naturally conceived (NC) pregnancies.
Claas, Frans H. J., Swings, G.M.J.S., Keur, C. van der, Swings, Godelieve M. J. S., van der Hoorn, Marie-Louise P., van Beelen, Els, Egmond, A. van, Tirado-Gonzalez, I., Karumanchid, S.A., Blois, Sandra M., Hoorn, M.L.P. van der, Scherjon, S.A., Bianchi, Diana W., Tirado-Gonzalez, Irene, Beelen, E. van, Bianchi, D.W., van Egmond, Angela, Blois, S.M., van der Keur, Carin, Karumanchid, S. Ananth, Claas, F.H.J., Scherjon, Sicco A.   +21 more
core   +1 more source

Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields

Advanced Science, EarlyView.
Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng, Evan M. Cale, Amirabbas Maghsoudi, Matthew S. Sutton, Nancy S. Longo, Rebecca A. Gillespie, Lingshu Wang, Ivan Kosik, Sue Chong, Atsuhiro Yasuhara, Tatsiana Bylund, Arne Schön, Prabhanshu Tripathi, Yaroslav Tsybovsky, Haotian Lei, Nicholas C. Morano, Allison B. Lupatkin, Abraham J. Morton, Zabrina C. Lang, Jordan E. Becker, Isabella R. Frascilla, Myungjin Lee, Ning Li, Cuiping Liu, Ryan S. Roark, Chen‐Hsiang Shen, I‐Ting Teng, David J. Van Wazer, Danyi Wang, Lingyuan Wu, Goran Ahlsen, Mike Castro, Haijuan Du, Michael J. Ernandes, Tiansheng Li, Bob C. Lin, Mark K. Louder, Krisha McKee, Jonah S. Merriam, Sijy O'Dell, Li Ou, Sergei Pletnev, David Prikryl, Qi Qiu, Sarah Rubin, Mallika Sastry, Stephen D. Schmidt, Asif Shajahan, Andrea R. Shiakolas, Sanjay Srivatsan, Baoshan Zhang, Qiong Zhou, Mark Connors, Jason G. Gall, Yicheng Guo, Rick K. Huang, Yaoxing Huang, Richard A. Koup, Q. Paula Lei, John R. Mascola, Reda Rawi, Leonid Serebryannyy, Lawrence Shapiro, Zizhang Sheng, David D. Ho, Patrick C. Wilson, Jonathan W. Yewdell, Theodore C. Pierson, Masaru Kanekiyo, Nicole A. Doria‐Rose, Peter D. Kwong, Tongqing Zhou   +71 more
wiley   +1 more source

Tumor-educated-platelets interact with breast cancer-stem-cells via P-selectin-PSGL1 and ensure stemness and metastasis through WNT-β-catenin-VEGF-VEGFR2 intra-cellular signaling: therapeutic modulation by aspirin

Breast Cancer Research
Background Protagonistic role of platelets promote capillary infiltration of tumors for distant metastasis along with immunosurveillance. Despite existing reports highlighting role of platelets in tumorigenesis, its impact on breast cancer stem cells ...
Aishwarya Guha, Jasmine Sultana, Avishek Bhuniya, Mohona Chakravarti, Saurav Bera, Anirban Sarkar, Sukanya Dhar, Pritha Roy Choudhury, Prodipto Das, Juhina Das, Nilanjan Ganguly, Ipsita Guha, Dhrubajyoti Bairagya, Tapasi Das, Neyaz Alam, Indranil Ghosh, Srabanti Hajra, Subhasis Barik, Kalyan Kusum Mukherjee, Rathindranath Baral, Anamika Bose, Saptak Banerjee   +21 more
doaj   +1 more source

Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation

Nature Communications, 2023
Airway epithelial repair, a key process in the recovery from lung injury, requires a metabolic shift from glycolysis to fatty acid oxidation (FAO). Pharmacological FAO promotion enhances epithelial differentiation, suggesting new therapeutic options.
Stefania Crotta, Matteo Villa, Jack Major, Katja Finsterbusch, Miriam Llorian, Peter Carmeliet, Joerg Buescher, Andreas Wack   +7 more
doaj   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

High monocytic MDSC signature predicts multi-drug resistance and cancer relapse in non-Hodgkin lymphoma patients treated with R-CHOP

Frontiers in Immunology
IntroductionNon-Hodgkin Lymphoma (NHL) is a heterogeneous lymphoproliferative malignancy with B cell origin. Combinatorial treatment of rituximab, cyclophsphamide, hydroxydaunorubicin, oncovin, prednisone (R-CHOP) is the standard treatment regimen for ...
Sukanya Dhar, Mohona Chakravarti, Nilanjan Ganguly, Akata Saha, Shayani Dasgupta, Saurav Bera, Anirban Sarkar, Kamalika Roy, Juhina Das, Avishek Bhuniya, Sarbari Ghosh, Madhurima Sarkar, Srabanti Hajra, Saptak Banerjee, Chiranjib Pal, Bhaskar Saha, Kalyan Kusum Mukherjee, Rathindranath Baral, Anamika Bose   +18 more
doaj   +1 more source

CD8+ T-cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types

EBioMedicine, 2015
Understanding natural immunologic control over Human Immunodeficiency Virus (HIV)-1 replication, as occurs in rare long-term nonprogressors/elite controllers (LTNP/EC), should inform the design of efficacious HIV vaccines and immunotherapies.
Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, Mark Connors   +17 more
doaj   +1 more source

High Expression of FAP in Colorectal Cancer Is Associated With Angiogenesis and Immunoregulation Processes. [PDF]

, 2020
Fibroblast activation protein α (FAP) plays an important role in tissue remodeling and helps tumor cells invade surrounding tissue. We sought to investigate FAP as a prognostic molecular marker in colorectal cancer (CRC) using immunohistochemical and ...
Kancherla, Venkatesh, Soysal, Savas D, Taha-Mehlitz, Stephanie, Ng, Charlotte K. Y., Bolli, Martin, Nicolas, Guillaume P, von Flüe, Markus, Terracciano, Luigi M, Eppenberger-Castori, Serenella, Fani, Melpomeni, Terracciano, Luigi M., Soysal, Savas D., Nicolas, Guillaume P., Ercan, Caner, Piscuoglio, Salvatore, Coto-Llerena, Mairene   +15 more
core   +2 more sources