Results 71 to 80 of about 30,806 (226)

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation [PDF]

, 2011
Regulatory T cells (T(reg) cells) are essential for self-tolerance and immune homeostasis. Lack of effector T cell (T(eff) cell) function and gain of suppressive activity by T(reg) cells are dependent on the transcriptional program induced by Foxp3. Here
Schultze, J., Lahl, K., Wickenhauser, C., Samantha L Bailey-Bucktrout, Schoenfeld, Eva, Endl, Elmar, Quast, T., Thabet, Yasser, Bailey-Bucktrout, Samantha L., Classen, Sabine, Sparwasser, Tim, Blazar, Bruce Robert, Famulok, Michael, Beyer, M., Mueller, Roman U., Mayer, C., Beyer, Marc, Jeffrey A Bluestone, Samik Basu, Tatiana Golovina, Percy A Knolle, Debey-Pascher, S., Claudia Wickenhauser, Sommer, D., Katharina Lahl, Bailey-Bucktrout, S., Wolfgang Krebs, Keli L Hippen, Basu, S., Svenja Debey-Pascher, Sadlon, T., Mayer, Guenter, Robert Balderas, Barry, Simon C., Knolle, Percy, Basu, Samik, Eva A Schönfeld, Böttcher, Jan, Gaarz, Andrea, Schönfeld, E., Quast, Thomas, Zhou, Xuyu, Zhou, X., Christian T Mayer, Marc Beyer, Bluestone, J., Elmar Endl, Bernhard Schermer, Debey-Pascher, Svenja, Daniel Sommer, Hippen, K., Andreas Limmer, Knolle, P., Wickenhauser, Claudia, Lahl, Katharina, Mayer, G., Yasser Thabet, Blazar, B., James L Riley, Golovina, T., Limmer, A., Hofmann, A., Kolanus, W., Joachim L Schultze, Tim Sparwasser, Kolanus, Waldemar, Jan Böttcher, Thabet, Y., Sabine Classen, Michael Famulok, Andrea Hofmann, Bruce R Blazar, Xuyu Zhou, Sparwasser, T., Schermer, Bernhard, Balderas, R., Golovina, Tatiana, Waha, Andreas, Sommer, Daniel, Günter Mayer, Waha, A., Müller, R., Timothy Sadlon, Riley, James L, Endl, E., Schultze, Joachim L, Mayer, Christian T., Krebs, Wolfgang, Schermer, B., Waldemar Kolanus, Simon C Barry, Sadlon, Timothy, Andreas Waha, Classen, S., Barry, S., Bluestone, Jeffrey A, Thomas Quast, Krebs, W., Roman-Ulrich Müller, Böttcher, J., Hippen, Keli L., Famulok, M., Balderas, Robert, Riley, J., Limmer, Andreas   +104 more
core   +1 more source

Microbial‐Metabolite Signatures Are Associated With Glucocorticoid Responsiveness in Chronic Rhinosinusitis With Nasal Polyps

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) exhibit heterogeneous responses to oral glucocorticoids (GCs), but the biological basis of this variability remains unclear. Objective To identify gut microbiome‒plasma metabolomic signatures associated with GC responsiveness in CRSwNP patients and to compare their ...
Ying‐Ying Zhang, Xin‐Yu Ding, Mei‐Ping Lu, Yan‐Bing Chen, Ye Yuan, Lin Jiang, Min Zhang, Lei Cheng   +7 more
wiley   +1 more source

The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1+ lymph node macrophages

eLife, 2015
The HIV-1 envelope protein gp120 is both the target of neutralizing antibodies and a major focus of vaccine efforts; however how it is delivered to B cells to elicit an antibody response is unknown.
Chung Park, James Arthos, Claudia Cicala, John H Kehrl   +3 more
doaj   +1 more source

Immunoregulation in cancer-associated cachexia

Background: Cancer-associated cachexia is a multi-organ disorder associated with progressive weight loss due to a variable combination of anorexia, systemic inflammation and excessive energy wasting.
Zhou Liu, Qi Wu, Yu-e Liu, Bei Li, Ping Wang   +4 more
core   +1 more source

DS_10.1177_0022034518759302 – Supplemental material for RANKL Triggers Treg-Mediated Immunoregulation in Inflammatory Osteolysis

, 2018
Supplemental material, DS_10.1177_0022034518759302 for RANKL Triggers Treg-Mediated Immunoregulation in Inflammatory Osteolysis by C.F. Francisconi, A.E. Vieira, M.C.S. Azevedo, A.P. Tabanez, A.C. Fonseca, A.P.F. Trombone, A. Letra, R.M.
C.F. Francisconi (5324123), A. Letra (5324102), A.P.F. Trombone (5324099), S.R. Little (5324117), A.P. Tabanez (5324105), R.M. Silva (5324120), G.P. Garlet (5324126), A.C. Fonseca (5324108), C.S. Sfeir (5324114), A.E. Vieira (5324096), M.C.S. Azevedo (5324111)   +10 more
core   +1 more source

Reframing the Gut–Brain Axis: The Gut Wall as a Neural Immune Interface in Multiple Sclerosis and Autoimmune Neurological Diseases

Annals of Neurology, EarlyView.
Gut wall physiology in multiple sclerosis (MS) and autoimmune neurologic diseases remains underexplored but may span gut barrier dysfunction, enteric glial targeting, mucosal immune dysregulation, and autoimmune targets within the enteric nervous system (ENS).
Federico Montini, Sean J. Pittock, Laura Cacciaguerra, Howard L. Weiner, Luke A. Schwerdtfeger   +4 more
wiley   +1 more source

P1255: TUMOR-ASSOCIATED MONOCYTIC MYELOID DERIVED SUPPRESSOR CELLS IS A POTENTIAL PROGNOSTIC BIOMARKER, PROMOTING MULTI-DRUG RESISTANCE IN NHL PATIENTS BY MODULATING IL-6/IL-10/IL-1Β AXIS

HemaSphere, 2022
S. Dhar, M. Chakravarti, S. Bera, N. Ganguly, S. Dasgupta, A. Sarkar, A. Saha, S. Banerjee, B. Saha, R. Baral, K. K. Mukherjee, A. Bose   +11 more
doaj   +1 more source

NFAT primes the human RORC locus for RORγt expression in CD4+ T cells

Nature Communications, 2019
The master transcription factor RORγt, encoded by the RORC gene, controls the polarization of CD4+ T cells expressing interleukin-17 (Th17). Here the authors describe several regulatory elements at the RORC locus that are recognized by NFAT and NFkB to ...
Hanane Yahia-Cherbal, Magda Rybczynska, Domenica Lovecchio, Tharshana Stephen, Chloé Lescale, Katarzyna Placek, Jérome Larghero, Lars Rogge, Elisabetta Bianchi   +8 more
doaj   +1 more source

ANK1 and EPB41 Variants and The Risk of Glucocorticoid‐Induced Osteonecrosis

Arthritis &Rheumatology, EarlyView.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen, Xianmin Zhu, Zhongzhong Chen, Wei Chen, Hussam Alkaissi, Zeng Zhang, Yun Gao, Junhui Yin, Xiangtian Yu, Qiong Fu, Youshui Gao, Zhenzhong Zhu, Qianying Cai, Pengwei Zhang, Weibin Chen, Xin Zhao, Xiaojin Wu, Karel Pacak, Dongxu Jin, Chunde Bao, Zhengping Zhuang, Changqing Zhang   +21 more
wiley   +1 more source

Deep Immunophenotyping Reveals Distinct Immune Signatures in Axial Spondyloarthritis and Psoriatic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are overlapping yet distinct conditions within the SpA spectrum. As divergent immunophenotypes may influence disease course and therapeutic response, we compared immune cell subsets, cytokine profiles, and inflammatory mediators.
Natalie Frede, Nils Craig‐Müller, Silke Kohrt, Marei‐Theresa Bott, Ulrich Salzer, Ana Cecilia Venhoff, Jens Thiel, Julia Frede, Reinhard E. Voll, Marta Rizzi, Raquel Lorenzetti, Nils Venhoff   +11 more
wiley   +1 more source