Results 91 to 100 of about 353,556 (317)

3D Microtumors Representing Ovarian Cancer Minimal Residual Disease Respond to the Fatty Acid Oxidation Inhibitor Perhexiline

Advanced Healthcare Materials, EarlyView.
Minimal residual disease (MRD) leads to cancer relapse and poor survival in ovarian cancer. The lack of representative 3D models limits therapy development. The microfluidics‐based high throughput 3D microtumor platform described here generates clinically‐relevant MRD models. The 3D microtumors recapitulate the molecular signatures of MRD from patients.
Xingyun Yang, Mara Artibani, Yongcheng Jin, Aneesh Aggarwal, Yujia Zhang, Sandra Muñoz‐Galvan, Ellina Mikhailova, Lena Rai, Nobina Mukherjee, Ravinash Krishna Kumar, Ashwag Albukhari, Shaohua Ma, Linna Zhou, Ahmed Ashour Ahmed, Hagan Bayley   +14 more
wiley   +1 more source

Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia

New England Journal of Medicine, 2017
BACKGROUND Acquired aplastic anemia results from immune‐mediated destruction of bone marrow. Immunosuppressive therapies are effective, but reduced numbers of residual stem cells may limit their efficacy.
D. Townsley, P. Scheinberg, T. Winkler, R. Desmond, B. Dumitriu, O. Rios, B. Weinstein, Janet Valdez, J. Lotter, Xingmin Feng, M. Desierto, Harshraj Leuva, M. Bevans, Colin O. Wu, A. Larochelle, K. Calvo, C. Dunbar, N. Young   +17 more
semanticscholar   +1 more source

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

T cell response against SARS-CoV-2 persists after one year in patients surviving severe COVID-19

EBioMedicine, 2022
Summary: Background: In critically ill COVID-19 patients, the initial response to SARS-CoV-2 infection is characterized by major immune dysfunctions.
Fabienne Venet, Morgane Gossez, Frank Bidar, Maxime Bodinier, Rémy Coudereau, Anne-Claire Lukaszewicz, Claire Tardiveau, Karen Brengel-Pesce, Valérie Cheynet, Marie-Angélique Cazalis, Rémi Pescarmona, Lorna Garnier, Marine Ortillon, Marielle Buisson, Maude Bouscambert-Duchamp, Florence Morfin-Sherpa, Jean-Sébastien Casalegno, Filippo Conti, Thomas Rimmelé, Laurent Argaud, Martin Cour, Mitra Saadatian-Elahi, Laetitia Henaff, Philippe Vanhems, Guillaume Monneret   +24 more
doaj  

Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy

Journal of Immunotherapy for Cancer, 2018
BackgroundCorticosteroids are routinely utilized to alleviate edema in patients with intracranial lesions and are first-line agents to combat immune-related adverse events (irAEs) that arise with immune checkpoint blockade treatment.
Amber J. Giles, Marsha-Kay N. D. Hutchinson, H. Sonnemann, Jinkyu Jung, P. Fecci, Nivedita M. Ratnam, Wei Zhang, Hua Song, R. Bailey, Dionne L Davis, Caitlin M. Reid, Deric M. Park, M. Gilbert   +12 more
semanticscholar   +1 more source

Managing COVID‐19 in Renal Transplant Recipients: A Review of Recent Literature and Case Supporting Corticosteroid‐sparing Immunosuppression

Pharmacotherapy, 2020
Novel coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome virus (SARS‐CoV‐2) has become a global health care crisis. The Centers for Disease Control and Prevention (CDC) lists immunocompromised patients, including those ...
Kristen M. Johnson, Julie J. Belfer, Gina R Peterson, Mark R. Boelkins, Lisa E. Dumkow   +4 more
semanticscholar   +1 more source

Bioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss

Advanced Healthcare Materials, EarlyView.
Volumetric muscle loss (VML) due to trauma or surgery, often leads to physical impairments. Traditional treatments rely on autologous flaps, limited by muscle availability often leading to donor site morbidity. This study presents multimodal bioprinting as an innovative approach for fabricating vascularized muscle flaps with 3D‐printed macrovessels ...
Eliana O. Fischer, Anna Tsukerman, Majd Machour, Margarita Shuhmaher, Asaf Silverstein, Maya Yaakov, Orit Bar‐Am, Lior Debbi, Shulamit Levenberg   +8 more
wiley   +1 more source

Scale-free dynamics of somatic adaptability in immune system [PDF]

arXiv, 2009
The long-time dynamics of somatic adaptability in immune system is simulated by a simple physical model. The immune system described by the model exhibits a scale free behavior as is observed in living systems. The balance between the positive and negative feedbacks of the model leads to a robust immune system where the positive one corresponds to the ...
arxiv  

A nanovaccine for antigen self-presentation and immunosuppression reversal as a personalized cancer immunotherapy strategy

Nature Nanotechnology, 2022
Chao Liu, Xue Liu, Xinchu Xiang, Xin Pang, Siyuan Chen, Yunming Zhang, En Ren, Lili Zhang, Xuan Liu, Peng Lv, Xiaoyong Wang, Wen-xin Luo, N. Xia, Xiaoyuan Chen, Gang Liu   +14 more
semanticscholar   +1 more source

Inorganic Nanomaterials Meet the Immune System: An Intricate Balance

Advanced Healthcare Materials, EarlyView.
Metal nanomaterials influence the immune responses, such as cytokine production and T‐cell activity. Unintended immune modulation can have significant consequences while its fine‐tuning may transform the oncology care. Within this review, a critical analysis is offered regarding the nano/immune‐interaction and suggests the future research directions to
Gloria Pizzoli, Marco Gargaro, Giuliana Drava, Valerio Voliani   +3 more
wiley   +1 more source