Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury
This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng +10 more
wiley +1 more source
Cerebral Abscess Masquerading as Tuberculoma in a Post-Renal Transplant Chronic Kidney Disease Patient: A Diagnostic and Therapeutic Challenge. [PDF]
Abrar S, Khalil I, Hossain MI, Promi SA.
europepmc +1 more source
Cell migration, chimerism, and graft acceptance: with particular reference to the liver [PDF]
Demetris, AJ +4 more
core
Endogenous retrovirus-encoded Syncytin-2 contributes to exosome-mediated immunosuppression of T cells† [PDF]
Adjimon Gatien Lokossou +12 more
openalex +1 more source
Immunotherapy fails in head and neck squamous cell carcinoma (HNSCC) due to terminally exhausted T (Texterm) cells. Tumor‐derived PD‐L1+ extracellular vesicles promote CD8‐Texterm cells differentiation by upregulating BATF. Stromal Texterm density serves as a potent biomarker for predicting immunotherapy resistance, highlighting a novel EV‐mediated ...
Ruihua Fang +15 more
wiley +1 more source
Fig. S15 from Mesenchymal Stem Cells and Fibroblasts Contribute to Microvascular Proliferation in Glioblastoma and are Correlated with Immunosuppression and Poor Outcome [PDF]
Candice C. Poon +19 more
openalex +1 more source
Suppressor of Cytokine Signaling 1 (SOCS1) and SOCS3 Are Stimulated within the Eye during Experimental Murine Cytomegalovirus Retinitis in Mice with Retrovirus-Induced Immunosuppression [PDF]
Hsin Chien +2 more
openalex +1 more source
Integrating spatial transcriptomics and single‐cell RNA sequencing, this study identifies a novel subpopulation of SLPI⁺ AT2‐like cells at the invasive margin of lung adenocarcinoma (LUAD). These cells, through stromal crosstalk and Wnt pathway activation, promote tumor stemness and invasion.
Zhoufeng Wang +13 more
wiley +1 more source
Clinical outcomes of giant coronary aneurysms in South Asian children with Kawasaki disease. [PDF]
Abhinav K +5 more
europepmc +1 more source

