Results 31 to 40 of about 392,479 (342)

Understanding sepsis-induced immunosuppression and organ dysfunctions: from immunosuppression to immunotherapy

Exploration of Immunology, 2022
Sepsis is a life-threatening condition caused by dysregulated host immune response to infection, leading to persistent inflammation followed by immunosuppression.
Dablu Lal Gupta, Tejprakash Sinha, Richa Pathak, Sanjeev Bhoi, D. N. Rao   +4 more
doaj   +1 more source

Consensus recommendations for use of maintenance immunosuppression in solid organ transplantation: Endorsed by the American College of Clinical Pharmacy, American Society of Transplantation, and the International Society for Heart and Lung Transplantation

Pharmacotherapy, 2022
Advances in maintenance immunosuppression over the past three decades have improved solid organ transplantation outcomes dramatically. Uninterrupted access to immunosuppression is paramount to minimize rejection and maintain allograft and patient ...
J. Nelson, N. Alvey, L. Bowman, Jamie Schulte, M. Segovia, J. McDermott, H. Te, N. Kapila, D. Levine, R. Gottlieb, J. Oberholzer, M. Campara   +11 more
semanticscholar   +1 more source

Endogenous Retroviruses Transcriptional Modulation After Severe Infection, Trauma and Burn

Frontiers in Immunology, 2019
Although human endogenous retroviruses (HERVs) expression is a growing subject of interest, no study focused before on specific endogenous retroviruses loci activation in severely injured patients.
Olivier Tabone, Marine Mommert, Marine Mommert, Camille Jourdan, Elisabeth Cerrato, Matthieu Legrand, Alain Lepape, Bernard Allaouchiche, Bernard Allaouchiche, Thomas Rimmelé, Alexandre Pachot, Guillaume Monneret, Guillaume Monneret, Fabienne Venet, Fabienne Venet, François Mallet, François Mallet, Julien Textoris, Julien Textoris   +18 more
doaj   +1 more source

Effect of Maintaining Immunosuppression After Kidney Allograft Failure on Mortality and Retransplantation

Transplantation Direct, 2023
Background. Few studies have addressed immunosuppression management after allograft failure (AF). Immunosuppression withdrawal to minimize complications must be balanced with the risk of sensitization and potentially reduced retransplantation.
Suryanarayanan Balakrishnan, MD, Byron Smith, PhD, MS, Andrew Bentall, MD, Aleksandra Kukla, MD, Massini Merzkani, MD, Mark Stegall, MD, Carrie Schinstock, MD   +6 more
doaj   +1 more source

Immunosuppressive Medications [PDF]

Clinical Journal of the American Society of Nephrology, 2016
Immunosuppressive agents are commonly used in the nephrologist's practice in the treatment of autoimmune and immune-mediated diseases and transplantation, and they are investigational in the treatment of AKI and ESRD. Drug development has been rapid over the past decades as mechanisms of the immune response have been better defined both by serendipity (
openaire   +2 more sources

The Mechanism of Mori Folium and Eucommiae Cortex against Cyclophosphamide-Induced Immunosuppression Integrating Network Pharmacology, Molecular Docking, Molecular Dynamics Simulations, and Experimental Validation

Metabolites, 2023
It has been reported that Mori Folium (MF) and Eucommiae Cortex (EC) exhibit pharmacological effects in the treatment of immunosuppression. However, the mechanism of MF and EC against immunosuppression remains unclear.
Jinde Liu, Qiao Rong, Chunxiao Zhang, Ali Tariq, Lin Li, Yongning Wu, Feifei Sun   +6 more
doaj   +1 more source

T cell response against SARS-CoV-2 persists after one year in patients surviving severe COVID-19

EBioMedicine, 2022
Summary: Background: In critically ill COVID-19 patients, the initial response to SARS-CoV-2 infection is characterized by major immune dysfunctions.
Fabienne Venet, Morgane Gossez, Frank Bidar, Maxime Bodinier, Rémy Coudereau, Anne-Claire Lukaszewicz, Claire Tardiveau, Karen Brengel-Pesce, Valérie Cheynet, Marie-Angélique Cazalis, Rémi Pescarmona, Lorna Garnier, Marine Ortillon, Marielle Buisson, Maude Bouscambert-Duchamp, Florence Morfin-Sherpa, Jean-Sébastien Casalegno, Filippo Conti, Thomas Rimmelé, Laurent Argaud, Martin Cour, Mitra Saadatian-Elahi, Laetitia Henaff, Philippe Vanhems, Guillaume Monneret   +24 more
doaj   +1 more source

Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome

Critical Care, 2021
Background Since the onset of the pandemic, only few studies focused on longitudinal immune monitoring in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS) whereas their hospital stay may last for several weeks ...
Fabienne Venet, Martin Cour, Thomas Rimmelé, Sebastien Viel, Hodane Yonis, Remy Coudereau, Camille Amaz, Paul Abraham, Céline Monard, Jean-Sebastien Casalegno, Karen Brengel-Pesce, Anne-Claire Lukaszewicz, Laurent Argaud, Guillaume Monneret, the RICO study group   +14 more
doaj   +1 more source

Prevalence of Immunosuppression Among US Adults.

Journal of the American Medical Association (JAMA)
This analysis presents population prevalence estimates of immunosuppression among US adults using data from the 2021 National Health Interview Survey.
Melissa L Martinson, J. Lapham
semanticscholar   +1 more source

The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment

Frontiers in Immunology, 2019
Cancer-associated fibroblasts (CAFs) are prominent components of the microenvironment in most types of solid tumors, and were shown to facilitate cancer progression by supporting tumor cell growth, extracellular matrix remodeling, promoting angiogenesis,
Lea Monteran, Neta Erez
semanticscholar   +1 more source