Results 61 to 70 of about 213,546 (300)

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Low-dose cyclosporine therapy in triple-drug immunosuppression for heart transplant recipients

, 1994
The toxicity of long-term immunosuppressive therapy has become a major concern in long-term follow-up of heart transplant recipients. In this respect the quality of renal function is undoubtedly linked to cyclosporin A (CsA) drug levels.
Demertzis, S, Johannes M. Albes, Hans-Georg Borst, Hausen, B, Albes, J M, Bernard Hausen, Hans-Joachim Schäfers, Rohde, R, Roland Rohde, Schäfers, H J, Stefanos Demertzis, Borst, H G   +11 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Multiple Myeloma : an update on disease biology and therapy [PDF]

, 2004
Multiple myeloma is a malignancy of immunoglobulin producing plasma cells. Clinical features include bone pain due to lytic bone lesions or pathological fractures, anemia, symptomatic hypercalcemia, renal insufficiency, recurrent infections and ...
Dingli, David, Cook, Rachel J.
core  

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Autoimmune hepatitis: current concepts in epidemiology, diagnosis, and management [PDF]

Kosin Medical Journal
Autoimmune hepatitis is a rare immune-mediated liver disease that can progress to cirrhosis and liver failure. Its global incidence and prevalence are increasing, with a marked female predominance and substantial regional variation.
Brian J. Wentworth, Kwang Il Seo
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Modern immunosuppression

, 2023
\ua9 2023. Organ transplantation provides both life-saving and life-enhancing function for patients suffering from end-stage organ failure. Transplantation has only been possible due to the advances in immunosuppression.
Wilson C, Figueiredo RS, Mahendran B
core  

‐19 patients with immunosuppression

, 2021
In the absence of effective countermeasures, human convalescent plasma has been widely used to treat severe acute respiratory syndrome coronavirus 2, the causative agent of novel coronavirus disease 19 (COVID-19), including among patients with innate or ...
Senefeld, Jonathon W, Pirofski, Liise-Anne, Bruce C. Bostrom, Wright, R Scott, Wayne T. Nicholson, Thompson, Michael A, Hartman, William R, Katherine A. Senese, Liise‐anne Pirofski, Ford, Shane K, R. Scott Wright, Wiggins, Chad C, Bruno, Katelyn A, Jonathon W. Senefeld, William R. Hartman, Carter, Rickey E, Patrick W. Johnson, Rickey E. Carter, Fairweather, De Lisa, Johnson, Patrick W, Paneth, Nigel S, Klassen, Stephen A, Bostrom, Bruce C, Shane K. Ford, Arturo Casadevall, Jeffrey P. Henderson, Chad C. Wiggins, Baker, Sarah E, Casadevall, Arturo, Joyner, Michael J, Michael A. Thompson, Michael J. Joyner, Katelyn A. Bruno, De Lisa Fairweather, Nigel S. Paneth, Senese, Katherine A, Stephen A. Klassen, Sarah E. Baker, Nicholson, Wayne T, Henderson, Jeffrey P   +39 more
core   +1 more source