Results 41 to 50 of about 215,011 (302)

Helminths and immunological tolerance [PDF]

, 2014
Current immunosuppression regimens for solid-organ transplantation have shown disappointing efficacy in the prevention of chronic allograft rejection and carry unacceptable risks including toxicity, neoplasia, and life-threatening infection.
McSorley, Henry J., Maizels, Rick M., Maizels, Rick M, Johnston, Chris J C, Wigmore, Stephen J, Johnston, Chris J.C., Wigmore, Stephen J., Anderton, Stephen M, McSorley, Henry J, Anderton, Stephen M., Johnston, Chris J. C., McSorley, Henry J.; id_orcid   +11 more
core   +1 more source

The Role of Immunosuppression for Recurrent Cholangiocellular Carcinoma after Liver Transplantation [PDF]

, 2022
SIMPLE SUMMARY: Oncological follow-up after liver transplantation for cholangiocellular carcinoma must consider the risk of recurrence. Immunosuppressive medication with so-called mTOR inhibitors seems to have a tumor-suppressive effect, as improved ...
Öllinger, Robert, Safak Gül-Klein, Deniz Uluk, Moritz Schmelzle, Schmelzle, Moritz, Schöning, Wenzel, Johann Pratschke, Georg Lurje, Ramin Raul Ossami Saidy, Uluk, Deniz, Wenzel Schöning, Jonas, Sven, Pelzer, Uwe, Eurich, Dennis, Lurje, Georg, Sven Jonas, Tacke, Frank, Pratschke, Johann, Ossami Saidy, Ramin Raul, Schmitz, Paulina, Frank Tacke, Gül-Klein, Safak, Paulina Schmitz, Robert Öllinger, Uwe Pelzer, Dennis Eurich   +25 more
core   +1 more source

Successful treatment with tofacitinib for anti-melanoma differentiation-associated gene 5 antibody-positive juvenile dermatomyositis: case reports and review of the literature

Immunological Medicine
Although the clinical efficacy of tofacitinib has been reported in adult patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive (Ab+) dermatomyositis, data on its use in refractory juvenile dermatomyositis (JDM) are scarce.
Susumu Yamazaki, Masaki Shimizu, Ayane Yakabe, Eisuke Inage, Keisuke Jimbo, Mitsuyoshi Suzuki, Futaba Miyaoka, Shuya Kaneko, Hitoshi Irabu, Asami Shimbo, Yoshiyuki Ohtomo, Masaaki Mori, Tomohiro Morio, Toshiaki Shimizu   +13 more
doaj   +1 more source

Analysis of early use of everolimus with low-dose calcineurin inhibitors in kidney transplant recipient

Вестник трансплантологии и искусственных органов, 2019
Aim: to evaluate the efficacy and safety of early use of everolimus in combination with a reduced dose of calcineurin inhibitors (CNI) after kidney transplantation and define approaches to the selection and management of patients on everolimus-based ...
I. G. Kim, N. A. Tomilina, I. V. Ostrovskaya, I. A. Skryabina, N. D. Fedorova   +4 more
doaj   +1 more source

Development and validation of multivariable prediction models of serological response to SARS-CoV-2 vaccination in kidney transplant recipients

Frontiers in Immunology, 2022
Repeated vaccination against SARS-CoV-2 increases serological response in kidney transplant recipients (KTR) with high interindividual variability. No decision support tool exists to predict SARS-CoV-2 vaccination response to third or fourth vaccination ...
Bilgin Osmanodja, Johannes Stegbauer, Marta Kantauskaite, Lars Christian Rump, Andreas Heinzel, Roman Reindl-Schwaighofer, Rainer Oberbauer, Ilies Benotmane, Sophie Caillard, Christophe Masset, Clarisse Kerleau, Gilles Blancho, Klemens Budde, Fritz Grunow, Michael Mikhailov, Eva Schrezenmeier, Eva Schrezenmeier, Simon Ronicke   +17 more
doaj   +1 more source

Cancer risks in rheumatoid arthritis patients who received immunosuppressive therapies: Will immunosuppressants work?

Frontiers in Immunology, 2022
BackgroundExploring the cancer risks of rheumatoid arthritis (RA) patients with disease-modifying anti-rheumatic drugs (DMARDs) can help detect, evaluate, and treat malignancies at an early stage for these patients.
Yuzhuo Zhang, Jiangpeng Lin, Zhixuan You, Hengjia Tu, Peng He, Jiarong Li, Rui Gao, Ziyu Liu, Zhiyuan Xi, Zekun Li, Yi Lu, Yi Lu, Qiyuan Hu, Chenhui Li, Fan Ge, Fan Ge, Zhenyu Huo, Zhenyu Huo, Guibin Qiao   +18 more
doaj   +1 more source

Validation of target genes involved in myeloid immunosuppression for the generation of novel RNA-loaded nanosystems to enhance the efficacy of immunotherapy in Glioblastoma [PDF]

, 2022
reservedGlioblastoma, or grade IV glioma, is the most aggressive form of glioma and it has high invasiveness. The standard care of treatment consists of an initial surgical resection, followed by radiation therapy and Temozolomide chemotherapy.
ZAPPITELLI, TERESA
core  

Clinical valuables related to resolution of complete or advanced atrioventricular block after steroid therapy in patients with cardiac sarcoidosis

Journal of Arrhythmia, 2021
Background Prediction of atrioventricular block (AVB) resolution after steroid therapy in patients with cardiac sarcoidosis (CS) is difficult. Methods We identified 24 patients with CS and complete or advanced AVB receiving steroid therapy.
Takeru Nabeta, Masahiko Hara, Takashi Naruke, Kenji Maemura, Takumi Oki, Mayu Yazaki, Teppei Fujita, Yuki Ikeda, Shunsuke Ishii, Toshimi Koitabashi, Junya Ako   +10 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

From immunosuppression to tolerance [PDF]

, 2015
SummaryThe past three decades have seen liver transplantation becoming a major therapeutic approach in the management of end-stage liver diseases. This is due to the dramatic improvement in survival after liver transplantation as a consequence of the ...
Samuel, Didier, Sanchez-Fueyo, Alberto; id_orcid, Adams, David H., Alberto Sanchez-Fueyo, Sanchez-Fueyo, Alberto, Adams, David H, David H. Adams, Didier Samuel   +7 more
core   +1 more source