Results 21 to 30 of about 215,011 (302)

A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma [PDF]

open access: yes, 2010
Background: The potential anti-cancer effects of mammalian target of rapamycin (mTOR) inhibitors are being intensively studied. To date, however, few randomised clinical trials (RCT) have been performed to demonstrate anti-neoplastic effects in the pure ...
Pinna, Antonio D.   +392 more
core   +2 more sources

Co Treatment With Biologic Agents and Immunotherapy in the Setting of irAEs of Difficult Management

open access: yesFrontiers in Medicine, 2022
In recent years, immunotherapy has become an important pillar of cancer treatment, with high response rates regardless of tumor histology or baseline mutations, sometime in patients without any alternative of treatment.
Virginia Robles-Alonso   +3 more
doaj   +1 more source

Neo-Adjuvant Chemotherapy Reduces, and Surgery Increases Immunosuppression in First-Line Treatment for Ovarian Cancer [PDF]

open access: yes, 2021
UNLABELLED: In monotherapy, immunotherapy has a poor success rate in ovarian cancer. Upgrading to a successful combinatorial immunotherapy treatment implies knowledge of the immune changes that are induced by chemotherapy and surgery.
Jolien Ceusters   +24 more
core   +1 more source

FIRST EXPERIENCE OF APPLICATION OF ASSIST CIRCULATION DEVICE USING BIVENTRICULAR TYPE «EXCOR»

open access: yesВестник хирургии имени И.И. Грекова, 2018
The frequency of use of assist blood device as the «bridge» to the heart transplantation increased in last years. An assessment of results of first 7 implantations of assist circulation device using biventricular type «Excor» was made.
M. L. Gordeev   +12 more
doaj   +1 more source

Immunosuppressive Therapy in Myocarditis

open access: yesCirculation Journal, 2014
Although there is general agreement on the favorable effect of immunosuppression in eosinophilic, granulomatous, giant-cell myocarditis and in lymphocytic myocarditis associated with connective tissue disorders and with rejection of a transplanted heart, its therapeutic role in lymphocytic inflammatory cardiomyopathy (ICM) is still debated.
FRUSTACI, ANDREA, CHIMENTI, CRISTINA
openaire   +4 more sources

Mesenchymal stem cell-mediated T cell immunosuppression [PDF]

open access: yes, 2017
Besides being a pool forstromal cells and connective tissues, the mesenchymal stem cells (MSCs) as well exert a potent immunosuppression against almost all types of immune cells, particularly T cells.
Al-Graittee, Satar Jabbar Rahi   +2 more
core   +1 more source

Case Report: A Case Series of Immunobiological Therapy (Anti-TNF-α) for Patients With Erythema Nodosum Leprosum

open access: yesFrontiers in Medicine, 2022
Patients with leprosy may experience a chronic and severe type II leprosy reaction (ENL) erythema nodosum leprosum that may not respond to thalidomide and systemic immunosuppressants or may even cause serious adverse events. We here present four patients
Ana Flávia Moura Mendes   +4 more
doaj   +1 more source

Combinatorial functions of two chimeric antibodies directed to human CD4 and one directed to the a-chain of the human interleukin-2 receptor [PDF]

open access: yes, 1992
The general feasibility of chimerization of monoclonal antibodies (mAbs) has already been shown for a large number of them. In order to evaluate in vitro parameters relevant to immunosuppressive therapy, we have chimerized and synthesized two anti-CD4 ...
Schwirzke, Marina   +10 more
core   +1 more source

Fulminant Myocarditis in Patients With Autoimmune Disease That Requires Extracorporeal Membrane Oxygenation Support [PDF]

open access: yesTexas Heart Institute Journal
Myocarditis is a potentially life-threatening inflammatory disease of the myocardium, often resulting from infectious and immune-mediated responses. Clinical presentation in severe cases often results in a devastating illness requiring extracorporeal ...
Filip Depta, MD, PhD   +5 more
doaj   +1 more source

Cellular Therapies for Immunosuppression [PDF]

open access: yes, 2012
Almost all current therapeutic approaches to inhibit destructive immune responses in autoimmunity are based on antigen non-specific agents, such as cyclosporine A, which systemically suppress the function of virtually all immune effector cells.
Cools, Nathalie   +2 more
openaire   +2 more sources

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