Results 81 to 90 of about 4,676,099 (307)

Immunosuppressive drugs modulate the replication of hepatitis B virus (HBV) in a hydrodynamic injection mouse model. [PDF]

PLoS ONE, 2014
Hepatitis B virus (HBV) reactivation and recurrence are common in patients under immunosuppression and can be controlled by hepatitis B immunoglobulin, antivirals, and hepatitis B vaccine.
Junzhong Wang, Baoju Wang, Shunmei Huang, Zhitao Song, Jun Wu, Ejuan Zhang, Zhenni Zhu, Bin Zhu, Ying Yin, Yong Lin, Yang Xu, Xin Zheng, Mengji Lu, Dongliang Yang   +13 more
doaj   +1 more source

Transplantation Without Overimmunosuppression (TWO) study protocol: a phase 2b randomised controlled single-centre trial of regulatory T cell therapy to facilitate immunosuppression reduction in living donor kidney transplant recipients

BMJ Open, 2022
Introduction Regulatory T cell (Treg) therapy has been demonstrated to facilitate long-term allograft survival in preclinical models of transplantation and may permit reduction of immunosuppression and its associated complications in the clinical setting.
Susan Dutton, Ines Rombach, Joanna Black, Paul Harden, Giovanna Lombardi, William Petchey, Kathryn Wood, Fadi Issa, Matthew Oliver Brook, Joanna Hester, Matthew James Bottomley, Seetha Abdul-Wahab, Andrew Bushell, Peter Friend   +13 more
doaj   +1 more source

Successful recovery of COVID-19 pneumonia in a renal transplant recipient with long-term immunosuppression

American Journal of Transplantation, 2020
The current outbreak of Coronavirus Disease 2019 (COVID‐19) has raised great concern worldwide, but its impact on transplant recipients is unknown.
Lan Zhu, Xizhen Xu, Ke Ma, Junling Yang, Hanxiong Guan, Song Chen, Zhishui Chen, Gang Chen   +7 more
semanticscholar   +1 more source

In Silico Implementation of Evolutionary Paradigm in Therapy Design: Towards Anti-Cancer Therapy as Darwinian Process [PDF]

Journal of Theoretical Biology 485(2020) 110038, 2018
In here presented in silico study we suggest a way how to implement the evolutionary principles into anti-cancer therapy design. We hypothesize that instead of its ongoing supervised adaptation, the therapy may be constructed as a self-sustaining evolutionary process in a dynamic fitness landscape established implicitly by evolving cancer cells ...
arxiv   +1 more source

Targeting immunosuppression for cancer therapy [PDF]

Journal of Clinical Investigation, 2013
Failing immunity has been acknowledged for its contribution to cancer development and progression. Recent clinical findings have provided payoffs for significant preclinical evaluation and refinement over the last 20 years, but many questions remain to be answered. In this issue of the JCI, Marabelle et al.
Cristina Ghirelli, Thorsten Hagemann
openaire   +3 more sources

Analysis of early use of everolimus with low-dose calcineurin inhibitors in kidney transplant recipient

Вестник трансплантологии и искусственных органов, 2019
Aim: to evaluate the efficacy and safety of early use of everolimus in combination with a reduced dose of calcineurin inhibitors (CNI) after kidney transplantation and define approaches to the selection and management of patients on everolimus-based ...
I. G. Kim, N. A. Tomilina, I. V. Ostrovskaya, I. A. Skryabina, N. D. Fedorova   +4 more
doaj   +1 more source

Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy [PDF]

, 1984
Post-transplant lymphomas or other lymphoproliferative lesions, which were usually associated with Epstein-Barr virus infections, developed in 8, 4, 3, and 2 recipients, respectively, of cadaveric kidney, liver, heart, and heart-lung homografts ...
Atchison, RW, Bahnson, HT, Griffith, BP, Hakala, TR, Hardesty, RL, Ho, M, Iwatsuki, S, Jaffe, R, Nalesnik, MA, Porter, KA, Rosenthal, JT, Shaw, BW, Starzl, TE   +12 more
core   +1 more source

Shedding of Viable SARS-CoV-2 after Immunosuppressive Therapy for Cancer

New England Journal of Medicine, 2020
Shedding of SARS-CoV-2 after Immunosuppression The prolonged contagious period after viral infection in immunocompromised patients may affect how long precautions will be necessary to reduce furthe...
T. Aydillo, A. Gonzalez-Reiche, S. Aslam, A. van de Guchte, Z. Khan, Ajay Obla, Jayeeta Dutta, H. van Bakel, J. Aberg, A. García-Sastre, G. Shah, T. Hohl, G. Papanicolaou, M. Perales, K. Sepkowitz, N. Babady, M. Kamboj   +16 more
semanticscholar   +1 more source

Spatio-temporal modeling of co-dynamics of smallpox, measles and pertussis in pre-healthcare Finland [PDF]

arXiv, 2023
Infections are known to interact as previous infections may have an effect on risk of succumbing to a new infection. The co-dynamics can be mediated by immunosuppression or -modulation, shared environmental or climatic drivers, or competition for susceptible hosts.
arxiv  

Immunosuppressive therapies in myasthenia gravis

Autoimmunity, 2010
Immunosuppression is the mainstay of treatment for myasthenia gravis (MG). In this paper, we review the mechanisms of action and clinical application of corticosteroids and different classes of immunosuppressive drugs that are currently used in MG patients, and present the results of their use in more than 1000 patients with MG seen at our two centers.
Sanders, Donald, Evoli, Amelia
openaire   +3 more sources