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Fine-tuning the antigen sensitivity of CAR T cells: emerging strategies and current challenges
Chimeric antigen receptor (CAR) T cells are “living drugs” that specifically recognize their target antigen through an antibody-derived binding domain resulting in T cell activation, expansion, and destruction of cognate target cells.
Dennis Christoph Harrer+7 more
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The advent of chimeric antigen receptor (CAR) T cells expedited the field of cancer immunotherapy enabling durable remissions in patients with refractory hematological malignancies.
Dennis Christoph Harrer+9 more
doaj +1 more source
Anti-TACI single and dual-targeting CAR T cells overcome BCMA antigen loss in multiple myeloma
Chimeric Antigen Receptor (CAR) T cells directed to B cell maturation antigen (BCMA) mediate profound responses in patients with multiple myeloma, but most patients do not achieve long-term complete remissions.
Rebecca C. Larson+14 more
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Background B7 homology 4 (B7-H4), a potential target for cancer therapy, has been demonstrated to inhibit T cell cytotoxicity in the early stages of breast cancer.
Linlin Zhou+7 more
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IRF4 downregulation improves sensitivity and endurance of CAR T cell functional capacities
Chimeric antigen receptor (CAR) modified T cells can induce complete remissions in patients with advanced hematological malignancies. Nevertheless, the efficacy is mostly transient and remains so far poor in the treatment of solid tumors.
Dennis Christoph Harrer+5 more
doaj +1 more source
Intratumoral co‐injection of NK cells and NKG2A‐neutralizing monoclonal antibodies
NK‐cell reactivity against cancer is conceivably suppressed in the tumor microenvironment by the interaction of the inhibitory receptor NKG2A with the non‐classical MHC‐I molecules HLA‐E in humans or Qa‐1b in mice.
Ignacio Melero+13 more
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HIV envelope is a target for vaccine development, but induction of broadly neutralizing antibodies has been difficult. Here, the authors show that electroporation with a synthetic DNA vaccine construct allows in vivo production of HIV envelope native ...
Ziyang Xu+25 more
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A biomathematical model of tumor response to radioimmunotherapy with $α$PDL1 and $α$CTLA4 [PDF]
There is evidence of synergy between radiotherapy and immunotherapy. Radiotherapy can increase liberation of tumor antigens, causing activation of antitumor T-cells. This effect can be boosted with immunotherapy. Radioimmunotherapy has potential to increase tumor control rates.
arxiv +1 more source
Previous studies have shown that local delivery of tumor antigen-specific CD8+ T lymphocytes engineered to transiently express single-chain IL-12 mRNA is highly efficacious.
Claudia Augusta Di Trani+16 more
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Molecular MRI-Based Monitoring of Cancer Immunotherapy Treatment Response [PDF]
Immunotherapy constitutes a paradigm shift in cancer treatment. Its FDA approval for several indications has yielded improved prognosis for cases where traditional therapy has shown limited efficiencey. However, many patients still fail to benefit from this treatment modality, and the exact mechanisms responsible for tumor response are unknown ...
arxiv +1 more source