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Fine-tuning the antigen sensitivity of CAR T cells: emerging strategies and current challenges
Frontiers in Immunology, 2023 Chimeric antigen receptor (CAR) T cells are “living drugs” that specifically recognize their target antigen through an antibody-derived binding domain resulting in T cell activation, expansion, and destruction of cognate target cells.
Dennis Christoph Harrer +7 more
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Cells, 2022 The advent of chimeric antigen receptor (CAR) T cells expedited the field of cancer immunotherapy enabling durable remissions in patients with refractory hematological malignancies.
Dennis Christoph Harrer +9 more
doaj +1 more source
Food allergy immunotherapy: Oral immunotherapy and epicutaneous immunotherapy [PDF]
Allergy, 2020 AbstractIgE‐mediated food allergy remains a significant and growing problem across the globe. Of the various treatment modalities, oral immunotherapy (OIT) and epicutaneous immunotherapy (EPIT) have been the best studied. Across various studies of OIT for egg, milk, and peanut allergy, strong levels of desensitization have been shown.
Edwin H. Kim, Arvil Wesley Burks
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Repression of the stress granule protein G3BP2 inhibits immune checkpoint molecule PD‐L1
Molecular Oncology, EarlyView., 2022 Mounting evidence suggests that cancer stemness and immunosuppression are related, but the underlying mechanisms are not clear. We previously reported that the stress granule‐associated protein G3BP2 is involved in regulating tumor‐initiating (stem) cells.
Yanhong Zhang +3 more
wiley +1 more source
Anti-TACI single and dual-targeting CAR T cells overcome BCMA antigen loss in multiple myeloma
Nature Communications, 2023 Chimeric Antigen Receptor (CAR) T cells directed to B cell maturation antigen (BCMA) mediate profound responses in patients with multiple myeloma, but most patients do not achieve long-term complete remissions.
Rebecca C. Larson +14 more
doaj +1 more source
Immunotherapy of aspergillosis [PDF]
Clinical Microbiology and Infection, 2012 Management of invasive aspergillosis in high-risk patients remains challenging. There is an increasing demand for novel therapeutic strategies aimed at enhancing or restoring antifungal immunity in immunocompromised patients. In this regard, modulation of specific innate immune functions and vaccination are promising immunotherapeutic strategies ...
Cristina Cunha +4 more
openaire +4 more sources
Breast Cancer Research, 2023 Background B7 homology 4 (B7-H4), a potential target for cancer therapy, has been demonstrated to inhibit T cell cytotoxicity in the early stages of breast cancer.
Linlin Zhou +7 more
doaj +1 more source
IRF4 downregulation improves sensitivity and endurance of CAR T cell functional capacities
Frontiers in Immunology, 2023 Chimeric antigen receptor (CAR) modified T cells can induce complete remissions in patients with advanced hematological malignancies. Nevertheless, the efficacy is mostly transient and remains so far poor in the treatment of solid tumors.
Dennis Christoph Harrer +5 more
doaj +1 more source
Immunotherapy for neurodegeneration? [PDF]
Science, 2019 The role of innate and adaptive immunity in neurodegeneration remains ...
Liu, Yingjun, Aguzzi, Adriano
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Intratumoral co‐injection of NK cells and NKG2A‐neutralizing monoclonal antibodies
EMBO Molecular Medicine, 2023 NK‐cell reactivity against cancer is conceivably suppressed in the tumor microenvironment by the interaction of the inhibitory receptor NKG2A with the non‐classical MHC‐I molecules HLA‐E in humans or Qa‐1b in mice.
Ignacio Melero +13 more
doaj +1 more source