Results 11 to 20 of about 327,034 (336)

Adoptive Immunotherapy in Chimeras with Donor Lymphocytes [PDF]

Acta Haematologica, 2003
Allogeneic stem cell transplantation has a well-defined indication in the treatment of hematological malignancies. The beneficial immune effect of allogeneic marrow transplantation has long been known, but only recently have methods been developed to separate the graft-versus-leukemia (GVL) effect from graft-versus-host disease (GVHD).
Kolb, Hans-Jochem, Schmid, Christoph, Chen, Xiao, Woiciechowski, Anja, Roskrow, Marie, Weber, Martin, Guenther, Wolfgang, Ledderose, Georg, Schleuning, Michael   +8 more
openaire   +7 more sources

CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy

Nature Communications, 2021
The immunosuppressive tumor microenvironment (TME) represents a major barrier for effective immunotherapy. Tumor-associated macrophages (TAMs) are highly heterogeneous and plastic cell components of the TME which can either promote tumor progression (M2 ...
A. Rodríguez-García, Rachel C. Lynn, M. Poussin, Monika A. Eiva, Lauren Shaw, Roddy S. O’Connor, Nicholas G. Minutolo, Victoria Casado-Medrano, Gonzalo Lopez, T. Matsuyama, D. Powell   +10 more
semanticscholar   +1 more source

Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy

Nature Biomedical Engineering, 2021
Malignant transformation and tumour progression are associated with cancer-cell softening. Yet how the biomechanics of cancer cells affects T-cell-mediated cytotoxicity and thus the outcomes of adoptive T-cell immunotherapies is unknown.
Kewen Lei, Armand Kurum, Murat Kaynak, Lucia Bonati, Y. Han, Veronika Cencen, Min Gao, Yu-Qing Xie, Yugang Guo, M. Hannebelle, Yangping Wu, Guanyu Zhou, Ming Guo, G. Fantner, M. Sakar, Li Tang   +15 more
semanticscholar   +1 more source

Tracking adoptive T cell immunotherapy using magnetic particle imaging

Nanotheranostics, 2021
Adoptive cellular therapy (ACT) is a potent strategy to boost the immune response against cancer. ACT is effective against blood cancers but faces challenges in treating solid tumors.
Angelie Rivera-Rodriguez, L. Hoang-Minh, Andreina Chiu-Lam, Nicole S Sarna, Leyda Marrero-Morales, D. Mitchell, Carlos M. Rinaldi‐Ramos   +6 more
semanticscholar   +1 more source

A novel and effective cancer immunotherapy mouse model using antigen-specific B cells selected in vitro. [PDF]

PLoS ONE, 2014
Immunotherapies such as adoptive transfer of T cells or natural killer cells, or monoclonal antibody (MoAb) treatment have recently been recognized as effective means to treat cancer patients.
Tatsuya Moutai, Hideyuki Yamana, Takuya Nojima, Daisuke Kitamura   +3 more
doaj   +1 more source

Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

Science, 2020
Stem-like T cells mediate response Adoptive cell transfer (ACT) is a type of immunotherapy that uses a patient's own T lymphocytes to recognize and attack cancer.
S. Krishna, Frank J. Lowery, Amy R. Copeland, Erol Bahadiroglu, Ratnadeep Mukherjee, Li Jia, J. Anibal, Abraham Sachs, Serifat Adebola, Devikala Gurusamy, Zhiya Yu, Victoria K. Hill, J. Gartner, Yong F Li, M. Parkhurst, B. Paria, P. Kvistborg, Michael C. Kelly, Stephanie L. Goff, G. Altan-Bonnet, P. Robbins, S. Rosenberg   +21 more
semanticscholar   +1 more source

Review of precision cancer medicine: Evolution of the treatment paradigm. [PDF]

, 2020
In recent years, biotechnological breakthroughs have led to identification of complex and unique biologic features associated with carcinogenesis. Tumor and cell-free DNA profiling, immune markers, and proteomic and RNA analyses are used to identify ...
Fountzilas, Elena, Kurzrock, Razelle, Nikanjam, Mina, Tsimberidou, Apostolia M   +3 more
core   +1 more source

The Current Application and Future Prospects of Astragalus Polysaccharide Combined With Cancer Immunotherapy: A Review

Frontiers in Pharmacology, 2021
So far, immunotherapy has been shown to have impressive effects on different cancers in clinical trials. All those immunotherapies are generally derived from three main therapeutic approaches: immune checkpoint inhibitors, immune cell vaccination, and ...
Fanming Kong, Fanming Kong, Tianqi Chen, Tianqi Chen, Xiaojiang Li, Xiaojiang Li, Yingjie Jia, Yingjie Jia   +7 more
doaj   +1 more source

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer [PDF]

, 2012
A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly.
A Lundqvist, A Somers, C Berger, CA Tran, Carolina Berger, Cornelis JM Melief, Daniel J Powell, David F Stroncek, DG Song, DJ Powell Jr, DL Porter, Francesco M Marincola, G Mostoslavsky, GG Kenter, Gustavo Mostoslavsky, J Jin, J Staerk, James R Heath, Jeffrey S Miller, JN Kochenderfer, JN Kochenderfer, John O'Shea, JS Miller, K Takahashi, L Gattinoni, L Gattinoni, L Gattinoni, L Gattinoni, LA Johnson, Luca Gattinoni, M Kalos, M Kalos, M Kalos, Mahendra Rao, Mark E Dudley, Martin A Cheever, ME Dudley, ME Dudley, Michael Kalos, Nicholas P Restifo, P Muranski, Peter Flynn, PF Robbins, RA Morgan, Richard W Childs, SA Rosenberg, Steven A Rosenberg, TS Park, X Wang   +48 more
core   +4 more sources

Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy [PDF]

, 2020
Chimeric antigen receptor (CAR) T-cell therapy has produced remarkable anti-tumor responses in patients with B-cell malignancies. However, clonal kinetics and transcriptional programs that regulate the fate of CAR-T cells after infusion remain poorly ...
Adair, Jennifer E., DeBerg, Hannah A., Enstrom, Mark R., Gersuk, Vivian, Gottardo, Raphaël, Hanafi, Laïla-Aïcha, Hawkins, Reed, Kiem, Hans-Peter, Linsley, Peter S., Maloney, David G., Pande, Dnyanada, Riddell, Stanley R., Sheih, Alyssa, Turtle, Cameron J., Voillet, Valentin, Wohlfahrt, Martin E., Yajima, Masanao   +16 more
core   +1 more source