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CASE FOR ADOPTIVE IMMUNOTHERAPY IN CANCER
The Lancet, 1982Patients with normal immune systems may be unable to mount effective defences against solid tumours because of (1) the generation of suppressor T cells in the low zone tolerance response elicited by the low concentrations of antigen furnished by slow growing solid tumours; (2) the ineffectiveness of the cytolytic T-cell response when the tumour cell ...
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Adoptive immunotherapy for herpesviruses
2007Herpesvirus infections rarely cause significant problems in the immunocompetent human host. However, in the immunosuppressed, for example, recipients of hematopoietic stem cell transplants (HSCT) (Rooney et al., 1998), solid organ transplants (SOT), or human immunodeficiency virus (HIV)-infected individuals, viral infections/reactivations are common ...
Ann M. Leen +3 more
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Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies
Cancer Cell, 2020Douglas Palmer +2 more
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