Results 41 to 50 of about 944,744 (294)

Enhancement of electroporation facilitated immunogene therapy via T-reg depletion [PDF]

, 2014
Regulatory T cells (T-regs) can negatively impact tumor antigen-specific immune responses after infiltration into tumor tissue. However, depletion of T-regs can facilitate enhanced anti-tumor responses, thus augmenting the potential for immunotherapies ...
A Testori, AMM Eggermont, C Collins, D Alston, D M Soden, F Erdmann, F Tas, G C O' Sullivan, G Tevz, I Martínez-Lacaci, JFM Jacobs, L Finn, L Heller, L J Hall, M de Kruijf, M Sadadcharam, M Tangney, MC Whelan, MC Whelan, ML Lucas, P F Forde, R Dummer, S Bhatia, T R O' Donovan, TJ Curiel, TR Wilson, W L Byrne, W Zou, W Zou   +28 more
core   +1 more source

Expression of TIM3/VISTA checkpoints and the CD68 macrophage-associated marker correlates with anti-PD1/PDL1 resistance: implications of immunogram heterogeneity. [PDF]

, 2020
Although immunotherapies have achieved remarkable salutary effects among subgroups of advanced cancers, most patients do not respond. We comprehensively evaluated biomarkers associated with the "cancer-immunity cycle" in the pan-cancer setting in order ...
Dressman, Devin, Eskander, Ramez, Glenn, Sean T, Goodman, Aaron, Ikeda, Sadakatsu, Kato, Shumei, Kumaki, Yuichi, Kurzrock, Razelle, Lee, Suzanna, Lenzo, Felicia L, Morrison, Carl, Nikanjam, Mina, Okamura, Ryosuke, Papanicolau-Sengos, Antonios   +13 more
core   +1 more source

Immunotherapy of lung cancer: An update [PDF]

, 2006
In Germany lung cancer is the leading cause of cancer-associated death in men. Surgery, chemotherapy and radiation may enhance survival of patients suffering from lung cancer but the enhancement is typically transient and mostly absent with advanced ...
Aman MJ, Anthony HM, Atanackovic D, Bast RC, Bermers AJA, Carbone FR, Chan B, Cohen MH, Dickler M, Dranoff G, Dudley ME, Faradji A, Gotoh K, Grant SC, Kimura H, Kimura Y, Korkolopoulou P, Kradin RL, Krug LM, Krug LM, Liu M, Ma J, Marshall JL, Melioli G, Millar JW, Nemunaitis J, Nikitina E, O'Brien ME, Palmer M, Raez LE, Ratto GB, Salgia R, Smith A, Sterman D, Swisher S, Villalona-Calero MA, Yano T   +36 more
core   +1 more source

Adoptive Immunotherapy in Chimeras with Donor Lymphocytes [PDF]

, 2003
Allogeneic stem cell transplantation has a well-defined indication in the treatment of hematological malignancies. The beneficial immune effect of allogeneic marrow transplantation has long been known, but only recently have methods been developed to ...
Chen, Xiao, Guenther, Wolfgang, Kolb, Hans-Jochem, Ledderose, Georg, Roskrow, Marie, Schleuning, Michael, Schmid, Christoph, Weber, Martin, Woiciechowski, Anja   +8 more
core   +1 more source

Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy

Signal Transduction and Targeted Therapy, 2022
In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors respond poorly or even not to ICIs, partly caused by the absence of tumor ...
W. Gao, Xuepeng Wang, Yang Zhou, Xuepeng Wang, Yan Yu   +4 more
semanticscholar   +1 more source

Abscopal Effects of Local Radiotherapy Are Dependent on Tumor Immunogenicity

Frontiers in Oncology, 2021
Although abscopal tumor regression remains a rare phenomenon, interest in exploiting how radiation stimulates the immune system to induce systemic abscopal response is increasing.
Jin-Zhi Lai, Jin-Zhi Lai, Yan-Yang Zhu, Ying Liu, Lin-Lin Zhou, Li Hu, Ling Chen, Qiu-Yu Zhang   +7 more
doaj   +1 more source

CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy

Nature, 2019
Cancer immunotherapy restores or enhances the effector function of CD8+ T cells in the tumour microenvironment1,2. CD8+ T cells activated by cancer immunotherapy clear tumours mainly by inducing cell death through perforin–granzyme and Fas–Fas ligand ...
Weimin Wang, Michael F. Green, J. E. Choi, M. Gijon, Paul D. Kennedy, Jeffrey K. Johnson, P. Liao, Xueting Lang, Ilona Kryczek, Amanda Sell, Houjun Xia, Jiajia Zhou, Gaopeng Li, Jing Li, Wei Li, Shuang Wei, Linda Vatan, Hongjuan Zhang, Wojciech Szeliga, W. Gu, Rebecca J Liu, T. Lawrence, Candice Lamb, Yuri Tanno, M. Cieslik, E. Stone, G. Georgiou, T. Chan, A. Chinnaiyan, W. Zou   +29 more
semanticscholar   +1 more source

B cells are associated with survival and immunotherapy response in sarcoma

Nature, 2020
Soft-tissue sarcomas represent a heterogeneous group of cancer, with more than 50 histological subtypes1,2. The clinical presentation of patients with different subtypes is often atypical, and responses to therapies such as immune checkpoint blockade ...
F. Petitprez, A. Reyniès, E. Keung, T. Chen, Cheng-Ming Sun, J. Calderaro, Y. Jeng, Li-Ping Hsiao, L. Lacroix, A. Bougoüin, M. Moreira, Guillaume Lacroix, Ivo Natario, J. Adam, C. Lucchesi, Y. Laizet, M. Toulmonde, M. Burgess, V. Bolejack, D. Reinke, K. Wani, Wei-Lien Wang, A. Lazar, C. Roland, J. Wargo, A. Italiano, C. Sautès-Fridman, H. Tawbi, W. Fridman   +28 more
semanticscholar   +1 more source

Immunotherapy

International Journal of Clinical Practice, 1989
A new era of immunotherapy is arriving in medical therapeutics. Both immunosupresion and immunomodulation have advantages which the clinician must learn. In this review, the author describe several immunomodulators which include cytokines, interleukins, interferons, tumor necrosis factor, granulocyte colony-stimulating factor, erythropoietin, and ...
openaire   +4 more sources

Immunotherapy with peptides [PDF]

Allergy, 2011
Specific allergen immunotherapy is clinically effective and disease modifying. It has a duration of effect that exceeds the treatment period and prevents both the progression of allergic rhinitis to asthma and the acquisition of new allergic sensitizations.
Daniel M. Moldaver, Mark Larché
openaire   +3 more sources