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Bulletin du cancer, 1983
Immunotoxins are conjugates between antibodies especially directed against cancer cells and a subunit of a powerful toxin. We used the A-chain of ricin. These conjugates are specifically cytotoxic when used at very low concentrations in vitro and can destroy more than 99.99% of clonogenic cells.
F K, Jansen +13 more
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Immunotoxins are conjugates between antibodies especially directed against cancer cells and a subunit of a powerful toxin. We used the A-chain of ricin. These conjugates are specifically cytotoxic when used at very low concentrations in vitro and can destroy more than 99.99% of clonogenic cells.
F K, Jansen +13 more
openaire +1 more source
Pseudomonas exotoxin — Immunotoxins
1988Monoclonal antibodies can be coupled with PE to make very potent ITs. Two of these ITs (PE-HB21 and OVB-3-PE) have been shown to have antitumor activity in a nude mouse model of ovarian cancer. PE ITs are at least 10-fold more active than the corresponding RTA IT.
D J, FitzGerald +2 more
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Genetic engineering of immunotoxins
1988Genetic engineering offers many advantages for the 1) production of immunotoxins (ITs) and 2) design of more effective reagents. In Chapter 9, J.R. Murphy discusses the use of genetic engineering to link genes together resulting in chimeric proteins. This review covers the first applications of genetic engineering technology to improve ITs by studying ...
R J, Youle, L, Greenfield, V G, Johnson
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