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Expert Opinion on Pharmacotherapy, 2000
Immunotoxins are molecules which contain a protein toxin connected to a targeting antibody. The goal of therapy is for the molecule to bind selectively to cancer cells, or to cells mediating autoimmune disease, internalise and then for the toxin to kill the cell.
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Immunotoxins are molecules which contain a protein toxin connected to a targeting antibody. The goal of therapy is for the molecule to bind selectively to cancer cells, or to cells mediating autoimmune disease, internalise and then for the toxin to kill the cell.
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Neurosurgery Clinics of North America, 1996
Immunotoxins are extremely potent agents that recognize specific antigens located on metastatic tumor cells and cause cytotoxicity after cell entry by inhibiting protein synthesis. These agents have considerable in vitro efficacy against numerous metastatic tumor cell lines.
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Immunotoxins are extremely potent agents that recognize specific antigens located on metastatic tumor cells and cause cytotoxicity after cell entry by inhibiting protein synthesis. These agents have considerable in vitro efficacy against numerous metastatic tumor cell lines.
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Immunotoxins and Recombinant Immunotoxins in Cancer Therapy
2006Targeted cancer therapy in general and immunotherapy in particular, combines rational drug design with the progress in understanding cancer biology. This approach takes advantage of our recent knowledge of the mechanisms by which normal cells are transformed into cancer cells, thus, using the special properties of cancer cells to device novel ...
Yoram Reiter, Avital Lev
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1997
Abstract Immunotoxins (ITs) are cell type-specific cytotoxic agents consisting of an antibody linked to a protein toxin. The antibody component is responsible for directing the toxin selectively to the target cell and the toxin component is responsible for killing the cell (for reviews on ITs see refs 1—5).
Elaine J Derbyshire +2 more
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Abstract Immunotoxins (ITs) are cell type-specific cytotoxic agents consisting of an antibody linked to a protein toxin. The antibody component is responsible for directing the toxin selectively to the target cell and the toxin component is responsible for killing the cell (for reviews on ITs see refs 1—5).
Elaine J Derbyshire +2 more
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Bulletin du cancer, 1983
Immunotoxins are conjugates between antibodies especially directed against cancer cells and a subunit of a powerful toxin. We used the A-chain of ricin. These conjugates are specifically cytotoxic when used at very low concentrations in vitro and can destroy more than 99.99% of clonogenic cells.
F K, Jansen +13 more
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Immunotoxins are conjugates between antibodies especially directed against cancer cells and a subunit of a powerful toxin. We used the A-chain of ricin. These conjugates are specifically cytotoxic when used at very low concentrations in vitro and can destroy more than 99.99% of clonogenic cells.
F K, Jansen +13 more
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Pseudomonas exotoxin — Immunotoxins
1988Monoclonal antibodies can be coupled with PE to make very potent ITs. Two of these ITs (PE-HB21 and OVB-3-PE) have been shown to have antitumor activity in a nude mouse model of ovarian cancer. PE ITs are at least 10-fold more active than the corresponding RTA IT.
D J, FitzGerald +2 more
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Genetic engineering of immunotoxins
1988Genetic engineering offers many advantages for the 1) production of immunotoxins (ITs) and 2) design of more effective reagents. In Chapter 9, J.R. Murphy discusses the use of genetic engineering to link genes together resulting in chimeric proteins. This review covers the first applications of genetic engineering technology to improve ITs by studying ...
R J, Youle, L, Greenfield, V G, Johnson
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