Results 171 to 180 of about 7,988 (196)
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Molecular and chemical neuropathology, 1994
Immunotoxins are being tested for the therapy of systemic cancer and brain tumors. Neurotoxicity has been dose limiting for several of these antibody conjugates given systemically. We review the animal and clinical data related to the neurotoxicity of immunotoxins in attempt to understand the molecular basis for the unexpected neural involvement and to
O, Ilercil +5 more
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Immunotoxins are being tested for the therapy of systemic cancer and brain tumors. Neurotoxicity has been dose limiting for several of these antibody conjugates given systemically. We review the animal and clinical data related to the neurotoxicity of immunotoxins in attempt to understand the molecular basis for the unexpected neural involvement and to
O, Ilercil +5 more
openaire +2 more sources
Bulletin du cancer, 1983
Immunotoxins are conjugates between antibodies especially directed against cancer cells and a subunit of a powerful toxin. We used the A-chain of ricin. These conjugates are specifically cytotoxic when used at very low concentrations in vitro and can destroy more than 99.99% of clonogenic cells.
F K, Jansen +13 more
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Immunotoxins are conjugates between antibodies especially directed against cancer cells and a subunit of a powerful toxin. We used the A-chain of ricin. These conjugates are specifically cytotoxic when used at very low concentrations in vitro and can destroy more than 99.99% of clonogenic cells.
F K, Jansen +13 more
openaire +1 more source
Pseudomonas exotoxin — Immunotoxins
1988Monoclonal antibodies can be coupled with PE to make very potent ITs. Two of these ITs (PE-HB21 and OVB-3-PE) have been shown to have antitumor activity in a nude mouse model of ovarian cancer. PE ITs are at least 10-fold more active than the corresponding RTA IT.
D J, FitzGerald +2 more
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1997
Abstract Immunotoxins (ITs) are cell type-specific cytotoxic agents consisting of an antibody linked to a protein toxin. The antibody component is responsible for directing the toxin selectively to the target cell and the toxin component is responsible for killing the cell (for reviews on ITs see refs 1—5).
Elaine J Derbyshire +2 more
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Abstract Immunotoxins (ITs) are cell type-specific cytotoxic agents consisting of an antibody linked to a protein toxin. The antibody component is responsible for directing the toxin selectively to the target cell and the toxin component is responsible for killing the cell (for reviews on ITs see refs 1—5).
Elaine J Derbyshire +2 more
openaire +1 more source
1988
Bacterial and plant toxins composed of different protein subunits with diverse biological functions have provided an investigational focal point for researchers in many areas of specialization. Potent catalytic toxins have been linked to monoclonal antibodies (MoAb) for antibody directed cell targeting.
D A, Vallera, D E, Myers
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Bacterial and plant toxins composed of different protein subunits with diverse biological functions have provided an investigational focal point for researchers in many areas of specialization. Potent catalytic toxins have been linked to monoclonal antibodies (MoAb) for antibody directed cell targeting.
D A, Vallera, D E, Myers
openaire +2 more sources
Immunotoxins and Recombinant Immunotoxins in Cancer Therapy
2006Targeted cancer therapy in general and immunotherapy in particular, combines rational drug design with the progress in understanding cancer biology. This approach takes advantage of our recent knowledge of the mechanisms by which normal cells are transformed into cancer cells, thus, using the special properties of cancer cells to device novel ...
Yoram Reiter, Avital Lev
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