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Genetic engineering of immunotoxins
1988Genetic engineering offers many advantages for the 1) production of immunotoxins (ITs) and 2) design of more effective reagents. In Chapter 9, J.R. Murphy discusses the use of genetic engineering to link genes together resulting in chimeric proteins. This review covers the first applications of genetic engineering technology to improve ITs by studying ...
R J, Youle, L, Greenfield, V G, Johnson
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Immunotoxins in cancer therapy
Current Opinion in Immunology, 1999Immunotoxins are composed of a protein toxin connected to a binding ligand such as an antibody or growth factor. These molecules bind to surface antigens (which internalize) and kill cells by catalytic inhibition of protein synthesis within the cell cytosol.
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Anti-cancer Immunotoxins, Challenges, and Approaches
Current Pharmaceutical Design, 2021Leila Rahbarnia +2 more
exaly