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Targeted Toxins in Brain Tumor Therapy [PDF]
Toxins, 2010 Targeted toxins, also known as immunotoxins or cytotoxins, are recombinant molecules that specifically bind to cell surface receptors that are overexpressed in cancer and the toxin component kills the cell.
Walter A. Hall, Yan Michael Li
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Targeted Toxins for the Treatment of Prostate Cancer [PDF]
Biomedicines, 2021 Prostate cancer is the second most common cancer and the fifth leading cause of cancer deaths worldwide. Despite improvements in diagnosis and treatment, new treatment options are urgently needed for advanced stages of the disease.
Philipp Wolf
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Plant-Derived Type I Ribosome Inactivating Protein-Based Targeted Toxins: A Review of the Clinical Experience [PDF]
Toxins, 2022 Targeted toxins (TT) for cancer treatment are a class of hybrid biologic comprised of a targeting domain coupled chemically or genetically to a proteinaceous toxin payload.
David J. Flavell, Sopsamorn U. Flavell
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Toxins, 2018 When considering the geographical expansion of marine toxins, the emergence of new toxins and the associated risk for human health, there is urgent need for versatile and efficient analytical methods that are able to detect a range, as wide as possible ...
Inès Dom +5 more
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Anthrax Toxin: A Pioneer of Targeted Protein Toxins
ToxinsWith anthrax toxin as a pioneer, several bacterial toxins have been engineered to deliver proteins of interest into the cytosol of specific mammalian cells.
Sandy Richter, Gudula Schmidt
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Venom Toxins as Potential Targeted Therapies [PDF]
Toxins, 2019 Targeted therapy has been a very hot research topic in the last decade [...]
Hang Fai Kwok
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Targeting Toxins toward Tumors [PDF]
Molecules, 2021 Many cancer diseases, e.g., prostate cancer and lung cancer, develop very slowly. Common chemotherapeutics like vincristine, vinblastine and taxol target cancer cells in their proliferating states.
Henrik Franzyk +1 more
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Toxins, 2016 The toxic moiety of almost all protein-based targeted toxins must enter the cytosol of the target cell to mediate its fatal effect. Although more than 500 targeted toxins have been investigated in the past decades, no antibody-targeted protein toxin has ...
Hendrik Fuchs +2 more
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An Old Idea Tackling a New Problem: Targeted Toxins Specific for Cancer Stem Cells
Antibodies, 2013 Targeting and killing specific cells discriminately has been the goal of targeted therapy dating back to the era of Paul Ehrlich. The discovery of cancer stem cells has caused a paradigm shift within the cancer field and provided an opportunity to use ...
Daniel A. Vallera, Nate N. Waldron
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Targeted Delivery of Auristatin-Modified Toxins to Pancreatic Cancer Using Aptamers
Molecular Therapy: Nucleic Acids, 2018 Pancreatic cancer is one of the most lethal malignancies. Treatment with the first-line agent, gemcitabine, is often unsuccessful because it, like other traditional chemotherapeutic agents, is non-specific, resulting in off-target effects that ...
Christina Kratschmer, Matthew Levy
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