Enhancing the efficacy of cytotoxic agents for cancer therapy using photochemical internalisation. [PDF]
, 2015 Photochemical internalisation (PCI) is a technique for improving cellular delivery of certain bioactive agents which are prone to sequestration within endolysosomes.
Adigbli +69 more
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Cnidarian Toxins Acting on Voltage-Gated Ion Channels
Marine Drugs, 2006 : Voltage-gated ion channels generate electrical activity in excitable cells. As such, they are essential components of neuromuscular and neuronal systems, and are targeted by toxins from a wide variety of phyla, including the cnidarians. Here, we review
Robert M. Greenberg, Shanta M. Messerli
doaj +1 more source
Phase I clinical study of the recombinant antibody toxin scFv(FRP5)-ETA specific for the ErbB2/HER2 receptor in patients with advanced solid malignomas [PDF]
, 2005 Introduction: ScFv(FRP5)-ETA is a recombinant antibody toxin with binding specificity for ErbB2 (HER2). It consists of an N-terminal single-chain antibody fragment (scFv), genetically linked to truncated Pseudomonas exotoxin A (ETA).
Gunter von Minckwitz +49 more
core +1 more source
Gut-Derived Metabolites and Their Role in Immune Dysfunction in Chronic Kidney Disease
Toxins, 2020 Several of the uremic toxins, which are difficult to remove by dialysis, originate from the gut bacterial metabolism. This opens opportunities for novel targets trying to decrease circulating levels of these toxins and their pathophysiological effects ...
Griet Glorieux +2 more
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New Insights on Saporin Resistance to Chemical Derivatization with Heterobifunctional Reagents
Biomedicines, 2023 Saporin is a type 1 ribosome-inactivating protein widely used as toxic payload in the construction of targeted toxins, chimeric molecules formed by a toxic portion linked to a carrier moiety.
Massimo Bortolotti +4 more
doaj +1 more source
Bacterial protein toxins and lipids: role in toxin targeting and activity [PDF]
Biology of the Cell, 2006 All bacterial toxins, which globally are hydrophilic proteins, interact first with their target cells by recognizing a surface receptor, which is either a lipid or a lipid derivative, or another compound but in a lipid environment. Intracellular active toxins follow various trafficking pathways, the sorting of which is greatly dependent on the nature ...
Blandine, Geny, Michel R, Popoff
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Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms
Cell Reports, 2022 Summary: Targeted delivery of therapeutic proteins toward specific cells and across cell membranes remains major challenges. Here, we develop protein-based delivery systems utilizing detoxified single-chain bacterial toxins such as diphtheria toxin (DT ...
Songhai Tian +5 more
doaj +1 more source
ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice. [PDF]
, 2017 There is a geographic inequality in the incidence of colorectal cancer, lowest in developing countries, and greatest in developed countries.
Li, Peng +3 more
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Targeted Mass Spectrometry Analysis of Clostridium perfringens Toxins
Toxins, 2019 Targeted proteomics recently proved to be a technique for the detection and absolute quantification of proteins not easily accessible to classical bottom-up approaches.
Miloslava Duracova +7 more
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The Molecular Perspective: Targeted Toxins [PDF]
The Oncologist, 2001 are designed, using recombinant DNA technology and imagination, to seek out cancer cells and kill them. Two components are needed: a molecular machine to find cancer cells, and another molecular machine to do the killing. Fortunately, evolution has done much of the work for us.
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