New Insights on Saporin Resistance to Chemical Derivatization with Heterobifunctional Reagents
Biomedicines, 2023 Saporin is a type 1 ribosome-inactivating protein widely used as toxic payload in the construction of targeted toxins, chimeric molecules formed by a toxic portion linked to a carrier moiety.
Massimo Bortolotti +4 more
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Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms
Cell Reports, 2022 Summary: Targeted delivery of therapeutic proteins toward specific cells and across cell membranes remains major challenges. Here, we develop protein-based delivery systems utilizing detoxified single-chain bacterial toxins such as diphtheria toxin (DT ...
Songhai Tian +5 more
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Bacterial protein toxins and lipids: role in toxin targeting and activity [PDF]
Biology of the Cell, 2006 All bacterial toxins, which globally are hydrophilic proteins, interact first with their target cells by recognizing a surface receptor, which is either a lipid or a lipid derivative, or another compound but in a lipid environment. Intracellular active toxins follow various trafficking pathways, the sorting of which is greatly dependent on the nature ...
Blandine, Geny, Michel R, Popoff
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Dihydrodinophysistoxin-1 produced by Dinophysis norvegica in the Gulf of Maine, USA and its accumulation in shellfish [PDF]
, 2020 © The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Deeds, J. R., Stutts, W. L., Celiz, M. D., MacLeod, J., Hamilton, A. E., Lewis, B. J., Miller, D.
Juliette L. Smith +31 more
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Targeted Mass Spectrometry Analysis of Clostridium perfringens Toxins
Toxins, 2019 Targeted proteomics recently proved to be a technique for the detection and absolute quantification of proteins not easily accessible to classical bottom-up approaches.
Miloslava Duracova +7 more
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Human Monocyte-Derived Osteoclasts Are Targeted by Staphylococcal Pore-Forming Toxins and Superantigens. [PDF]
PLoS ONE, 2016 Staphylococcus aureus is the leading cause of bone and joint infections (BJIs). Staphylococcal pathogenesis involves numerous virulence factors including secreted toxins such as pore-forming toxins (PFTs) and superantigens.
Sacha Flammier +6 more
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Life, 2022 Freshwater harmful algal blooms (HABs) are increasing in number and severity worldwide. These HABs are chiefly composed of one or more species of cyanobacteria, also known as blue-green algae, such as Microcystis and Anabaena. Numerous HAB cyanobacterial
Apurva Lad +16 more
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The Molecular Perspective: Targeted Toxins [PDF]
The Oncologist, 2001 are designed, using recombinant DNA technology and imagination, to seek out cancer cells and kill them. Two components are needed: a molecular machine to find cancer cells, and another molecular machine to do the killing. Fortunately, evolution has done much of the work for us.
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The Keratinocyte as a Target for Staphylococcal Bacterial Toxins [PDF]
Journal of Investigative Dermatology Symposium Proceedings, 2001 Skin infections with Staphylococcus aureus are not only an important cause of morbidity and even mortality, but are thought to serve as initiation and/or persistance factors for numerous inflammatory skin diseases, including psoriasis and atopic dermatitis. One mechanism by which S.
Travers, Jeffrey B. +2 more
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Two-Dimensional Layered Nanomaterial-Based Electrochemical Biosensors for Detecting Microbial Toxins
Toxins, 2019 Toxin detection is an important issue in numerous fields, such as agriculture/food safety, environmental monitoring, and homeland security. During the past two decades, nanotechnology has been extensively used to develop various biosensors for achieving ...
Zhuheng Li +4 more
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