Results 11 to 20 of about 156,135 (285)
Venom Toxins as Potential Targeted Therapies [PDF]
Toxins, 2019 Targeted therapy has been a very hot research topic in the last decade [...]
Hang Fai Kwok
doaj +3 more sources
Targeting Toxins toward Tumors [PDF]
Molecules, 2021 Many cancer diseases, e.g., prostate cancer and lung cancer, develop very slowly. Common chemotherapeutics like vincristine, vinblastine and taxol target cancer cells in their proliferating states.
Henrik Franzyk +1 more
doaj +4 more sources
Current status and future directions of botulinum neurotoxins for targeting pain processing. [PDF]
, 2015 Current evidence suggests that botulinum neurotoxins (BoNTs) A1 and B1, given locally into peripheral tissues such as skin, muscles, and joints, alter nociceptive processing otherwise initiated by inflammation or nerve injury in animal models and humans.
Pellett, Sabine +2 more
core +15 more sources
Gene therapy and targeted toxins for glioma. [PDF]
Curr Gene Ther, 2011 The most common primary brain tumor in adults is glioblastoma. These tumors are highly invasive and aggressive with a mean survival time of 15-18 months from diagnosis to death. Current treatment modalities are unable to significantly prolong survival in patients diagnosed with glioblastoma.
Castro MG +12 more
europepmc +4 more sources
Toxins, 2022 Immunotoxins do not only bind to cancer-specific receptors to mediate the elimination of tumor cells through the innate immune system, but also increase target cytotoxicity by the intrinsic toxin activity.
Hossein Panjideh +3 more
doaj +1 more source
Hosts and Heterologous Expression Strategies of Recombinant Toxins for Therapeutic Purposes
Toxins, 2023 The production of therapeutic recombinant toxins requires careful host cell selection. Bacteria, yeast, and mammalian cells are common choices, but no universal solution exists.
Luana di Leandro +3 more
doaj +1 more source
Food Chemistry Advances, 2023 Environmental toxins have the potential to disrupt the animal gut microbiome (AGM), which can lead to various gut-associated diseases such as inflammatory bowel disease (IBD) and colorectal cancer.
Dinesh Nalage +7 more
doaj +1 more source
Aedes cadherin receptor that mediates Bacillus thuringiensis Cry11A toxicity is essential for mosquito development. [PDF]
, 2020 Aedes cadherin (AaeCad, AAEL024535) has been characterized as a receptor for Bacillus thuringiensis subsp. israelensis (Bti) Cry11A toxins. However, its role in development is still unknown.
Aimanova, Karly G +2 more
core +2 more sources
Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology [PDF]
Molecular Cell, 2018 Bacterial toxin-antitoxin (TA) modules are abundant genetic elements that encode a toxin protein capable of inhibiting cell growth and an antitoxin that counteracts the toxin. The majority of toxins are enzymes that interfere with translation or DNA replication, but a wide variety of molecular activities and cellular targets have been described ...
Harms, Alexander +3 more
openaire +5 more sources
"Alternative" endocytic mechanisms exploited by pathogens: new avenues for therapeutic delivery? [PDF]
, 2007 Some pathogens utilize unique routes to enter cells that may evade the intracellular barriers encountered by the typical clathrin-mediated endocytic pathway.
Medina-Kauwe, LK
core +1 more source