Results 11 to 20 of about 1,199,889 (280)
Streptavidin-Saporin: Converting Biotinylated Materials into Targeted Toxins [PDF]
Toxins, 2023 Streptavidin-Saporin can be considered a type of ‘secondary’ targeted toxin. The scientific community has taken advantage of this conjugate in clever and fruitful ways using many kinds of biotinylated targeting agents to send saporin into a cell selected
Leonardo R. Ancheta +4 more
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Strategies to Improve the Clinical Utility of Saporin-Based Targeted Toxins [PDF]
Toxins, 2018 Plant Ribosome-inactivating proteins (RIPs) including the type I RIP Saporin have been used for the construction of Immunotoxins (ITxs) obtained via chemical conjugation of the toxic domain to whole antibodies or by generating genetic fusions to antibody
Francesco Giansanti +4 more
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Gut-Derived Protein-Bound Uremic Toxins
Toxins, 2020 Chronic kidney disease (CKD) afflicts more than 500 million people worldwide and is one of the fastest growing global causes of mortality. When glomerular filtration rate begins to fall, uremic toxins accumulate in the serum and significantly increase ...
Amanda L. Graboski, Matthew R. Redinbo
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A cleavable peptide adapter augments the activity of targeted toxins in combination with the glycosidic endosomal escape enhancer SO1861 [PDF]
BMC BiotechnologyBackground Treatment with tumor-targeted toxins attempts to overcome the disadvantages of conventional cancer therapies by directing a drug’s cytotoxic effect specifically towards cancer cells.
Finn J. Schulze +5 more
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Bacterial Protein Toxins as Anticancer Agents: Clinical Potential of Pseudomonas and Anthrax Toxins
ToxinsProtein toxins are biologically active polypeptides produced by a variety of organisms, including bacteria, plants, fungi, and animals. These molecules exert potent and specific toxic effects on target cells and are primarily associated with ...
Richa Misra +6 more
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Gene Therapy and Targeted Toxins for Glioma [PDF]
Current Gene Therapy, 2011 The most common primary brain tumor in adults is glioblastoma. These tumors are highly invasive and aggressive with a mean survival time of 15-18 months from diagnosis to death. Current treatment modalities are unable to significantly prolong survival in patients diagnosed with glioblastoma.
Maria G, Castro +12 more
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Expanded Haemodialysis as a Current Strategy to Remove Uremic Toxins [PDF]
Toxins, 2021 Chronic kidney disease (CKD) is characterized by the retention of solutes named uremic toxins, which strongly associate with high morbidity and mortality. Mounting evidence suggests that targeting uremic toxins and/or their pathways may decrease the risk
Paola Ciceri, Mario Cozzolino
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Acknowledgment to Reviewers of Toxins in 2020
, 2021 Peer review is the driving force of journal development, and reviewers are gatekeepers who ensure that Toxins maintains its standards for the high quality of its published papers [...
Toxins Editorial Office Toxins Editorial Office
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Toxins, 2022 Immunotoxins do not only bind to cancer-specific receptors to mediate the elimination of tumor cells through the innate immune system, but also increase target cytotoxicity by the intrinsic toxin activity.
Hossein Panjideh +3 more
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Hosts and Heterologous Expression Strategies of Recombinant Toxins for Therapeutic Purposes
Toxins, 2023 The production of therapeutic recombinant toxins requires careful host cell selection. Bacteria, yeast, and mammalian cells are common choices, but no universal solution exists.
Luana di Leandro +3 more
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