Results 51 to 60 of about 156,135 (285)

In Vivo Targets of Pasteurella Multocida Toxin [PDF]

International Journal of Molecular Sciences, 2020
Many Pasteurella multocida strains are carried as commensals, while some cause disease in animals and humans. Some type D strains cause atrophic rhinitis in pigs, where the causative agent is known to be the Pasteurella multocida toxin (PMT). PMT activates three families of G-proteins—Gq/11, G12/13, and Gi/o—leading to cellular mitogenesis and other ...
Arshiya Banu, Alistair J. Lax, Agamemnon E. Grigoriadis   +2 more
openaire   +4 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Targeted Delivery of Auristatin-Modified Toxins to Pancreatic Cancer Using Aptamers

Molecular Therapy: Nucleic Acids, 2018
Pancreatic cancer is one of the most lethal malignancies. Treatment with the first-line agent, gemcitabine, is often unsuccessful because it, like other traditional chemotherapeutic agents, is non-specific, resulting in off-target effects that ...
Christina Kratschmer, Matthew Levy
doaj   +1 more source

Toxic Responses of Different Shellfish Species after Exposure to Prorocentrum lima, a DSP Toxins Producing Dinoflagellate

Toxins, 2022
Prorocentrum lima is a global benthic dinoflagellate that produces diarrhetic shellfish poisoning (DSP) toxins, which can be ingested by filter-feeding bivalves, and eventually pose a great threat to human health through food chain.
Mei-Hua Ye, Da-Wei Li, Qiu-Die Cai, Yu-Hu Jiao, Yang Liu, Hong-Ye Li, Wei-Dong Yang   +6 more
doaj   +1 more source

Impacts of Climate Change on indirect human exposure to pathogens and chemicals from agriculture [PDF]

, 2008
Objective: Climate change is likely to affect the nature of pathogens and chemicals in the environment and their fate and transport. Future risks of pathogens and chemicals could therefore be very different from those of today.
Adhikari A, Alistair B.A. Boxall, Anthony Hardy, David B. Turley, David Stone, Edward Topp, Elizabeth M.H. Wellington, European Communities, Food and Agriculture Organization, Gale P, Giovanni Leonardi, Githecko AK, Gordon Nichols, Haines A, Hawkes C, Kerry Walsh, Laura Burgin, Laura Potts, Leonard S. Levy, Patterson DT, Peter D. Falloon, Philip M. Haygarth, R. Sari Kovats, Richard J. Williams, Sabine Beulke, Simon A. Parsons, Tatiana Boucard, Thomas Hutchinson, van den Berg H   +28 more
core   +5 more sources

The Glucocorticoid Receptor: A Revisited Target for Toxins [PDF]

Toxins, 2010
The hypothalamic-pituitary-adrenal (HPA) axis activation and glucocorticoid responses are critical for survival from a number of bacterial, viral and toxic insults, demonstrated by the fact that removal of the HPA axis or GR blockade enhances mortality rates.
Jeanette I. Webster Marketon, Esther M. Sternberg   +1 more
openaire   +3 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Metabolism of HT-2 Toxin and T-2 Toxin in Oats

Toxins, 2016
The Fusarium mycotoxins HT-2 toxin (HT2) and T-2 toxin (T2) are frequent contaminants in oats. These toxins, but also their plant metabolites, may contribute to toxicological effects. This work describes the use of 13C-assisted liquid chromatography–high-
Jacqueline Meng-Reiterer, Christoph Bueschl, Justyna Rechthaler, Franz Berthiller, Marc Lemmens, Rainer Schuhmacher   +5 more
doaj   +1 more source

Mycotoxin exposure assessments in a multi-center European validation study by 24-hour dietary recall and biological fluid sampling [PDF]

, 2020
The European Food Consumption Validation (EFCOVAL) project includes 600 men and women from Belgium, the Czech Republic, France, the Netherlands, and Norway, who had given serum and 24-hour urine samples, and completed 24-hour dietary recall (24-HDR ...
Abbeddou, Souheila, Arcella, Davide, Claeys, Liesel, De Boevre, Marthe, De Keyzer, Willem, De Ruyck, Karl, De Saeger, Sarah, De Vries, Jeanne, Huybrechts, Inge, Ocke, Marga, Ruprich, Jiri, Yang, Shupeng   +11 more
core   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source