Results 61 to 70 of about 156,135 (285)

Human Mycotoxin Biomonitoring: Conclusive remarks on direct or indirect assessment of urinary deoxynivalenol [PDF]

, 2020
Deoxynivalenol is one of the most ubiquitous mycotoxins in the Western diet through its presence in cereals and cereal products. A vast amount of studies indicate the worrying level of exposure to this toxin, while even high percentages of the population
Bouzaghnane, Nabila, De Boevre, Marthe, De Saeger, Sarah, Vidal Corominas, Arnau   +3 more
core   +1 more source

Non‐targeted Effects of a Targeted Toxin

The FASEB Journal, 2015
Saporin (SAP) alone or conjugated either with stabilized substance P (SSP‐SAP) or with an antibody to dopamine β‐hydroxylase (anti‐DBH‐SAP) leads to attenuation of arterial baroreflexes when injected bilaterally into the nucleus tractus solitarii (NTS) of rats.
William Talman, Deidre Nitschke Dragon, Li‐Hsien Lin   +2 more
openaire   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Mitochondria as a Source and a Target for Uremic Toxins [PDF]

International Journal of Molecular Sciences, 2019
Elucidation of molecular and cellular mechanisms of the uremic syndrome is a very challenging task. More than 130 substances are now considered to be “uremic toxins” and represent a very diverse group of molecules. The toxicity of these molecules affects many cellular processes, and expectably, some of them are able to disrupt mitochondrial functioning.
Vasily A. Popkov, Denis N. Silachev, Arthur O. Zalevsky, Dmitry B. Zorov, Egor Y. Plotnikov   +4 more
openaire   +2 more sources

Structural insights into Clostridium perfringens delta toxin pore formation [PDF]

, 2013
Clostridium perfringens Delta toxin is one of the three hemolysin-like proteins produced by C. perfringens type C and possibly type B strains. One of the others, NetB, has been shown to be the major cause of Avian Nectrotic Enteritis, which following the
AGW Leslie, AH Nguyen, AJ McCoy, Ajit K. Basak, AL Keyburn, Andrea Motta, AP Heuck, AR Cole, B Geny, B Walker, C Jolivet-Reynaud, C Jolivet-Reynaud, C Jolivet-Reynaud, C Jolivet-Reynaud, C Potrich, CG Savva, Christos G. Savva, CL Hatheway, Claire E. Naylor, DC Briggs, DL Theobald, DL Theobald, E Krissinel, F Meyer, G Menestrina, J Huyet, J Rossjohn, JD Pedelacq, JD Thompson, JE Alouf, Jessica Huyet, JM Cavaillon, K Yamashita, L Jayasinghe, L Song, M Fivaz, M Manich, Maryse Gibert, MD Winn, Michel R. Popoff, N Monma, N Stein, O Knapp, P Emsley, P Evans, P Gouet, PV Afonine, R Olson, RK Tweten, S De, S Schwarz, S Sonnino, V Guillet, V Steinthorsdottir, VB Chen, VT Nguyen, Y Moran, Y Tanaka   +57 more
core   +5 more sources

Pediatric Oncology Nursing Competencies in Latin America and the Caribbean: A Scoping Review to Inform Practice, Education, and Research

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Nurses are central to cancer care for children and adolescents, yet no comprehensive synthesis has defined essential core competencies for pediatric oncology nursing (PON) practice internationally, particularly in Latin America and the Caribbean (LAC).
Luís Carlos Lopes‐Júnior, Edmara Bazoni Soares Maia, Soad Fuentes‐Alabí, Courtney E. Sullivan, Monnie Abraham, Mauricio Maza, Liliana Vásquez Ponce, Regina Aparecida Garcia Lima   +7 more
wiley   +1 more source

Clostridial binary toxins: iota and C2 family portraits

Frontiers in Cellular and Infection Microbiology, 2011
There are many pathogenic Clostridium species with diverse virulence factors that include protein toxins. Some of these bacteria, such as C. botulinum, C. difficile, C. perfringens and C. spiroforme, cause enteric problems in animals as well as humans.
Bradley G. Stiles, Darran J. Wigelsworth, Michel R. Popoff, Holger eBarth   +3 more
doaj   +1 more source

Gut-Derived Protein-Bound Uremic Toxins

Toxins, 2020
Chronic kidney disease (CKD) afflicts more than 500 million people worldwide and is one of the fastest growing global causes of mortality. When glomerular filtration rate begins to fall, uremic toxins accumulate in the serum and significantly increase ...
Amanda L. Graboski, Matthew R. Redinbo
doaj   +1 more source

The role of CDC48 in the retro-translocation of non-ubiquitinated toxin substrates in plant cells [PDF]

, 2009
When the catalytic A subunits of the castor bean toxins ricin and Ricinus communis agglutinin (denoted as RTA and RCA A, respectively) are delivered into the endoplasmic reticulum (ER) of tobacco protoplasts, they become substrates for ER ...
Richard S. Marshall, Nicholas A. Jolliffe, Aldo Ceriotti, Christopher J. Snowden, J. Michael Lord, Lorenzo Frigerio, Lynne M. Roberts, Vitale, Romisch, Meusser, Braun, Ye, Rabinovich, Jarosch, Ye, Rape, Lee, Worthington, Kothe, Feiler, Rancour, Muller, Di Cola, Di Cola, Tabe, Hellens, Frigerio, Pedrazzini, Hunter, Chaddock, Jolliffe, Roberts, Campbell, Maliga, Denecke, Klein, Martinez, Allen, Roberts, Wojcik, Dalal, Simpson, Day, Tsai, Bays, Denic, Carvalho, Swanson, Deak, Schuberth, Richly, Yoshida, Yoshida, Wiertz, Brandizzi, Roberts, Lord, Deeks, Wahlman, Wojcik, Carlson, Vashist, Vashist, Caldwell, Schmid, Kirst, Smalle, Carter, Contento, Pimpl   +69 more
core   +1 more source

Target-Driven Evolution of Scorpion Toxins [PDF]

Scientific Reports, 2015
AbstractIt is long known that peptide neurotoxins derived from a diversity of venomous animals evolve by positive selection following gene duplication, yet a force that drives their adaptive evolution remains a mystery. By using maximum-likelihood models of codon substitution, we analyzed molecular adaptation in scorpion sodium channel toxins from a ...
Shangfei Zhang, Bin Gao, Shunyi Zhu
openaire   +2 more sources