Results 61 to 70 of about 1,199,889 (280)
Mitochondria as a Source and a Target for Uremic Toxins [PDF]
International Journal of Molecular Sciences, 2019 Elucidation of molecular and cellular mechanisms of the uremic syndrome is a very challenging task. More than 130 substances are now considered to be “uremic toxins” and represent a very diverse group of molecules. The toxicity of these molecules affects many cellular processes, and expectably, some of them are able to disrupt mitochondrial functioning.
Vasily A. Popkov +4 more
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Retrograde transport pathways utilised by viruses and protein toxins [PDF]
, 2006 A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
J Michael Lord +9 more
core +1 more source
Metabolism of HT-2 Toxin and T-2 Toxin in Oats
Toxins, 2016 The Fusarium mycotoxins HT-2 toxin (HT2) and T-2 toxin (T2) are frequent contaminants in oats. These toxins, but also their plant metabolites, may contribute to toxicological effects. This work describes the use of 13C-assisted liquid chromatography–high-
Jacqueline Meng-Reiterer +5 more
doaj +1 more source
Target-Driven Evolution of Scorpion Toxins [PDF]
Scientific Reports, 2015 AbstractIt is long known that peptide neurotoxins derived from a diversity of venomous animals evolve by positive selection following gene duplication, yet a force that drives their adaptive evolution remains a mystery. By using maximum-likelihood models of codon substitution, we analyzed molecular adaptation in scorpion sodium channel toxins from a ...
Shangfei Zhang, Bin Gao, Shunyi Zhu
openaire +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Acknowledgement to Reviewers of Toxins in 2013
, 2014 The editors of Toxins would like to express their sincere gratitude to the following reviewers for assessing manuscripts in ...
Toxins Editorial Office
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Non‐targeted Effects of a Targeted Toxin
The FASEB Journal, 2015 Saporin (SAP) alone or conjugated either with stabilized substance P (SSP‐SAP) or with an antibody to dopamine β‐hydroxylase (anti‐DBH‐SAP) leads to attenuation of arterial baroreflexes when injected bilaterally into the nucleus tractus solitarii (NTS) of rats.
William Talman +2 more
openaire +1 more source
Acknowledgement to Reviewers of Toxins in 2014
, 2015 The editors of Toxins would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2014:[...
Toxins Editorial Office
core +1 more source