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Penetration Efficiency of Antitumor Agents in Ovarian Cancer Spheroids: The Case of Recombinant Targeted Toxin DARPin-LoPE and the Chemotherapy Drug, Doxorubicin [PDF]
Pharmaceutics, 2019 The efficiency of delivering a therapeutic agent into a tumor is among the crucial factors determining the prospects for its clinical use. This problem is particularly acute in the case of targeted antitumor agents since many of them are high-molecular ...
Evgeniya Sokolova +7 more
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Anthrax Toxin: A Pioneer of Targeted Protein Toxins [PDF]
ToxinsWith anthrax toxin as a pioneer, several bacterial toxins have been engineered to deliver proteins of interest into the cytosol of specific mammalian cells.
Sandy Richter, Gudula Schmidt
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Saponin Fraction CIL1 from Lysimachia ciliata L. Enhances the Effect of a Targeted Toxin on Cancer Cells [PDF]
Pharmaceutics, 2023 Saponins are plant metabolites that possess multidirectional biological activities, among these is antitumor potential. The mechanisms of anticancer activity of saponins are very complex and depend on various factors, including the chemical structure of ...
Paulina Koczurkiewicz-Adamczyk +11 more
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The Road to Toxin-Targeted Therapeutic Antibodies [PDF]
mBio, 2014 Once an infection by a toxin-producing bacterium is well established, therapies such as antibiotics that target bacterial growth may have little impact on the ultimate patient outcome.
Thomas R. Kozel
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Targeted Toxins in Brain Tumor Therapy [PDF]
Toxins, 2010 Targeted toxins, also known as immunotoxins or cytotoxins, are recombinant molecules that specifically bind to cell surface receptors that are overexpressed in cancer and the toxin component kills the cell.
Walter A. Hall, Yan Michael Li
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Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms
Cell Reports, 2022 Summary: Targeted delivery of therapeutic proteins toward specific cells and across cell membranes remains major challenges. Here, we develop protein-based delivery systems utilizing detoxified single-chain bacterial toxins such as diphtheria toxin (DT ...
Songhai Tian +5 more
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Targeted Diphtheria Toxin-Based Therapy: A Review Article
Frontiers in Microbiology, 2019 Cancer remains one of the leading causes of death worldwide. Conventional therapeutic strategies usually offer limited specificity, resulting in severe side effects and toxicity to normal tissues.
Fatemeh Shafiee +2 more
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Targeting Toxins toward Tumors [PDF]
Molecules, 2021 Many cancer diseases, e.g., prostate cancer and lung cancer, develop very slowly. Common chemotherapeutics like vincristine, vinblastine and taxol target cancer cells in their proliferating states. In slowly developing cancer diseases only a minor part of the malignant cells will be in a proliferative state, and consequently these drugs will exert a ...
Henrik Franzyk +1 more
openaire +4 more sources
Frontiers in Immunology, 2023 BackgroundImmune-checkpoint inhibitors (ICIs) represent a revolution in cancer therapy and are currently implemented as standard therapy within several cancer indications.
Ane Sager Longva +2 more
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Current Research in Insect Science, 2022 The increasing global burden of mosquito-borne diseases require targeted, environmentally friendly, and sustainable approaches for effective vector control without endangering the non-target beneficial insect population.
Mahima Sharma, Vinay Kumar
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