Results 41 to 50 of about 248,862 (294)
Gene Therapy and Targeted Toxins for Glioma [PDF]
Current Gene Therapy, 2011 The most common primary brain tumor in adults is glioblastoma. These tumors are highly invasive and aggressive with a mean survival time of 15-18 months from diagnosis to death. Current treatment modalities are unable to significantly prolong survival in patients diagnosed with glioblastoma.
Maria G, Castro +12 more
openaire +2 more sources
Bispecific human IL2‐CCR4 immunotoxin targets human cutaneous T‐cell lymphoma
Molecular Oncology, 2020 The majority of clinically diagnosed cutaneous T‐cell lymphomas (CTCL) highly express the cell‐surface markers CC chemokine receptor 4 (CCR4) and/or CD25.
Haoyu Wang +9 more
doaj +1 more source
The Molecular Perspective: Targeted Toxins [PDF]
The Oncologist, 2001 are designed, using recombinant DNA technology and imagination, to seek out cancer cells and kill them. Two components are needed: a molecular machine to find cancer cells, and another molecular machine to do the killing. Fortunately, evolution has done much of the work for us.
openaire +3 more sources
Targeted Toxins for the Treatment of Prostate Cancer [PDF]
Biomedicines, 2021 Prostate cancer is the second most common cancer and the fifth leading cause of cancer deaths worldwide. Despite improvements in diagnosis and treatment, new treatment options are urgently needed for advanced stages of the disease. Targeted toxins are chemical conjugates or fully recombinant proteins consisting of a binding domain directed against a ...
openaire +4 more sources
The proteasome cap RPT5/Rpt5p subunit prevents aggregation of unfolded ricin A chain [PDF]
, 2013 The plant cytotoxin ricin enters mammalian cells by receptor-mediated endocytosis, undergoing retrograde transport to the endoplasmic reticulum (ER) where its catalytic A chain (RTA) is reductively separated from the holotoxin to enter the cytosol and ...
Afshar +61 more
core +2 more sources
The Cell-Cycle Regulatory Protein p21CIP1/WAF1 Is Required for Cytolethal Distending Toxin (Cdt)-Induced Apoptosis. [PDF]
, 2020 The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) induces lymphocytes to undergo cell-cycle arrest and apoptosis; toxicity is dependent upon the active Cdt subunit, CdtB.
Boesze-Battaglia, Kathleen +4 more
core +2 more sources
Gene Therapy and Targeted Toxins for Glioma [PDF]
Current Gene Therapy, 2005 The most common primary brain tumor in adults is glioblastoma. These tumors are highly invasive and aggressive with a mean survival time of nine to twelve months from diagnosis to death. Current treatment modalities are unable to significantly prolong survival in patients diagnosed with glioblastoma.
Gwendalyn D, King +5 more
openaire +2 more sources
The role of mycotoxins in the human exposome: Application of mycotoxin biomarkers in exposome-health studies [PDF]
, 2018 Mycotoxins are secondary metabolites produced by fungi that may contaminate different foods intended for human consumption, resulting in a widespread exposure worldwide. The novel exposome paradigm has the ambition to decipher the different environmental
Cano Sancho, German +3 more
core +4 more sources
Status and potential of bacterial genomics for public health practice : a scoping review [PDF]
, 2019 Background: Next-generation sequencing (NGS) is increasingly being translated into routine public health practice, affecting the surveillance and control of many pathogens.
Boon, Nele AM +6 more
core +2 more sources
Biomedicines, 2021 Triterpenoid saponins augment the cytotoxicity of saporin based immunotoxins. It is postulated that this results from a saponin-mediated increase in the endolysosomal escape of the toxin to the cytosol, but this remains to be confirmed.
Harrison J. Wensley +4 more
doaj +1 more source