Results 61 to 70 of about 248,862 (294)
The Glucocorticoid Receptor: A Revisited Target for Toxins [PDF]
Toxins, 2010 The hypothalamic-pituitary-adrenal (HPA) axis activation and glucocorticoid responses are critical for survival from a number of bacterial, viral and toxic insults, demonstrated by the fact that removal of the HPA axis or GR blockade enhances mortality rates.
Jeanette I. Webster Marketon +1 more
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski +9 more
wiley +1 more source
Whole-genome sequencing for national surveillance of Shiga toxin–producing Escherichia coli O157 [PDF]
, 2015 Background. National surveillance of gastrointestinal pathogens, such as Shiga toxin–producing Escherichia coli O157 (STEC O157), is key to rapidly identifying linked cases in the distributed food network to facilitate public health interventions.
Adak, Goutam +14 more
core +1 more source
Molecular Plant-Microbe Interactions, 2000 The Japanese pear pathotype of Alternaria alternata produces host-specific AK-toxin and causes black spot of Japanese pear. Previously, a cosmid clone, pcAKT-1, was isolated that contains two genes, AKT1 and AKT2, within a 5.0-kb region required for AK ...
Aiko Tanaka, Takashi Tsuge
doaj +1 more source
Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma
Pediatric Blood &Cancer, EarlyView.ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul +13 more
wiley +1 more source
Toxin-Based Targeted Therapy for Malignant Brain Tumors
Clinical and Developmental Immunology, 2012 Despite advances in conventional treatment modalities for malignant brain tumors—surgery, radiotherapy, and chemotherapy—the prognosis for patients with high-grade astrocytic tumor remains dismal. The highly heterogeneous and diffuse nature of astrocytic
Vidyalakshmi Chandramohan +3 more
doaj +1 more source
Toxins, 2020 The epidermal growth factor receptor (EGFR) was found to be a valuable target on prostate cancer (PCa) cells. However, EGFR inhibitors mostly failed in clinical studies with patients suffering from PCa.
Alexandra Fischer +4 more
doaj +1 more source
Non‐targeted Effects of a Targeted Toxin
The FASEB Journal, 2015 Saporin (SAP) alone or conjugated either with stabilized substance P (SSP‐SAP) or with an antibody to dopamine β‐hydroxylase (anti‐DBH‐SAP) leads to attenuation of arterial baroreflexes when injected bilaterally into the nucleus tractus solitarii (NTS) of rats.
William Talman +2 more
openaire +1 more source
Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle +5 more
wiley +1 more source
Metabolism of HT-2 Toxin and T-2 Toxin in Oats
Toxins, 2016 The Fusarium mycotoxins HT-2 toxin (HT2) and T-2 toxin (T2) are frequent contaminants in oats. These toxins, but also their plant metabolites, may contribute to toxicological effects. This work describes the use of 13C-assisted liquid chromatography–high-
Jacqueline Meng-Reiterer +5 more
doaj +1 more source