Results 131 to 140 of about 42,261,326 (330)
Environmental Research LettersSub-Saharan Africa is projected to be exposed to substantial climate change hazards, especially in its agricultural sector, so adaptation will be necessary to safeguard crop yields.
Lennart Jansen +2 more
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Soft systems methodology analysis for scoping in environmental impact statement in Israel [PDF]
, 1999 The current working paper will focus on Soft System Methodology (SSM) analysis of the process of issuing guidelines for Environmental Impact Statements (EIS) to developers in the Israeli context.
Haklay, M
core
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
A Multiple Regression Analysis of Personality’s Impact on Actuarial Exam Performance [PDF]
, 2011 Existing literature indicates that there is some connection between personality and both academic and work-related performance. The author\u27s intent for the research described herein is to explore this connection for students majoring in actuarial ...
Ciaffone, Matthew
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Impact Analysis of Multispecies Marine Resource Management [PDF]
In an attempt to study the regional income and employment impact of different harvesting regimes and harvesting patterns of marine resources, this article demonstrates an approach of combining multispecies bioeconomic modeling and input-output (1-0 ...
Heen, Knut
core +1 more source
Analysis of the Impact and Value of Community Benefit Clauses in Procurement [PDF]
, 2015 This research draws on data from a large scale e-survey of public organisations and in-depth analysis of 24 individual ...
Glass, Andrea +3 more
core