Results 91 to 100 of about 499,828 (261)

Structural Performance of Ferrocement Panels under Low- and High-Velocity Impact Load. [PDF]

ACS Omega, 2023
Sathe S, Kangda MZ, Khan MA, Alharbi YR, Qamar O.   +4 more
europepmc   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Experimental analysis on impact load of flash flood against a passable structure. [PDF]

PLoS One, 2023
Wang S, Zheng H, Huang E, Liu X, Luo M.
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Evaluation of the effect of wheel tread condition on the dynamic response of PC sleepers

Nihon Kikai Gakkai ronbunshu
Prestressed concrete sleepers (PC sleepers) are an important component of railway tracks. The dynamic response of PC sleepers to passing trains is influenced by various factors relating to the vehicles and tracks. However, few studies have quantitatively
Keiichi GOTO, Tsutomu WATANABE, Tsugutoshi KAWAGUCHI, Takeshi SUEKI, Tomoya YAMASHITA, Daisuke MIMURA   +5 more
doaj   +1 more source

An analysis of impact load and fragmentation dimension to explore energy dissipation patterns in coal crushing. [PDF]

Sci Rep, 2023
Wang XH, Jing W, Zhang WB, Wang JH, Yun QL, Wang YQ, Yi S.   +6 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Experimental and Numerical Analysis of a Car Body Shield Loaded with a Ballistic Impact

Machines
This paper presents the possibility of using additional ballistic shields based on composite materials, which are applied to the body of a passenger car. A ballistic laminate made of Twaron T 750 aramid fabric with 5 mm thick and 2 mm thick magnetic foil
Maciej Mamys, Dariusz Pyka, Adam Kurzawa, Mirosław Baocian, Narcis Barsan, Krzysztof Jamroziak   +5 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Study on Damage Characteristics and Failure Modes of Gypsum Rock under Dynamic Impact Load. [PDF]

Materials (Basel), 2023
Ge Y, Ren G, Zhang C, Shi Y, Zhang L.
europepmc   +1 more source